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Matt Walker: Sleep | Lex Fridman Podcast #210


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The following is a conversation with Matt Walker,
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sleep scientist, professor of neuroscience
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and psychology at Berkeley, author of Why We Sleep
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and The Host of a new podcast
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called The Matt Walker Podcast.
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It's 10 minute episodes a couple of times a month
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covering sleep and other health and science topics.
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I love it and recommend it highly.
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It's up there with the greats
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like the Huberman Lab podcast with Andrew Huberman.
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And I think Davis and Claire is putting out
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an audio series soon too.
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I can't wait to listen to it.
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I'm really excited by the future of science
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in the podcasting world.
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To support this podcast, please check out our sponsors,
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Stamps.com, Squarespace, Athletic Greens,
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BetterHelp and On It.
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There are links are in the description.
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As a side note, let me say that to me,
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a healthy life is one in which you fall in love
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with the world around you, with ideas, with people,
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with small goals and big goals, no matter how difficult,
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with dreams you hold onto and chase for years.
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Life should be lived fully.
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That to me is the priority.
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That to me is a healthy life.
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Second to that is the understanding
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and the utilization of the best available science
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on diet, exercise, supplements, sleep
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and other lifestyle choices.
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To me, science in the realm of health is a guide
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for we should try not the absolute truth
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of how to live life.
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The goal is to learn to listen to your body
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and figure out what works best for you.
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All that said, a good night's sleep can be a great tool
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in making life awesome and productive.
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And Matt is a great advocate of the how
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and the why of sleep.
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We agree on some things and disagree on others,
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but he's a great human being, a great scientist
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and is a recently a friend,
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with whom I enjoy having these wide ranging conversations.
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This is the Lex Friedman podcast
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and here is my conversation with Matt Walker.
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You should try these shades on and see what you look like.
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So they are now your shades and that's not the question.
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It's the same thing as Putin took the Super Bowl ring
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and it's now his ring.
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Yeah, one wonders if he was offered it, but they are yours.
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When did you first fall in love
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with the dream of understanding sleep?
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Like where did the fascination with sleep begin?
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So back in the United Kingdom,
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you can sort of start doing medicine at age to 18
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and it's a five year program.
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And I was at the Queen's Medical Center in the UK
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and I remember just being fascinated
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by states of consciousness and particularly anesthesia.
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I was thinking, isn't that within seconds
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I can take a perfectly conscious human being
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and I can remove all existence of the mentality
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and their awareness within seconds.
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And that stunned me.
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So I started to get really interested in conscious states.
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I even started to read a lot about hypnosis
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and all of these things, hypnosis,
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even sleep and dreams at the time,
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they were very esoteric.
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It was sort of charlatan science at that stage.
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And I think almost all of my colleagues
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and I are accidental sleep researchers.
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No one as I recall in the classroom
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when you're sort of five years old and the teacher says,
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what would you like to be when you grow up?
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No one's putting their hand up and saying,
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I would love to be a sleep researcher.
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And so when I was doing my PhD,
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I was trying to identify different forms of dementia
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very early on in the course.
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And I was using electrical brainwave recordings to do that.
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And I was failing miserably.
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It was a disaster, just no result after no result.
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And I used to go home to the doctor's residence
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with this sort of little igloo of journals
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that at the weekend I would sort of sit in
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and read and which I'm now thinking,
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do I really want to admit this?
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Because it sounds like I had no social life,
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which I didn't, I was social leper.
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But and I started to realize that some parts of the brain
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were sleep related areas.
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And some dementias were eating away
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those sleep related areas.
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Other dementias would leave them untouched.
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And I thought, well, I'm doing this all wrong.
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I'm measuring my patients while they're awake.
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Instead I should be measuring them
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while they're asleep.
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Started doing that, got some amazing results.
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And then I wanted to ask the question,
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is that sleep disruption
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that my patients are experiencing
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as they go into dementia?
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Maybe it's not a symptom of the dementia.
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I wonder if it's a cause of the dementia.
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And at that point, which was golf golf 20 years ago,
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no one could answer a very simple fundamental question.
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Why do we sleep?
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And I at the time didn't realize
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that some of the most brilliant minds
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in scientific history had tried to answer that question
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and failed.
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And at that point, I just thought, well,
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I'm going to go and do a couple of years of sleep research
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and I'll figure out why we sleep.
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And then I'll come back to my patients
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in this question of dementia.
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And as I said, that was 20 years ago.
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And what I realized is that hard questions
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care very little about who asks them.
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They will meter out their lessons of difficulty all the same.
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And I was schooled in the difficulty of the question,
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why do we sleep?
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But in truth, 20 years later,
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we've had to upend the question
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rather than saying, why do we sleep?
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And by the way, the answer then was
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that we sleep to cure sleepiness.
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Which is like saying, we eat to cure hunger.
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That tells you nothing about the physiological benefits
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of food, same with sleep.
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Now we've actually have to ask the question,
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is there any physiological system in the body
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or any major operation of the mind
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that isn't wonderfully enhanced when we get sleep
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or demonstrably impaired when we don't get enough?
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And so far, for the most part, the answer seems to be no.
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So far, the answer seems to be no.
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So why does the body and the mind crave sleep then?
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Why do we sleep?
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How can we begin to answer that question then?
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So I think one of the ways that I think about this all,
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one of the answers that came to me is the following.
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The reason that we implode so quickly
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and so thoroughly with insufficient sleep
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is because human beings seem to be one of the few species
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that will deliberately deprive themselves of sleep
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for no apparent good reason, biological.
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And what that led me then to was the following.
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Mother nature as a consequence.
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So no other species does what we do in that context.
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There are a few species that do undergo sleep deprivation,
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but for very obvious, clear biological reasons.
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One is when they're in a condition of severe starvation.
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The second is when they're caring for their newborn.
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So for example, killer whales will often deprive themselves.
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The female will go away from the pod, give birth,
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and then bring the calf back.
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And during that time,
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the mother will undergo sleep deprivation.
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And then the third one is during migration
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when birds are flying trans oceanographic to 3000 miles.
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But for the most part,
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it's never seen in the animal kingdom,
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which brings me back to the point.
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Therefore, mother nature in the course of evolution
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has never had to face the challenge
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of this thing called sleep deprivation.
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And therefore she has never created a safety net in place
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to circumnavigate this common influence.
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And there is a good example where we have,
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which is called the adipose cell, the fat cell.
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Because during our evolutionary past,
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we had famine and we had feast.
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And mother nature came up with a very clever recipe,
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which is how can I store caloric credit
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so that I can spend it when I go into debt?
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And the fat cell was born, brilliant idea.
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Where is the fat cell for sleep?
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Where is that sort of banking chip for sleep?
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And unfortunately, we don't seem to have one
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because she's never had to face that challenge.
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So even if there's not some kind of physics
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fundamental need for sleep
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that physiologically or psychologically,
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the fact is most organisms are built such that they need it.
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And then mother nature never built an extra mechanism
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for sleep deprivation.
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So it's interesting that why we sleep
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by not have a good answer,
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but we need to sleep to be healthy is nevertheless true.
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Yeah, and we have many answers right now.
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In some ways, the question of why we sleep
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was the wrong question too.
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It's what are the pluripotent many reasons we sleep?
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We don't just sleep for one reason
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because from an evolutionary perspective,
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it is the most idiotic thing that you could imagine.
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When you're sleeping, you're not finding a mate,
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you're not reproducing, you're not caring for your young,
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you're not foraging for food.
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And worse still, you're vulnerable to predation.
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So on any one of those grounds,
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especially as a collective,
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sleep should have been strongly selected
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against in the course of evolution.
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But in every species that we've studied carefully to date,
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sleep is present.
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So it is important.
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So like you're right.
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I think I've heard arguments from an evolutionary biology
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perspective that sleep is actually advantageous.
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Maybe like some kind of predator, prey relationships.
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But you're saying, and actually makes way more sense
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what you're saying is it should have been selected against.
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Like why close your eyes?
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Yeah, why?
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Because there was an energy conservation hypothesis for a while,
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which is that we need to essentially go into low battery mode,
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power down because it's unsustainable.
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But in fact, that actually has been blasted out the water
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because sleep is an incredibly active process.
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In fact, the difference between you just lying on the couch
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but remaining conscious versus you lying on the couch
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and falling asleep, it's only a savings of about 140,
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150 calories.
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In other words, you just go out and club another baby seal
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or whatever it was and you wouldn't worry.
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So it has to be much more to it than energy conservation,
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much more to it than sharing ecosystem space and time,
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much more to it than simply predator prey relationships.
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If sleep really did, and looking back,
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even very old evolutionary organisms
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like earthworms, millions of years old,
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they have periods where they're active
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and periods where they're passively asleep.
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It's called lethargicus.
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And so what that in some way suggested to me
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was sleep evolved with life itself on this planet.
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And then it has fought its way through heroically
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every step along the evolutionary pathway,
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which then leads to the sort of famous sleep statement
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from a researcher that if sleep doesn't serve
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an absolutely vital function or functions,
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then it's the biggest mistake the evolutionary process
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has ever made.
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And we've now realized Mother Nature
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didn't make a spectacular blender with sleep.
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You've mentioned an idea of conscious states.
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Do you think of sleep as a fundamentally different
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conscious state than awakeness?
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And how many conscious states are there
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sort of when you're into it, your understanding
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of what the mind can do?
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Do you think awake state, sleep state,
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or is there some kind of continuum?
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There's a complicated state transition diagram.
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Like how do you think about this whole space?
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I think about it as a state space diagram.
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And I think it's probably more of a continuum
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than we have believed it to be or suggested it to be.
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So we used to think absent of anesthesia
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that there were already three main states of consciousness
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that was being awake, being in non rapid eye movement sleep
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or non dream sleep, and then being in rapid eye movement
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sleep or dream sleep.
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And those were the three states within which your brain
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could percolate and be conscious.
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Conscious during non REM sleep is maybe a stretch to say,
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but I still believe there is plenty of consciousness there.
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I don't believe that though anymore.
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And the reason is because we can have daydreams
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and we are in a very different wakeful state
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in those daydreams than we are when we are, as we are now,
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together present and extraceptively focused
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rather than intraceptively focused.
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And then we also know that as you
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are sort of progressing into those different stages of sleep
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during non REM sleep, you can also still dream.
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It depends on your definition of dreaming,
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but we seem to have some degree of dreaming
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in almost all stages of sleep.
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We've also then found that when you are sleep deprived,
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there are even individual brain cells will fall asleep.
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Despite the animal being, you know,
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behaviorally from best we can tell awake,
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individual brain cells and clusters of brain cells
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will go into a sleep like state.
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And humans do this too, when we are sleep deprived,
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we have what are called microsleeps,
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where the eyelid will partially close
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and the brain essentially falls lapses
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into a state of sleep,
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but behaviorally you seem to be awake
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and the danger here is road traffic accidents.
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So these are what we call these sort of microsleep events
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at the wheel.
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Now, if you're traveling at 65 miles an hour
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in a two ton vehicle, you know,
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it takes probably around one second
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to drift from one lane to the next
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and it takes two seconds to go completely off the road.
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So if you have one of these microsleeps at the wheel,
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you know, it could be the last microsleep
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that you ever have, but I don't now see it as a set of,
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you know, very binary distinct, you know,
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step function states, it's not a one or a zero.
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I see it more of a, as a continuum.
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Yeah.
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So I've for five, six years at MIT
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really focused on this human side of driving question.
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And one of the big concerns is the microsleeps,
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drowsiness, these kinds of ideas.
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And one of the open questions was,
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is it possible through computer vision to detect
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or any kind of sensors?
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The nice thing about computer vision
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is you don't have to have direct contact to the person.
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Is it possible to detect increases in drowsiness?
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Is it possible to detect these kinds of microsleeps
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or actually just sleep in general?
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Among other things, like distraction,
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these are all words that have so many meanings
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and so many debates, like attention is a whole nother one,
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just because you're looking at something
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doesn't mean you're loading in the information.
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Just because you're looking away
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doesn't mean your peripheral vision can't pick up
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the important information.
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There's so many complicated vision science things there.
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So I wonder if you could say something to,
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they say the eyes are the windows to the soul.
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Do you think the eyes can reveal something
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about sleepiness through computer vision,
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through just looking at the video of the face.
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And Andrew Huberman and I, your friend,
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have talked about this.
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00:16:31.080
So we'd love to work on this together.
link |
00:16:33.520
You should do.
link |
00:16:34.360
It's a fascinating problem,
link |
00:16:35.640
but drowsiness is a tricky one.
link |
00:16:37.200
So there's what kind of information?
link |
00:16:39.320
There's blinking and there's eye movement.
link |
00:16:42.680
And those are the ones that can be picked up
link |
00:16:46.000
with computer vision.
link |
00:16:46.880
Do you think those are signals that can be used
link |
00:16:48.960
to say something about where we are in this continuum?
link |
00:16:52.680
Yeah, I do.
link |
00:16:53.520
And I think there are a number of other features too.
link |
00:16:55.600
I think aperture of eye,
link |
00:16:59.480
so in other words, partial closures, full closures,
link |
00:17:03.120
duration of those closures,
link |
00:17:04.760
duration of those partial closures of the eyelid.
link |
00:17:09.360
I think there may be some information in the pupil as well,
link |
00:17:13.360
because as we're transitioning between those states,
link |
00:17:16.400
there are changes in what's called
link |
00:17:17.920
the automatic nervous system,
link |
00:17:19.280
or technically it's called the autonomic nervous system,
link |
00:17:22.800
part of which will control your pupillary size.
link |
00:17:27.080
So I actually think that there is probably
link |
00:17:29.880
a wealth of information.
link |
00:17:32.320
When you combine that,
link |
00:17:33.600
probably with aspects of steering angle, steering maneuver.
link |
00:17:39.920
And if you can sense the pressure on the pedals as well,
link |
00:17:44.520
my guess is that there is some combinatorial feature
link |
00:17:48.080
that creates a phenotype of you are starting to fall asleep
link |
00:17:53.080
and as the autonomous controls develop,
link |
00:17:58.080
it's time for them to kick in.
link |
00:18:00.480
Some manufacturers, auto manufacturers,
link |
00:18:02.800
sort of have something beta version,
link |
00:18:05.680
or maybe an alpha version of this,
link |
00:18:07.920
already starting to come online
link |
00:18:09.440
where they have a little camera in the wheel
link |
00:18:11.960
that I think tries to look at some features.
link |
00:18:14.560
Almost everybody doing this and it's very alpha.
link |
00:18:17.760
So the thing that you currently have
link |
00:18:23.200
and some people have that in their car,
link |
00:18:24.400
there's a coffee cup or something that comes up
link |
00:18:26.480
that you might be sleepy.
link |
00:18:28.000
The primary signal that they're comfortable using
link |
00:18:31.560
is steering wheel reversals.
link |
00:18:33.400
So basically using your interaction with the steering wheel
link |
00:18:37.440
and how much you're interacting with it
link |
00:18:39.720
as a sign of sleepiness.
link |
00:18:40.920
So if you have to constantly correct the car,
link |
00:18:43.600
that's a sign of you starting to drift into microsleep.
link |
00:18:47.360
I think that's a very, very crude signal.
link |
00:18:49.520
It's probably a powerful one.
link |
00:18:51.160
There's a whole nother component to this,
link |
00:18:52.760
which is it seems like it's so driver and subject dependent.
link |
00:18:59.240
How our behavior changes as we get sleepy and drowsy
link |
00:19:04.240
seems to be different in complicated, fascinating ways
link |
00:19:08.160
where you can't just use one signal.
link |
00:19:09.800
It's kind of like what you're saying.
link |
00:19:11.120
There has to be a lot of different signals
link |
00:19:13.560
that you should then be able to combine.
link |
00:19:15.400
The hope is the search is for universal signals
link |
00:19:19.760
that are pretty damn good for 90% of people.
link |
00:19:23.560
But I don't think we need to take necessarily
link |
00:19:26.240
quite that approach.
link |
00:19:27.240
I think what we could do in some clever fashion
link |
00:19:31.120
is using the individual.
link |
00:19:33.520
So what you and I are perhaps suggesting here
link |
00:19:35.640
is that there is an array of features that we know
link |
00:19:39.440
provide information that is sensitive
link |
00:19:42.080
to whether or not you're falling asleep at the wheel.
link |
00:19:44.560
Some of those, let's say that there are 10 of them.
link |
00:19:47.920
For me, seven of them are the cardinal features.
link |
00:19:51.840
For you, however, six of them,
link |
00:19:54.560
and they're not all the same sort of overlapping,
link |
00:19:58.080
are those for you.
link |
00:19:59.960
I think what we need is algorithms
link |
00:20:01.880
that can firstly understand when you are well slept.
link |
00:20:04.480
So let's say that people have sleep trackers at night
link |
00:20:06.960
and then your car integrates that information.
link |
00:20:09.240
And it understands when you are well slept.
link |
00:20:12.640
And then you've got the data of the individual behavior
link |
00:20:16.640
unique to that individual snowflake like
link |
00:20:20.320
when they are well slept.
link |
00:20:21.880
This is the signature of well rested driving.
link |
00:20:26.520
Then you can look at deviations from that
link |
00:20:29.200
and pattern match it with the sleep history
link |
00:20:32.200
of that individual.
link |
00:20:33.680
And then I don't need to find the sort of,
link |
00:20:37.440
the one size fits all approach for 99% of the people.
link |
00:20:41.040
I can create a very bespoke, tailor like set of features
link |
00:20:45.400
of a Savile Row suit of sleepiness features.
link |
00:20:49.760
That would be my,
link |
00:20:50.600
if you want to ask me about moonshots and crazy ideas,
link |
00:20:53.520
that's where I go.
link |
00:20:54.360
But to start with, I think your approach is a great one.
link |
00:20:58.160
Let's find something that covers 99% of the people.
link |
00:21:02.080
Because the worrying thing about microsleeps, of course,
link |
00:21:04.720
unlike drugs or alcohol,
link |
00:21:07.400
which certainly is a terrible thing
link |
00:21:10.320
to be behind the wheel.
link |
00:21:11.920
With those, often you react too late.
link |
00:21:17.640
And that's the reason you get into an accident.
link |
00:21:20.160
When you fall asleep behind the wheel,
link |
00:21:22.800
you don't react at all.
link |
00:21:25.440
At that point, there is a two ton missile
link |
00:21:27.640
driving down the street and no one's in control.
link |
00:21:29.920
That's why those accidents can often be more dangerous.
link |
00:21:34.400
Yeah, and the fascinating thing is,
link |
00:21:37.320
in the case of semi autonomous vehicles
link |
00:21:39.400
like Tesla autopilot,
link |
00:21:40.920
this is where I've had disagreements with Mr. Elon Musk.
link |
00:21:46.960
And the human factors community,
link |
00:21:50.000
which is this community that one of the big things they study
link |
00:21:53.680
is human supervision over automation.
link |
00:21:56.760
So you have like pilots supervising an airplane
link |
00:22:00.640
that's mostly flying autonomously.
link |
00:22:02.720
The question is, when we're actually doing the driving,
link |
00:22:06.720
how do microsleeps are general?
link |
00:22:09.880
How does drowsiness progress?
link |
00:22:12.120
And how does it affect our driving?
link |
00:22:14.040
That question becomes more fascinating,
link |
00:22:15.920
more complicated when your task is not driving,
link |
00:22:19.560
but supervising the driving.
link |
00:22:21.640
So your task is to take over when stuff goes wrong.
link |
00:22:24.800
And that is complicated,
link |
00:22:27.160
but the basic conclusions from many decades
link |
00:22:30.280
is that humans are really crappy at supervising
link |
00:22:34.320
because they get drowsy and lose vigilance much, much faster.
link |
00:22:39.560
The really surprising thing with Tesla autopilot,
link |
00:22:42.280
it was surprising to me,
link |
00:22:44.520
surprising to the human factors community,
link |
00:22:47.040
and in fact, they still argue with me about it,
link |
00:22:49.360
is it seems that humans in Teslas with autopilot
link |
00:22:55.280
and other similar systems are not becoming less vigilant,
link |
00:22:58.800
at least with the studies we've done.
link |
00:23:01.640
So there's something about the urgency of driving.
link |
00:23:05.360
I can't, I'm not sure the why,
link |
00:23:07.240
but there's something about the risk.
link |
00:23:08.920
I think the fact that you might die
link |
00:23:11.880
is still keeping people awake.
link |
00:23:14.480
The question is, as Tesla autopilot
link |
00:23:16.560
or similar systems get better and better and better,
link |
00:23:19.440
how does that affect increasing drowsiness?
link |
00:23:21.720
And that's when you need to have,
link |
00:23:23.280
that's where the big disagreement was,
link |
00:23:25.400
you need to have driver sensing,
link |
00:23:27.360
meaning driver facing camera that tracks
link |
00:23:32.040
some kind of information about the face
link |
00:23:33.720
that can tell you drowsiness.
link |
00:23:36.120
So you can tell the car if you're drowsy
link |
00:23:39.040
so that the car can be like,
link |
00:23:40.280
you should be probably driving or pull to the side.
link |
00:23:43.960
Right, or I need to do some of the heavy lifting here.
link |
00:23:47.480
Yeah, so there needs to be that dance
link |
00:23:49.560
of interaction of human and machine,
link |
00:23:53.720
but currently it's mostly steering wheel based.
link |
00:23:56.880
So, this idea that your hands should be on the steering wheel,
link |
00:24:02.400
that's a sign that you're paying attention
link |
00:24:05.840
is an outdated and a very crude metric.
link |
00:24:09.440
I agree, yeah.
link |
00:24:11.240
I think there are far more sophisticated ways
link |
00:24:13.360
that we can solve that problem if we invest.
link |
00:24:17.200
Can I ask you a big philosophical question
link |
00:24:20.600
before we get into fun details?
link |
00:24:23.000
On the topic of conscious states,
link |
00:24:28.400
how fundamental do you think is consciousness
link |
00:24:31.240
to the human mind?
link |
00:24:33.400
I ask this from almost like a robotics perspective.
link |
00:24:36.440
So in your study of sleep,
link |
00:24:39.080
do you think the hard question of consciousness,
link |
00:24:42.120
that it feels like something to be us,
link |
00:24:45.400
is that like a nice little feature,
link |
00:24:46.920
like a quirk of our mind,
link |
00:24:50.280
or is it some how fundamental?
link |
00:24:52.040
Because sleep feels like we take a step out
link |
00:24:55.840
of that consciousness a little bit.
link |
00:24:57.800
So from all your study of sleep,
link |
00:25:00.600
do you think consciousness is deeply part of who we are,
link |
00:25:04.320
or is it just a nice trick?
link |
00:25:06.960
I think it's a deeply embedded feature
link |
00:25:09.680
that I can imagine has a whole panoply of biological benefits.
link |
00:25:16.120
But to your point about sleep,
link |
00:25:17.760
what is interesting if you do a lot of dream research
link |
00:25:20.960
and we've done some, it's very, very rare at all,
link |
00:25:27.280
in fact, for you to end up becoming someone
link |
00:25:31.200
other than who you are in your dreams.
link |
00:25:33.440
Now, you can have third person perspective dreams
link |
00:25:35.960
where you can see yourself in the dream
link |
00:25:38.760
as if you've risen above your physical being.
link |
00:25:45.000
But for the most part, it's very rare
link |
00:25:47.280
that we lose our sense of conscious self.
link |
00:25:51.400
And maybe I'm sort of doing a sleight of hand
link |
00:25:53.720
because it's really what I'm saying is it's very rare
link |
00:25:55.600
that we lose our sense of who we are in dreams.
link |
00:25:58.720
We never do.
link |
00:25:59.960
Now, that's not to suggest that dreams aren't utterly bizarre.
link |
00:26:04.400
And I mean, when you slept last night,
link |
00:26:07.800
which I know may have been perhaps a little less than me,
link |
00:26:12.080
but when you went into dreaming,
link |
00:26:14.760
you became flagrantly psychotic
link |
00:26:18.240
and there are five essentially good reasons.
link |
00:26:20.480
Firstly, you started to see things which were not there.
link |
00:26:23.520
So you were hallucinating.
link |
00:26:25.240
Second, you believe things that couldn't possibly be true.
link |
00:26:28.320
So you were delusional.
link |
00:26:30.200
Third, you became confused about time and place and person.
link |
00:26:35.320
So you're suffering from what we would call disorientation.
link |
00:26:38.600
Fourth, you have wildly fluctuating emotions,
link |
00:26:41.680
something that psychiatrists will call being affectively labile.
link |
00:26:46.480
And then how wonderful you woke up this morning
link |
00:26:48.560
and you forgot most if not all of that dream experience.
link |
00:26:51.120
So you're suffering from amnesia.
link |
00:26:52.840
If you had to experience any one of those five things
link |
00:26:55.920
while you were awake,
link |
00:26:57.000
you would probably be seeking psychological help.
link |
00:27:00.600
But so I placed that as a backdrop
link |
00:27:03.920
against your astute question
link |
00:27:06.160
because despite all of that psychosis,
link |
00:27:11.080
there is still a present self nested at the heart of it,
link |
00:27:16.200
meaning that I think it's very difficult for us
link |
00:27:19.800
to abandon our conscious sense of self.
link |
00:27:24.160
And if it's that hard,
link |
00:27:25.920
the old adage in some ways
link |
00:27:27.200
that you can't outrun your shadow,
link |
00:27:29.280
but here it's more of a philosophical question
link |
00:27:31.440
which is about the conscious mind
link |
00:27:33.680
and what the state of consciousness actually means
link |
00:27:36.240
in a human being.
link |
00:27:38.120
So I think that that to me, you become so dislocated
link |
00:27:43.720
from so many other rational ways of waking consciousness.
link |
00:27:47.880
But one thing that won't go away,
link |
00:27:49.560
that won't get perturbed or sort of, you know,
link |
00:27:54.680
manacled, is this your sense of conscious self?
link |
00:27:58.200
Yeah, that's a strong sign that consciousness
link |
00:28:00.160
is fundamental to the human mind.
link |
00:28:03.400
Or we're just creatures of habit
link |
00:28:04.920
who got used to having consciousness.
link |
00:28:06.880
Maybe it just takes a lot of either chemical substances
link |
00:28:11.120
or a lot of like mental work to escape that.
link |
00:28:16.000
I mean, it's like trying to launch a rocket.
link |
00:28:19.360
You know, the energy that has to be put in
link |
00:28:22.120
to create escape velocity
link |
00:28:24.640
from the gravitational pull of this thing
link |
00:28:26.680
called planet Earth is immense.
link |
00:28:29.120
Well, the same thing is true
link |
00:28:31.160
for us to abandon our sense of conscious self.
link |
00:28:36.160
Self, the amount of biological amount of substances,
link |
00:28:39.400
the amount of wacky stuff that you have to do
link |
00:28:42.080
to truly get escape velocity from your conscious self.
link |
00:28:46.440
What does that tell us about then
link |
00:28:48.440
the fundamental state of our conscious self?
link |
00:28:52.280
Yeah, it also probably says that it's quite useful
link |
00:28:55.600
to have consciousness for survival
link |
00:28:58.720
and for just operation in this world.
link |
00:29:01.480
And perhaps for intelligence.
link |
00:29:02.840
I'm one of the, on the AI side,
link |
00:29:05.040
people that think that intelligence requires consciousness.
link |
00:29:10.320
So like high levels of general intelligence
link |
00:29:13.000
requires consciousness.
link |
00:29:14.480
Most people in the AI field think like consciousness
link |
00:29:17.760
and intelligence are fundamentally different.
link |
00:29:19.640
You could build a computer that's super intelligent.
link |
00:29:22.160
It doesn't have to be conscious.
link |
00:29:23.880
I think that if you define super intelligence
link |
00:29:26.680
by being good at chess, yes.
link |
00:29:28.640
But if you define super intelligence
link |
00:29:30.880
as being able to operate in this living world
link |
00:29:33.840
of humans and be able to perform
link |
00:29:36.320
all kinds of different tasks, consciousness,
link |
00:29:39.240
it seems to be some all fundamental
link |
00:29:41.800
to richly integrate yourself into the human experience
link |
00:29:46.840
into society.
link |
00:29:48.360
It feels like you have to be a conscious being.
link |
00:29:51.000
But then we don't even know what consciousness is.
link |
00:29:53.480
And we certainly don't know how to engineer it
link |
00:29:55.680
in our machines.
link |
00:29:56.720
I love the fact that there are still questions
link |
00:30:00.160
that are so embryonic
link |
00:30:02.120
because I suspect it's the same with you.
link |
00:30:05.640
Answers to me are simply ways to get to more questions.
link |
00:30:10.040
It's questions where, questions turn me on, answers less so.
link |
00:30:15.040
And I love the fact that we are still embryonic
link |
00:30:18.880
in our sense of arguing about
link |
00:30:20.960
even what the definition of consciousness is.
link |
00:30:23.840
But I also find it fascinating.
link |
00:30:26.400
I think it's thoroughly delightful
link |
00:30:27.720
to absorb yourself in the thought.
link |
00:30:30.160
Think about the brain and we can move back
link |
00:30:33.800
across the complexity of phylogeny
link |
00:30:35.960
from humans to mammals to birds to reptiles, amphibians, fish.
link |
00:30:42.000
You can bacteria, whatever you want.
link |
00:30:44.920
And you can go through this and say,
link |
00:30:46.080
okay, where is the hard line
link |
00:30:47.960
of what we would define as consciousness?
link |
00:30:51.240
And I'm sure it's got something to do
link |
00:30:52.800
with the complexity of the neural system.
link |
00:30:55.320
Of that, I'm fairly certain.
link |
00:30:57.560
But to me, it's always been fascinating.
link |
00:31:01.360
So what is it then?
link |
00:31:02.640
Is it that I just keep adding neurons to a Petri dish
link |
00:31:06.080
and I just keep adding them and adding them and adding them.
link |
00:31:08.200
At some point when I hit a critical mass
link |
00:31:10.240
of interconnected neurons,
link |
00:31:11.840
that is the mass of the interconnected human brain,
link |
00:31:15.160
then bingo.
link |
00:31:17.600
All of a sudden it kicks into gear
link |
00:31:19.760
and we have consciousness.
link |
00:31:21.320
Like a phase shift, phase transition of some kind.
link |
00:31:23.560
Correct, yeah.
link |
00:31:24.480
But there is something about the complexity
link |
00:31:26.240
of the nervous system that I think is fundamental
link |
00:31:28.640
to consciousness and the reason I bring that up
link |
00:31:30.320
is because when we're trying to then think
link |
00:31:32.480
about creating it in an artificial way,
link |
00:31:35.200
does that inform us as to the complexity
link |
00:31:37.680
that we should be looking at in terms of development?
link |
00:31:41.240
I also think that it's a missed opportunity
link |
00:31:44.400
in the sort of digital space
link |
00:31:48.240
for us to try to recreate human consciousness.
link |
00:31:52.200
We've already got human consciousness.
link |
00:31:54.640
What if we were to think about
link |
00:31:56.480
creating some other form of,
link |
00:31:58.720
why do we have to think that the ultimate
link |
00:32:01.560
in the creation of an artificial intelligence
link |
00:32:05.680
is the replication of a human state of consciousness?
link |
00:32:11.840
Can we not think outside of our own consciousness
link |
00:32:16.600
and believe that there is something even more incredible
link |
00:32:19.280
or more complimentary, more orthogonal?
link |
00:32:22.320
Mm hmm.
link |
00:32:24.200
So I'm sometimes perplexed
link |
00:32:26.880
that people are trying to mimic human consciousness
link |
00:32:30.560
rather than think about creating something that's different.
link |
00:32:34.520
So yeah, I think of human consciousness
link |
00:32:36.600
or consciousness in general as this magic
link |
00:32:41.000
superpower that allows us to deeply experience the world.
link |
00:32:44.760
And just as you're saying,
link |
00:32:45.840
I don't think that superpower has to take
link |
00:32:47.720
the exact flavor as humans have.
link |
00:32:49.800
That's my love for robots.
link |
00:32:51.880
I would love to add the ability to robots
link |
00:32:56.200
that can experience the world and other humans deeply.
link |
00:33:01.760
I'm humbled by the fact that that idea
link |
00:33:04.040
does not necessarily need to look anything like
link |
00:33:06.960
how humans experience the world.
link |
00:33:09.320
But there's a dance of human to robot connection,
link |
00:33:14.800
the same way human to dog or human to cat connection.
link |
00:33:18.520
There's a magic there to that interaction.
link |
00:33:21.880
And I'm not sure how to create that magic,
link |
00:33:23.600
but it's a worthy effort.
link |
00:33:25.120
I also love just exactly as you said,
link |
00:33:27.960
on the question of consciousness
link |
00:33:29.440
or engineering consciousness,
link |
00:33:32.080
the fun thing about this problem
link |
00:33:34.920
is it seems obvious to me that 100 years from now,
link |
00:33:38.800
no matter what we do today,
link |
00:33:41.280
people who are still here will laugh
link |
00:33:44.920
at how silly our notions were.
link |
00:33:47.280
So it's almost impossible for me to imagine
link |
00:33:49.880
that we will truly solve this problem fully in my lifetime.
link |
00:33:56.320
And more than that, everything we'll do
link |
00:34:00.080
will be silly 100 years from now.
link |
00:34:02.600
But that makes it fun to me
link |
00:34:05.600
because it's like you have the full freedom
link |
00:34:07.920
to not even be right, just to try, just to try as freedom.
link |
00:34:12.920
And that's how I see it. Get me that T shirt, please.
link |
00:34:17.560
I love that.
link |
00:34:18.480
So, and, you know, human robot interaction is fascinating
link |
00:34:21.880
because it's like watching dancing.
link |
00:34:24.040
I've been dancing tango recently.
link |
00:34:28.160
And just, it's like, there is no goal.
link |
00:34:30.920
The goal is to create something magical.
link |
00:34:33.640
And whether consciousness or emotion
link |
00:34:37.440
or elegance of movement, all of those things
link |
00:34:40.160
aid in the creation of the magic.
link |
00:34:43.400
And it's a free, it's an art form to explore
link |
00:34:46.080
how to make that, how to create that
link |
00:34:49.920
in a way that's compelling.
link |
00:34:51.280
Yeah, I love the line in Sense of a Woman with Al Pacino
link |
00:34:54.440
where he's speaking about the tango
link |
00:34:56.000
and he said, really, it's just freedom
link |
00:34:57.720
that if you get tangled up, you just keep tangoing on.
link |
00:35:01.880
I still to this day, I think first or second time
link |
00:35:06.400
I talked to Joe Rogan on his podcast,
link |
00:35:08.880
I said, we got into this heated argument
link |
00:35:11.520
about whether Sense of a Woman is a better movie
link |
00:35:14.640
than John Wick.
link |
00:35:16.800
Because it's one of my favorite movies for many reasons.
link |
00:35:20.320
One is Sense of a Woman.
link |
00:35:21.960
Sense of a Woman.
link |
00:35:23.840
Partially.
link |
00:35:24.680
I didn't know that, by the way.
link |
00:35:25.520
It was just, you just,
link |
00:35:26.800
Yeah, I didn't know if you would actually know of the movie.
link |
00:35:28.960
Awesome, awesome.
link |
00:35:29.800
Yeah, yeah, I said, I love the tango scene.
link |
00:35:31.920
I love Al Pacino's performance.
link |
00:35:34.680
It's a wonderful movie.
link |
00:35:35.840
Then Joe was saying, John Wick is better.
link |
00:35:39.360
So we to this day argue about this.
link |
00:35:41.440
I think it depends on what conscious state you're in
link |
00:35:44.920
that you would be ready and receptive to.
link |
00:35:46.960
But Sense of a Woman, I think it has one of the best monologues
link |
00:35:51.240
at the end of the movie that has ever been written
link |
00:35:54.520
or at least performed.
link |
00:35:57.000
When Al Pacino defends the younger.
link |
00:36:01.920
Yeah, I often think about that.
link |
00:36:05.880
There's been times in my life,
link |
00:36:08.080
I don't know about you,
link |
00:36:09.920
where I wish I had an Al Pacino in my life.
link |
00:36:12.520
Where integrity is really important in this life.
link |
00:36:18.200
It is.
link |
00:36:19.040
And sometimes you find yourself in places
link |
00:36:20.720
where there's pressure to sacrifice that integrity.
link |
00:36:25.520
And you want, what is it?
link |
00:36:28.240
Lieutenant Colonel or whatever he was to come in on your side
link |
00:36:34.760
and scream at everyone and say,
link |
00:36:36.360
what the hell are we doing here?
link |
00:36:38.480
Being, you know, unfortunately,
link |
00:36:40.680
British instead of having that slightly awkward,
link |
00:36:44.320
sort of huge grand gene,
link |
00:36:45.360
it's very at the opposite end of the spectrum
link |
00:36:48.760
of the remarkable feat of Al Pacino at the end of that scene.
link |
00:36:53.040
But, and yeah, integrity is,
link |
00:36:56.200
it's a challenging thing and I value it much.
link |
00:37:00.320
And I think it can take 20 years to build a reputation
link |
00:37:04.920
in two minutes to lose it.
link |
00:37:06.600
And there is nothing more that I value than that integrity.
link |
00:37:10.440
And, you know, if I'm ever wrong about anything,
link |
00:37:13.560
I truly don't want to be wrong for any longer
link |
00:37:16.840
than I have to be.
link |
00:37:19.400
You know, that's what being in some ways a scientist is.
link |
00:37:22.680
You're just driven by truth.
link |
00:37:25.440
And the irony relative to something like mathematics
link |
00:37:29.200
is that in science, you never find truth.
link |
00:37:31.880
What all you do in science
link |
00:37:33.880
is you discount the things that are likely to be untrue,
link |
00:37:38.040
leaving only the possibility of what could be true.
link |
00:37:42.240
But in math, you know, when you create, you know, a proof,
link |
00:37:46.640
it's a proof for, you know, from that point forward,
link |
00:37:51.800
there is truth in mathematics.
link |
00:37:54.320
And I think there's a beauty in that.
link |
00:37:57.000
But I kind of like the messiness of science
link |
00:38:00.240
because again, to me, it's less about the truth of the answer
link |
00:38:04.600
and it is more about the pursuit of questions.
link |
00:38:07.240
But their integrity becomes more and more important
link |
00:38:10.080
and it becomes more difficult.
link |
00:38:11.800
There's a lot of pressure,
link |
00:38:12.920
it's just like in the rest of the world,
link |
00:38:14.080
but there's a lot of pressures on a scientist.
link |
00:38:17.160
One is like funding sources.
link |
00:38:19.440
I've noticed this that, you know, money affects
link |
00:38:22.200
everyone's mind, I think.
link |
00:38:24.560
I've been always somebody that I believe money can't,
link |
00:38:28.320
you can't buy my opinion.
link |
00:38:31.480
I don't care how much money, billions or trillions.
link |
00:38:34.360
The, but that pressure is there
link |
00:38:37.000
and you have to be very cognizant of it
link |
00:38:38.760
and make sure that your opinion is not defined
link |
00:38:41.640
by the funding sources.
link |
00:38:43.360
And then the other is just your own success of, you know,
link |
00:38:48.240
for a couple of decades publishing an idea
link |
00:38:53.880
and then realizing at some point
link |
00:38:55.440
that that idea was wrong all along.
link |
00:38:57.920
And that's a tough thing for people to do.
link |
00:39:00.800
But that's also integrity, is to walk away,
link |
00:39:03.200
is to say that you were wrong.
link |
00:39:06.320
That doesn't have to be in some big dramatic way.
link |
00:39:08.880
It could be in a bunch of tiny ways along the way, right?
link |
00:39:12.800
Like reconfigure your intuition
link |
00:39:15.480
about a particular problem.
link |
00:39:18.800
That's, and all of that is integrity.
link |
00:39:20.520
When everybody in the room believes a certain thing,
link |
00:39:24.480
everybody in the community believes a certain thing
link |
00:39:27.440
to be able to still be open minded in the face of that.
link |
00:39:31.000
Yeah, and I think it comes down
link |
00:39:32.560
in some ways to the issue of ego,
link |
00:39:35.360
that you bond your correctness or your rightness,
link |
00:39:39.960
your scientific theory with your sense of ego.
link |
00:39:45.840
You know, I've never found it that difficult
link |
00:39:47.760
to let go of theories in the face of counter evidence,
link |
00:39:52.800
in part because I have such low self esteem.
link |
00:39:56.400
Well, I kind of like that.
link |
00:39:57.680
I always liked that combination.
link |
00:39:59.000
I have the same, I'm like very self critical,
link |
00:40:01.600
imposter syndrome, all those things,
link |
00:40:03.920
putting yourself below the podium,
link |
00:40:05.760
but at the same time having the ego
link |
00:40:08.120
that drives the ambition to work your ass off.
link |
00:40:11.040
Like some kind of weird drive,
link |
00:40:13.520
maybe like drive to be better.
link |
00:40:16.760
Like thinking yourself is not that great
link |
00:40:18.920
and always driving to be better.
link |
00:40:20.960
And then at the same time,
link |
00:40:22.040
because that can be paralyzing and exhausting and so on,
link |
00:40:25.960
at the same time just being grateful to be alive.
link |
00:40:28.360
But in the sciences, in the actual effort,
link |
00:40:31.320
never be satisfied, never think of yourself highly.
link |
00:40:33.960
That seems to be a nice combination.
link |
00:40:35.840
I very much hope that that is part of who I am.
link |
00:40:39.680
And I remain very quietly motivated and driven.
link |
00:40:44.400
And I, like you, love the idea of perfection
link |
00:40:47.960
and I know I will never achieve it,
link |
00:40:49.680
but I will never stop trying to.
link |
00:40:52.200
So similar to you, which sounds weird
link |
00:40:55.480
because there's all these videos of me on the internet.
link |
00:41:01.040
So I think I just naturally lean into the things
link |
00:41:04.360
I'm afraid of and I'm uncomfortable doing.
link |
00:41:07.200
Like I'm very afraid of talking to people
link |
00:41:09.040
and just even before talking to you today,
link |
00:41:12.640
just a lot of anxiety and all those kinds of things.
link |
00:41:16.040
How about talking to me?
link |
00:41:17.480
Yeah, yeah.
link |
00:41:18.320
Oh, like nervousness, fear in some cases,
link |
00:41:22.480
self doubt and all those kinds of things.
link |
00:41:24.480
But I do it anyway.
link |
00:41:25.920
So the reason I bring that up is you've launched a podcast.
link |
00:41:30.920
I have. Allow me to say,
link |
00:41:34.040
I think you're a great science communicator.
link |
00:41:36.200
So this challenge of being afraid
link |
00:41:43.200
or cautious of being in the public eye
link |
00:41:46.880
and yet having a longing to communicate
link |
00:41:50.280
some of the things you're excited about
link |
00:41:52.440
in the space of sleep and beyond.
link |
00:41:54.720
What's your vision with this project?
link |
00:41:56.960
With this project, I think firstly to that question,
link |
00:42:02.800
like you, I am always more afraid of not trying and trying.
link |
00:42:07.960
Yeah, that to me frightens me more.
link |
00:42:12.040
But with the podcast, I think really,
link |
00:42:16.000
I have two very simple goals.
link |
00:42:18.640
I want to try and democratize the science of sleep.
link |
00:42:23.000
And in doing so, my goal would be to try
link |
00:42:25.000
and reunite humanity with the sleep
link |
00:42:27.080
that it is so desperately bereft of.
link |
00:42:30.560
And if I can do that through a number of different means,
link |
00:42:35.520
the podcast is a little bit different than this format.
link |
00:42:38.520
It's going to be short form monologues from yours truly.
link |
00:42:45.200
That will last usually less than just 10 minutes.
link |
00:42:47.800
And I see it as simply a little slice of sleep goodness
link |
00:42:51.440
that can accompany your waking day.
link |
00:42:53.960
It's hard to know what is the right way
link |
00:42:56.400
to do science communication.
link |
00:42:58.440
Like your friend, mine, Andrew Huberman is does,
link |
00:43:03.680
he's an incredible human being.
link |
00:43:05.480
Oh gosh.
link |
00:43:06.320
So he does like two hours of,
link |
00:43:09.440
I wonder how many takes he does.
link |
00:43:10.680
I don't know, but it looks like he doesn't do any.
link |
00:43:12.840
Yeah, I suspect he's that magnificent of a human being.
link |
00:43:16.280
When I talk to him in person,
link |
00:43:18.920
he always generates intelligent words,
link |
00:43:21.600
well cited nonstop for hours.
link |
00:43:24.200
So I don't...
link |
00:43:25.720
He's a Gatlin gun of information and it's pristine.
link |
00:43:29.040
And passion and all those kinds of things.
link |
00:43:30.720
So that's an interesting medium.
link |
00:43:32.280
I wouldn't have, it's funny
link |
00:43:35.760
because I wouldn't have done it the way he's doing it.
link |
00:43:38.040
I wouldn't advise him to do it the way he's doing it.
link |
00:43:40.360
Cause I thought there's no way you could do what you're doing.
link |
00:43:43.840
Cause it's a lot of work,
link |
00:43:45.520
but he is like doing an incredible job of it.
link |
00:43:48.440
I just think it's the same with like Dan Carlin
link |
00:43:51.080
in hardcore history.
link |
00:43:52.160
I thought that the way Andrew is doing it
link |
00:43:56.680
would crush him the way it crushes Dan Carlin.
link |
00:44:00.840
So Dan has so much pressure on him to do a good job
link |
00:44:04.680
that he ends up publishing like two episodes a year.
link |
00:44:08.120
So that pressure can be paralyzing,
link |
00:44:10.080
the pressure of like putting out like
link |
00:44:13.560
strong scientific statements that that can be overwhelming.
link |
00:44:17.840
Now Andrew seems to be just plowing through anyway.
link |
00:44:21.560
If there's mistakes, he'll,
link |
00:44:23.240
he'll say there's corrections and so on.
link |
00:44:25.240
I just, I wonder,
link |
00:44:26.240
I actually haven't talked too much about it like psychologically.
link |
00:44:28.920
How difficult is it to put yourself out there
link |
00:44:32.000
for an hour to a week of just nonstop dropping knowledge.
link |
00:44:37.960
Any one sentence of which could be totally wrong.
link |
00:44:41.160
It could be a mistake.
link |
00:44:42.240
And there will be mistakes, you know?
link |
00:44:44.520
And I, you know, in the first edition of my book,
link |
00:44:47.440
there were errors that, you know,
link |
00:44:49.360
we corrected in the second edition too,
link |
00:44:52.400
but there will be probabilistically, you know,
link |
00:44:55.840
if you've got, you know, 10 facts per page of a book
link |
00:44:59.080
and you've got 350 pages,
link |
00:45:02.440
odds are it's probably not going to be
link |
00:45:05.240
utter perfection out the gate.
link |
00:45:07.400
And it will be the same way for Andrew too.
link |
00:45:11.720
But having the, the reverence of
link |
00:45:15.600
a humble mind
link |
00:45:19.400
and simply accepting the things that are wrong
link |
00:45:22.000
and correcting them and doing the right thing.
link |
00:45:23.920
I know that that's his mentality.
link |
00:45:26.640
I do want to say that I'm just kind of honored to be,
link |
00:45:30.280
it's like, it's a cool group of like scientific people
link |
00:45:34.800
that I'm fortunate enough to now be interacting with.
link |
00:45:37.880
It's you and Andrew and David Sinclair
link |
00:45:41.200
has been thinking about throwing his hat in the ring.
link |
00:45:43.120
Oh, I hope so.
link |
00:45:43.960
It is another one of those very special people in the world.
link |
00:45:47.320
So it's cool because podcasts are, it's cool.
link |
00:45:51.080
It's a, it's such a powerful medium of communication.
link |
00:45:53.440
It's much freer than more constrained
link |
00:45:56.520
like publications and so on.
link |
00:45:58.400
Or it's much more accessible and inspiring than like,
link |
00:46:01.840
I don't know, conference presentations or lectures.
link |
00:46:04.000
And so it's a really exciting medium to me.
link |
00:46:06.880
And it's cool that there's this like group of people
link |
00:46:08.840
that are becoming friends and putting stuff out there
link |
00:46:12.720
and supporting each other.
link |
00:46:13.640
So it's fun to also watch
link |
00:46:16.800
how that's going to evolve in your case.
link |
00:46:18.960
Cause it will wonder, it'll be too among.
link |
00:46:20.840
Oh, Dival, I think is the answer to that.
link |
00:46:24.960
Well, I mean, some of it is persistence
link |
00:46:27.720
through the challenges that we've been talking about,
link |
00:46:30.240
which is like,
link |
00:46:31.240
I think I've got a lot to learn.
link |
00:46:32.440
Yeah.
link |
00:46:33.280
But I will persist.
link |
00:46:35.720
Can I ask you some detailed stuff you mentioned?
link |
00:46:38.080
Oh my goodness, go anywhere you wish with sleep.
link |
00:46:41.600
So I'm a big fan of coffee and caffeine.
link |
00:46:45.280
And I've been, especially in the last few days,
link |
00:46:47.800
consuming a very large amount.
link |
00:46:50.160
And I'm cognizant of the fact that
link |
00:46:54.280
my body is affected by caffeine
link |
00:46:56.280
different than the anecdotal information
link |
00:46:59.000
that other people tell me.
link |
00:47:00.760
I seem to be not at all affected by it.
link |
00:47:03.920
It's almost,
link |
00:47:06.520
it feels like more like a ritual
link |
00:47:09.280
than it is a chemical boost to my performance.
link |
00:47:12.120
Like I can drink several cups of coffee right before bed
link |
00:47:15.400
and just knock out anyway.
link |
00:47:17.720
I'm not sure if it's biological chemical
link |
00:47:20.200
or it has to do with just the fact
link |
00:47:21.520
that I'm consuming huge amounts of caffeine.
link |
00:47:24.320
All that to say,
link |
00:47:28.160
what do you think is the relationship
link |
00:47:29.520
between coffee and sleep, caffeine and sleep?
link |
00:47:32.880
If there's an interesting distinction there.
link |
00:47:34.400
There is a distinction.
link |
00:47:35.640
So I think the first thing to say,
link |
00:47:37.560
which is going to sound strange coming from me
link |
00:47:40.160
is drink coffee.
link |
00:47:43.600
The health benefits associated with drinking coffee
link |
00:47:46.440
are really quite well established now.
link |
00:47:51.120
But I think that the counterpoint to that,
link |
00:47:54.160
well firstly, the dose and the timing make the poison
link |
00:47:57.840
and I'll perhaps come back to that in just a second.
link |
00:48:01.200
But for coffee, it's actually not the caffeine.
link |
00:48:06.200
So a lot of people have asked me
link |
00:48:09.360
about this rightful paradox between the fact that sleep
link |
00:48:12.640
provides all of these incredible health benefits
link |
00:48:15.360
and then coffee, which can have a deleterious impact
link |
00:48:19.200
on your sleep, has a whole collection of health benefits.
link |
00:48:22.920
Many of them, Venn diagram overlapping with those
link |
00:48:25.760
that sleep provides, how on earth can you reconcile those two?
link |
00:48:30.000
And the answer is that, well, the answer is very simple.
link |
00:48:33.640
The answer is very simple, it's called antioxidants.
link |
00:48:37.760
That it turns out that for most people in Western civilization
link |
00:48:41.800
because of diet not being quite what it should be,
link |
00:48:45.800
the major source through which they obtain antioxidants
link |
00:48:50.160
is the coffee bean.
link |
00:48:51.280
So the humble coffee bean has now been asked to carry
link |
00:48:55.440
the astronomical weight of serving up the large majority
link |
00:49:00.320
of people's antioxidant needs.
link |
00:49:02.800
And you can see this if, for example,
link |
00:49:05.480
you look at the health benefits of decaffeinated coffee,
link |
00:49:09.080
it has a whole constellation
link |
00:49:10.920
of really great health benefits too.
link |
00:49:12.840
So it's not the caffeine, and that's why I liked
link |
00:49:15.080
what you said, this sort of separation of church
link |
00:49:17.880
and state between coffee and caffeine.
link |
00:49:20.640
It's not the caffeine, it's the coffee bean itself
link |
00:49:24.080
that provides those health benefits.
link |
00:49:25.600
But coming back to how it impacts sleep,
link |
00:49:30.320
it impacts sleeping probably at least three different ways.
link |
00:49:34.080
The first is that for most people,
link |
00:49:37.560
caffeine can make it obviously a little harder
link |
00:49:39.960
to fall asleep, caffeine can make it harder to stay asleep.
link |
00:49:44.560
But let's say that you are one of those individuals
link |
00:49:46.600
and I think you are, and you can say,
link |
00:49:48.560
look, I can have three or four espressos with dinner
link |
00:49:51.240
and I fall asleep just fine,
link |
00:49:52.800
and I stay asleep soundly across the night,
link |
00:49:55.000
so there's no problem.
link |
00:49:56.720
The downside there is that even if that is true,
link |
00:50:00.360
the amount of deep sleep that you get
link |
00:50:02.680
will not be as deep, and so you will actually lose
link |
00:50:05.240
somewhere between 10 to 30% of your deep sleep
link |
00:50:08.520
if you drink caffeine in the evening.
link |
00:50:11.320
So to give you some context to drop your deep sleep
link |
00:50:14.880
by let's say 20%, I'd probably have to age you by 15 years,
link |
00:50:19.320
or you could do it every night with a cup of coffee.
link |
00:50:22.560
I think the fourth component that is perhaps less well
link |
00:50:25.960
understood about coffee is its timing,
link |
00:50:28.880
and that's why I was saying the timing and the dose
link |
00:50:30.640
make the poison, the dose, by the way,
link |
00:50:32.920
once you get past about three cups of coffee a day,
link |
00:50:35.840
the health benefits actually start to turn down
link |
00:50:38.440
in the opposite direction.
link |
00:50:40.240
So there is a U shaped function,
link |
00:50:42.000
it's sort of the Goldilocks syndrome,
link |
00:50:44.240
not too little, not too much, just the right amount.
link |
00:50:48.080
The second component is the timing though.
link |
00:50:50.720
Caffeine has half life of about five to six hours,
link |
00:50:55.280
meaning that after five to six hours,
link |
00:50:57.840
50% of that on average for the average adult
link |
00:51:01.200
is still in the system,
link |
00:51:02.520
which means that it has a quarter life of 10 to 12 hours.
link |
00:51:06.080
So in other words, if you have a coffee at noon,
link |
00:51:08.320
a quarter of that caffeine is still circulating
link |
00:51:10.600
in your brain at midnight.
link |
00:51:12.640
So having a cup of coffee at noon,
link |
00:51:14.800
one could argue is the equivalent
link |
00:51:16.240
of tucking yourself into bed at midnight,
link |
00:51:18.080
and before you turn the light out,
link |
00:51:19.600
you swig a quarter of a cup of coffee.
link |
00:51:22.240
But that doesn't still answer your question
link |
00:51:24.360
as to why are you so immune?
link |
00:51:26.240
So I'm someone who is actually unfortunately
link |
00:51:28.200
very sensitive to caffeine.
link |
00:51:29.560
And if I have, you know, even two cups of coffee
link |
00:51:33.200
in the morning, I don't sleep as well that night.
link |
00:51:37.280
And I find it miserable because I love the smell of coffee,
link |
00:51:40.720
I love the routine, I love the ritual.
link |
00:51:43.600
I think I would love to be invested in it.
link |
00:51:46.280
It's just terrible for my sleep.
link |
00:51:47.680
So I switched to decaf.
link |
00:51:49.480
There is a difference from one individual to the next,
link |
00:51:52.680
and it's controlled by a set of liver enzymes
link |
00:51:56.680
called cytochrome P450 enzymes.
link |
00:52:00.760
And there is a particular gene
link |
00:52:03.080
that if you have a different sort of version of this gene,
link |
00:52:06.680
it's called CYP1A2.
link |
00:52:11.600
That gene will determine the speed
link |
00:52:14.760
of the clearance of caffeine from your system.
link |
00:52:18.120
Some people will have a version of that gene
link |
00:52:20.320
that is very effective and efficient
link |
00:52:23.080
at clearing that caffeine.
link |
00:52:24.720
And so their half life could be as short as two hours
link |
00:52:28.480
rather than five to six hours.
link |
00:52:30.960
Other people, hands up Matt Walker,
link |
00:52:34.120
have a version of that gene
link |
00:52:35.720
that is not very effective at clearing out the caffeine.
link |
00:52:40.400
And therefore their half life sort of sensitivity
link |
00:52:43.720
could be somewhere between, you know, eight to nine hours.
link |
00:52:48.160
So we understand that there are individual differences,
link |
00:52:50.760
but overall I guess the top line here is drink coffee
link |
00:52:56.600
and understand that it's not the caffeine,
link |
00:52:58.440
it's the coffee that's the benefit
link |
00:53:00.080
and the dose makes the poison.
link |
00:53:01.320
Is there some aspect to it that it's like a muscle
link |
00:53:04.880
in terms of all the combination of letters
link |
00:53:07.800
and numbers that you just said?
link |
00:53:09.080
Is there some aspect that if I can improve
link |
00:53:13.880
the quarter life, the half life,
link |
00:53:15.760
I could decrease that number if I just practice.
link |
00:53:19.120
Like I drink a lot of coffee, it's just like habit,
link |
00:53:22.680
it alters how your body's able to get rid of the caffeine.
link |
00:53:27.200
Not how the body is able to get rid of the caffeine,
link |
00:53:30.200
but it does alter how sensitive the body is to the caffeine.
link |
00:53:34.560
And it's not at the level of the enzyme degrading the caffeine,
link |
00:53:38.840
it's at the level of the receptors
link |
00:53:41.560
that caffeine will act upon.
link |
00:53:44.200
Now it turns out that those are called adenosine receptors
link |
00:53:47.040
and maybe we can speak about what adenosine is
link |
00:53:49.160
and sleep pressure and all of that good stuff.
link |
00:53:51.240
But as you start to drink more and more coffee,
link |
00:53:56.400
the body tries to fight back
link |
00:53:59.040
and it happens with many different drugs by the way
link |
00:54:01.160
and it's called tolerance.
link |
00:54:03.200
And so one of the ways that your body becomes tolerant
link |
00:54:06.720
to a drug is that the receptors that the drug is binding to,
link |
00:54:10.160
these sort of welcome sites,
link |
00:54:11.440
these sort of picture mitts, as it were,
link |
00:54:14.360
that receive the drug,
link |
00:54:16.360
those start to get taken away from the surface of the cell.
link |
00:54:21.680
And it's what we call receptor internalization.
link |
00:54:25.120
So the cell starts to think, gee whiz,
link |
00:54:27.880
there's a lot of stimulation going on, this is too much.
link |
00:54:31.480
So I'm just going to,
link |
00:54:33.040
when normally I would coat my cell with,
link |
00:54:36.240
let's just say five of these receptors for argument's sake,
link |
00:54:40.680
things are going a little bit too ballistic right now,
link |
00:54:43.320
I'm going to take away at least two of those receptors
link |
00:54:46.120
and downscale it to just having three of those.
link |
00:54:49.160
And now you need two cups of coffee to get the same effect
link |
00:54:52.880
that one cup of coffee got you before.
link |
00:54:55.560
And that's why then when you go cold turkey on coffee,
link |
00:55:01.040
all of a sudden the system has equilibrated itself
link |
00:55:05.400
to expecting X amount of stimulation.
link |
00:55:08.560
And now all of that stimulation is gone.
link |
00:55:10.160
So it's now got too few receptors
link |
00:55:12.960
and you have a caffeine withdrawal syndrome.
link |
00:55:15.680
And that's why, for example, with drugs of abuse,
link |
00:55:18.560
things like heroin, when people go into abstinence,
link |
00:55:23.720
as they're sort of moving into their addiction,
link |
00:55:26.720
they will build up a progressive tolerance to that drug.
link |
00:55:30.680
So they need to take more of it to get the same high.
link |
00:55:34.160
But then if they go cold turkey for some period of time,
link |
00:55:38.200
the system goes back to being more sensitive again.
link |
00:55:40.680
It starts to repopulate the surface of the cell
link |
00:55:43.440
with these receptors.
link |
00:55:44.680
But now when they reuse and they fall off the wagon,
link |
00:55:47.720
if they go back to the same dose
link |
00:55:49.480
that they were using before 10 weeks ago
link |
00:55:53.120
or three months ago,
link |
00:55:54.760
that dose can kill them, they can have an overdose.
link |
00:55:58.200
Even though they were using the same amount
link |
00:56:00.360
at those two different times,
link |
00:56:02.280
the difference is that it's not the dose of the drug,
link |
00:56:05.840
it's the sensitivity of the system.
link |
00:56:08.160
And that's the same thing that we see with caffeine.
link |
00:56:11.040
In terms of training the muscle, as it were,
link |
00:56:13.440
is the system becomes less sensitive, can calibrate.
link |
00:56:17.640
Is there a time, the number of hours before bed,
link |
00:56:22.920
that's a safe bet to most people to recommend,
link |
00:56:27.520
you shouldn't drink caffeine this many hours?
link |
00:56:31.240
Like, is there an average half life
link |
00:56:33.480
that you should be aiming at?
link |
00:56:35.480
Or is this advice kind of impossible
link |
00:56:38.080
because there's so much variability?
link |
00:56:39.600
There is a huge variability.
link |
00:56:41.280
And I think everyone themselves,
link |
00:56:43.600
to a degree knows it,
link |
00:56:45.320
although I'll put a caveat on that too,
link |
00:56:48.000
because it's a slightly dangerous point.
link |
00:56:50.400
So the recommendation for the average adult
link |
00:56:53.200
and who, where is the average adult in society?
link |
00:56:55.640
There is no such thing.
link |
00:56:56.480
But for the average adult,
link |
00:56:58.440
it would be probably cutting yourself off
link |
00:57:00.320
maybe 10 hours before.
link |
00:57:02.840
So assuming a normative bedtime in society,
link |
00:57:06.200
I would say try to stop drinking caffeine before 2 p.m.
link |
00:57:10.840
and just keep an eye out.
link |
00:57:13.080
And if you're struggling with sleep,
link |
00:57:14.440
dial down the caffeine and see if it makes a difference.
link |
00:57:18.000
Can I ask you about sleep and learning?
link |
00:57:22.440
So how does sleep affect learning?
link |
00:57:25.360
Sleep before learning, sleep after learning,
link |
00:57:30.400
which are both fascinating kind of dynamics
link |
00:57:33.120
of the mind's interaction with this extra conscious state.
link |
00:57:36.160
Yeah, sleep is profoundly and very intimately related
link |
00:57:42.320
to your memory systems and your informational systems.
link |
00:57:45.720
The first is you just mentioned is that sleep before learning
link |
00:57:50.760
will essentially prepare your brain
link |
00:57:53.440
almost like a dry sponge,
link |
00:57:55.120
ready to sort of initially soak up new information.
link |
00:57:59.200
In other words, you need sleep before learning
link |
00:58:01.240
to effectively imprint information into the brain
link |
00:58:04.960
to lay down fresh memory traces.
link |
00:58:08.000
And without sleep, the memory circuits of the brain,
link |
00:58:11.080
and we know we've studied these memory circuits,
link |
00:58:14.040
will essentially become waterlogged,
link |
00:58:17.080
as it were for the sponge analogy,
link |
00:58:18.560
and you can't absorb the information as effectively.
link |
00:58:24.000
So you need sleep before learning,
link |
00:58:26.400
but you also need sleep, unfortunately, after learning too,
link |
00:58:30.280
to then take those freshly minted memories
link |
00:58:33.680
and effectively hit the save button on them,
link |
00:58:36.280
but it's nowhere near as quick as a digital system.
link |
00:58:38.800
It takes hours because it's a physical biological change
link |
00:58:42.200
that happens at the level of brain cells.
link |
00:58:45.120
But sleep after learning will cement and solidify
link |
00:58:49.600
that new memory into the neural architecture of the brain,
link |
00:58:53.400
therefore making it less likely to be forgotten.
link |
00:58:57.000
So I often think of sleep in that way as,
link |
00:59:01.360
it's almost sort of future proofing information in your way.
link |
00:59:07.040
Well, it means that it gives it a higher degree of assurance
link |
00:59:13.160
to be remembered in the future,
link |
00:59:15.120
rather than go through the sort of degradation
link |
00:59:19.440
that we think of as forgetting.
link |
00:59:22.240
So the brain has, in some ways, by default, there is forget.
link |
00:59:28.040
And actually, I would love to,
link |
00:59:29.960
I was going to say sleep is relevant for memory
link |
00:59:32.000
in three different ways,
link |
00:59:33.320
but I'm going to amend that and say there's four different ways,
link |
00:59:36.920
which is learning, maintaining, memorizing,
link |
00:59:43.040
abstraction, assimilation, association, then forgetting,
link |
00:59:47.840
which the last one sounds oxymoronic
link |
00:59:50.520
based on the form of three, but I'll see if I can explain.
link |
00:59:53.560
So sleep after learning then sort of sets that information
link |
00:59:58.560
like amber in solidification.
link |
01:00:04.040
The third benefit, however, is that sleep we've learned
link |
01:00:08.320
more recently is much more intelligent
link |
01:00:10.320
than we ever gave it credit for.
link |
01:00:12.400
Sleep doesn't simply just take individual memories
link |
01:00:16.080
and strengthen them.
link |
01:00:17.640
Sleep will then intelligently integrate and crosslink
link |
01:00:21.960
and associate that information together.
link |
01:00:24.920
And it's almost like informational alchemy
link |
01:00:28.360
so that you wake up the next morning
link |
01:00:30.880
with a revised, mind wide web of associations.
link |
01:00:36.400
And that's probably the reason that you've never been told
link |
01:00:39.640
to stay awake on a problem.
link |
01:00:43.080
And in every language that I've inquired about that phrase
link |
01:00:46.600
or something very similar seems to exist,
link |
01:00:49.680
which means to me that this creative associative benefit
link |
01:00:54.300
of sleep transcends cultural boundaries.
link |
01:00:56.840
It is a common experience across humanity.
link |
01:01:02.300
Now I should note that I think the French translation
link |
01:01:05.200
of that is much closer to you.
link |
01:01:07.400
I think you sleep with a problem, whereas the British,
link |
01:01:10.280
you sleep on a problem.
link |
01:01:11.400
The French, you sleep with a problem.
link |
01:01:12.960
I think it says so much about the romantic difference
link |
01:01:15.120
between the British and the French, but let's not go there.
link |
01:01:19.640
That's brilliant.
link |
01:01:20.480
So such a subtle, but such a fundamental difference.
link |
01:01:23.480
Yeah, gorgeous.
link |
01:01:24.840
Yeah, goodness me.
link |
01:01:25.680
Sleep with the problem.
link |
01:01:27.240
Yes, exactly.
link |
01:01:28.440
It's right along on the French.
link |
01:01:31.440
So, and we can sort of double click on any one of these
link |
01:01:34.960
and go into detail, but the fourth,
link |
01:01:38.660
I became really enchanted by about eight years ago
link |
01:01:44.080
in our research, which was this idea of forgetting.
link |
01:01:48.440
And I started to think that forgetting may be the price
link |
01:01:52.920
that we pay for remembering.
link |
01:01:56.480
And in that sense, there is an enormous benefit
link |
01:02:03.360
to letting go.
link |
01:02:06.000
And you may be thinking, that sounds ridiculous.
link |
01:02:08.440
I don't want to forget.
link |
01:02:09.760
In fact, my biggest problem is I keep forgetting things,
link |
01:02:13.280
but the brain will we believe has a finite storage capacity.
link |
01:02:20.560
We can't prove it yet, but my suspicion is
link |
01:02:22.560
that that's probably true.
link |
01:02:23.520
It doesn't have an infinite storage capacity.
link |
01:02:25.600
It has constraints.
link |
01:02:27.840
If that's the case, we can't simply go through life
link |
01:02:31.600
being constantly informational aggregators,
link |
01:02:37.800
unless we are programmed to say,
link |
01:02:39.880
we've got a hard drive space of about 85 to 90 years
link |
01:02:43.200
and we're good and we can do that.
link |
01:02:44.840
Maybe that's true.
link |
01:02:46.000
I don't think that's true.
link |
01:02:47.000
I think forgetting is an incredibly good and useful thing.
link |
01:02:50.680
So for example, it's not beneficial
link |
01:02:54.280
from an evolutionary perspective for me to remember
link |
01:02:57.160
where I parked my car three years ago.
link |
01:03:00.880
So it's important that I can remember today's parking spot,
link |
01:03:04.840
but I don't want to have the junk DNA
link |
01:03:08.200
from a memory perspective of where I parked my car
link |
01:03:13.000
two years ago.
link |
01:03:15.080
Now, I actually have in some ways a problem with forgetting.
link |
01:03:18.240
I'm, and again, I'm not trying to sort of be laudatory,
link |
01:03:20.560
but I tend not to forget too many things.
link |
01:03:25.000
And I don't think that that's a good thing.
link |
01:03:27.240
And there was a wonderful neurologist, Luria,
link |
01:03:31.560
who wrote a book called The Mind of the Pneumonocyst.
link |
01:03:35.480
And it was a brilliant book,
link |
01:03:37.960
both because it was written exquisitely,
link |
01:03:40.720
but he was studying these sort of memory savants
link |
01:03:44.880
who basically could remember everything that he gave them.
link |
01:03:49.560
And he tried to find a chink in their armor.
link |
01:03:53.680
And the first half of the book is essentially about him
link |
01:03:57.000
seeing how far he can push them before they fail.
link |
01:04:01.840
And he never found that place.
link |
01:04:03.880
He could never find a place where they stopped remembering.
link |
01:04:09.120
And then in his brilliance,
link |
01:04:10.920
he turned the question on its head.
link |
01:04:13.200
He said, not what is the benefit of constantly remembering,
link |
01:04:17.800
but instead what is the detriment to never forgetting?
link |
01:04:22.320
And when you start to realize his descriptions
link |
01:04:24.800
of those individuals,
link |
01:04:26.160
it's probably a life that you would not want.
link |
01:04:29.640
But it's as fascinating both from a human perspective,
link |
01:04:32.000
but also AI perspective.
link |
01:04:33.560
There's a big challenge in the machine learning community
link |
01:04:38.400
of how to build systems that are able to remember
link |
01:04:40.720
for prolonged periods of time,
link |
01:04:42.720
lifelong continuous learning.
link |
01:04:45.000
So where you build up information over time.
link |
01:04:48.200
So memory is one of the biggest open problems
link |
01:04:51.240
in AI and machine learning.
link |
01:04:54.680
But at the same time,
link |
01:04:55.920
the right way to formulate memory is actually forgetting
link |
01:05:00.240
because you have to be exceptionally selective
link |
01:05:03.520
at which kind of stuff you remember.
link |
01:05:05.680
And that's where the step of a simulation integration
link |
01:05:08.200
that you're referring to is really important.
link |
01:05:10.000
I mean, we forget most of the things.
link |
01:05:12.800
And the question is exactly the cost of forgetting
link |
01:05:16.760
at the very edge of stuff that could be important
link |
01:05:20.480
or could not be.
link |
01:05:21.840
How do we remember or not those things?
link |
01:05:24.240
Like for example, I've, you know, doing a podcast,
link |
01:05:28.440
I've become cognizant of one feature of my forgetting
link |
01:05:32.480
that's been problematic,
link |
01:05:34.240
which is I forget names and titles of books and so on.
link |
01:05:39.240
So when I read, I remember ideas.
link |
01:05:43.440
I remember quotes.
link |
01:05:45.600
I remember statements and like,
link |
01:05:47.640
that's the space in which I'm thinking.
link |
01:05:50.280
But when you communicate to others,
link |
01:05:52.960
you have to say this person in this book said that.
link |
01:05:56.560
So it's the same thing with like Andrew Huberman
link |
01:05:59.200
is masterful at this.
link |
01:06:01.040
It's this important academia,
link |
01:06:02.400
remembering the authors of a paper
link |
01:06:04.200
and the title of the paper as part of remembering the idea.
link |
01:06:09.000
And I've been feeling the cost of not being able
link |
01:06:12.920
to naturally remember those things.
link |
01:06:15.440
And so that's something I need to sort of work on.
link |
01:06:17.920
But that's an example with faces.
link |
01:06:20.040
Yes, very good at faces.
link |
01:06:21.480
But not good with names.
link |
01:06:23.000
So I am exactly like you.
link |
01:06:25.080
And there is, you know, an understanding of that
link |
01:06:27.400
in the brain too.
link |
01:06:28.840
We understand that there is partitioning of those
link |
01:06:31.560
in terms of the territory of the brain
link |
01:06:33.200
that takes care of faces and facts and places
link |
01:06:36.040
and that they can be separate.
link |
01:06:37.920
So I will never forget a face.
link |
01:06:40.520
But, you know, and as I said, I usually forget very little.
link |
01:06:44.400
But for some reason, names are a struggle.
link |
01:06:47.560
I think in some ways
link |
01:06:48.400
because I'm probably just a slightly anxious person.
link |
01:06:50.880
So when you first meet someone,
link |
01:06:52.120
which is usually the time when a name is introduced,
link |
01:06:55.320
you know, you were saying you were sort of anxious
link |
01:06:57.200
maybe about sort of sitting down with me.
link |
01:06:59.680
But I find that a little bit, you know, activating.
link |
01:07:04.320
And so it's not as though there's anything wrong with my memory.
link |
01:07:07.240
It's just the emotional state I'm in
link |
01:07:09.400
when I'm first meeting someone.
link |
01:07:10.680
You know, it's a little bit, it's hoping.
link |
01:07:12.680
But I will never forget the face.
link |
01:07:14.440
But I completely relate to that
link |
01:07:16.440
because I almost don't hear people's names
link |
01:07:19.040
when they tell me because I'm so anxious.
link |
01:07:21.320
Yeah, yeah.
link |
01:07:22.800
But I think there's certain quirks of social interaction
link |
01:07:27.200
that show that you care about the person,
link |
01:07:30.360
that you remember that person,
link |
01:07:31.760
that they matter to you, they had an impact on you.
link |
01:07:35.480
And one of the ways to show that is you remember their name.
link |
01:07:38.640
And, but that's a quirk to me because there's,
link |
01:07:41.840
a lot of people I meet have a deep impact on me.
link |
01:07:46.080
But they, I can't communicate that unless I know their name,
link |
01:07:50.640
unless I know some of the details that,
link |
01:07:55.960
that we humans seem to use to communicate
link |
01:07:58.640
that we remember each other.
link |
01:08:00.120
What I remember well is the feeling we shared,
link |
01:08:04.920
is the experience we shared.
link |
01:08:07.440
What I don't remember well is the detailed labels
link |
01:08:10.440
of those experiences.
link |
01:08:12.040
And I need to certainly work on that.
link |
01:08:14.040
I don't know.
link |
01:08:15.000
I think it's, you know, just allowing yourself to be an eight
link |
01:08:19.240
and who you are is also a beautiful thing too.
link |
01:08:22.640
I'm not suggesting it's not important
link |
01:08:24.560
to try and better oneself and,
link |
01:08:26.880
but I also sometimes worry about the misery
link |
01:08:29.720
that that puts us in.
link |
01:08:31.040
But like you, I will, I do struggle with them,
link |
01:08:35.920
but I know for the first time when we met in the lobby,
link |
01:08:40.760
I know exactly what you look like.
link |
01:08:43.680
I know that you were wearing headphones.
link |
01:08:45.240
I know the shape and the size of those headphones.
link |
01:08:47.600
You didn't have your black jacket on.
link |
01:08:49.040
I know exactly what the weave of your shirt looked like.
link |
01:08:51.640
I know what your shoes look like.
link |
01:08:53.640
And I knew exactly the height of your,
link |
01:08:56.040
the end of your pants from the top of your shoes.
link |
01:08:59.520
And so those things I don't forget, you know,
link |
01:09:02.360
and I can remember when people,
link |
01:09:04.720
I met people, you know, two years ago
link |
01:09:06.440
and I'll say, oh, yes, we met there.
link |
01:09:08.320
And I remember you had those fantastic, you know, boots on.
link |
01:09:12.280
I thought they were pretty great pair of boots, you know,
link |
01:09:15.000
and they're like, how do you,
link |
01:09:15.920
I didn't even remember what I was wearing that day.
link |
01:09:18.600
It's fascinating.
link |
01:09:19.760
Yeah, I'm the exact the same way,
link |
01:09:21.080
but you can't, until we have neural link
link |
01:09:23.520
or something like that,
link |
01:09:24.360
we can't communicate that you remember all those things.
link |
01:09:26.320
I know that's what I want to see.
link |
01:09:28.120
You have to be able to use tricks
link |
01:09:29.840
of human communication for that.
link |
01:09:31.480
But so that, I mean, that's the,
link |
01:09:33.800
it ultimately is a trick of like,
link |
01:09:35.800
which to remember, which to forget.
link |
01:09:37.440
Right.
link |
01:09:38.280
And the forgetting is so, it's so fascinating to say this.
link |
01:09:41.080
I mean, it seems to be deeply connected
link |
01:09:44.520
to that assimilation process.
link |
01:09:46.680
So forgetting, you try to fit all the new stuff
link |
01:09:50.640
into this big web of the old stuff
link |
01:09:55.040
and the things that don't fit, you throw out.
link |
01:09:58.280
I think the assimilation,
link |
01:10:00.080
the way I've been thinking about it with sleep,
link |
01:10:02.120
and it's particularly sort of dream sleep
link |
01:10:03.720
that we think can help with this assimilation,
link |
01:10:07.360
is that during wake,
link |
01:10:09.680
we have one version of associative processing.
link |
01:10:13.600
And what I mean by that is we see
link |
01:10:14.880
the most obvious connections.
link |
01:10:17.200
So I think of wakefulness as a Google search gone right.
link |
01:10:22.200
Whereas I see dream sleep as doing something very different.
link |
01:10:26.960
I think dream sleep is a little bit
link |
01:10:28.520
like group therapy for memories,
link |
01:10:31.040
that everyone gets a name badge,
link |
01:10:33.440
and sleep gathers in all of the individual pieces of the day.
link |
01:10:37.440
And it sort of starts to get you to forces you, in fact,
link |
01:10:41.240
to speak to the people, not at the front of the room,
link |
01:10:43.160
that you think you've got the most obvious connection with,
link |
01:10:45.560
but to speak with the people all the way
link |
01:10:47.200
at the back of the room, that at first you think,
link |
01:10:49.000
I've got no connection to sleep.
link |
01:10:51.080
You think I've got no obvious connection with them at all.
link |
01:10:54.480
But once you get chatting with them,
link |
01:10:56.600
you learn that you do have
link |
01:10:57.920
a very distant, non obvious connection,
link |
01:10:59.960
but it's still a connection non the same.
link |
01:11:02.720
And it's almost as though you're doing a Google search
link |
01:11:05.280
where I input Lex Friedman,
link |
01:11:08.640
and it doesn't take me to the first page of your home site.
link |
01:11:12.120
It takes me to page 20,
link |
01:11:13.840
which is about some field hockey game at Utah.
link |
01:11:16.920
It turns out that there actually is a link if I look at it.
link |
01:11:20.240
It's a distant, non obvious one.
link |
01:11:22.320
And to me, I find that exciting
link |
01:11:24.160
because when you fuse things together
link |
01:11:25.840
that shouldn't normally go together,
link |
01:11:27.760
but when they do, they cause marked advances
link |
01:11:30.080
in evolutionary fitness,
link |
01:11:31.600
it sounds like the biological basis of creativity.
link |
01:11:34.960
And that's exactly what I think dream sleep
link |
01:11:37.520
and the algorithm of dream sleep is designed to do.
link |
01:11:40.600
It's not a Boolean like system
link |
01:11:42.600
where you have the sort of assumptions of true and false.
link |
01:11:47.600
Maybe it's more fuzzy logic system.
link |
01:11:50.680
And I think REM sleep is a perfect environment
link |
01:11:53.920
within which we do, it's almost like memory pinball.
link |
01:11:57.760
You get the information that you've learned during the day
link |
01:12:00.720
and then you pull the lever back
link |
01:12:02.080
and you shoot it up into the attic of your brain.
link |
01:12:06.000
This cortex filled with all of your past historical knowledge
link |
01:12:10.000
and you start to bounce it around
link |
01:12:11.400
and see where one of those things lights up
link |
01:12:13.400
and you build a new connection there
link |
01:12:14.760
and you build another one there too.
link |
01:12:16.240
You're developing schemas.
link |
01:12:18.240
And so in that way, I think you could argue,
link |
01:12:22.000
we dream, therefore we are.
link |
01:12:25.240
Yeah, so in terms of this line between learning
link |
01:12:30.240
and thinking through a new thing
link |
01:12:32.240
that seems to be deeply connected,
link |
01:12:35.240
there's this legendary engineer named Jim Keller
link |
01:12:40.240
who keeps yelling at me about this.
link |
01:12:41.240
He says it's very effective.
link |
01:12:43.240
He likes to, for difficult problems before bed,
link |
01:12:47.240
think about that difficult problem.
link |
01:12:49.240
We're not talking about like drama, work
link |
01:12:51.240
or all that kind of stuff.
link |
01:12:52.240
No, like a scientific for him engineering problem.
link |
01:12:56.240
He likes to like intensely think about it
link |
01:12:59.240
and to prime his mind before sleep and then go to sleep.
link |
01:13:04.240
And then he finds that the next day,
link |
01:13:08.240
he's able to think much clearer
link |
01:13:10.240
and there's new ideas that come, but also just,
link |
01:13:13.240
I guess it's more well integrated.
link |
01:13:16.240
And sometimes during the process of like,
link |
01:13:20.240
he's able to like wake up and like seeing new insights.
link |
01:13:25.240
That's right.
link |
01:13:26.240
If he's deeply sort of aggressively thinking through a problem.
link |
01:13:29.240
And there's many scientific demonstrations of this.
link |
01:13:34.240
The Mendelea with a periodic table of elements,
link |
01:13:38.240
you know, he was trying for months to understand.
link |
01:13:41.240
I mean, talk about a ecumenical problem of epic proportions.
link |
01:13:47.240
Here's your question today.
link |
01:13:49.240
You have to understand how all of the known elements
link |
01:13:52.240
in the universe fit together in a logical way.
link |
01:13:55.240
Good luck, take care.
link |
01:13:56.240
It was non trivial at the time.
link |
01:13:58.240
And he would try and try.
link |
01:13:59.240
He was so obsessed with it.
link |
01:14:01.240
He created playing cards with all of the different elements on.
link |
01:14:05.240
And then he would go on these long train journeys around Europe
link |
01:14:09.240
and he would just sort of deal these cards in front of them
link |
01:14:12.240
and he would shuffle them shuffling and shuffling
link |
01:14:15.240
and he would just try to see if he could find what the answer was.
link |
01:14:19.240
And then so the story goes, you know, he fell asleep
link |
01:14:23.240
and he had a dream.
link |
01:14:24.240
And in that dream, you know, all of these elements
link |
01:14:27.240
started to dance and play around
link |
01:14:29.240
and they snapped into a logical grid, you know,
link |
01:14:32.240
atomic weights, et cetera, et cetera.
link |
01:14:35.240
And it wasn't his waking brain that solved the problem.
link |
01:14:41.240
It was his sleeping brain that solved the impenetrable problem
link |
01:14:44.240
that his waking brain could not.
link |
01:14:46.240
And there's been, you know, even in the arts and in music
link |
01:14:50.240
some wonderful dreams.
link |
01:14:52.240
You know, Frankenstein, Mary Shelley's epic Gothic novel
link |
01:14:55.240
came to her in a dream at Lord Byron's home.
link |
01:14:59.240
And then we've got, you know, Paul McCartney.
link |
01:15:05.240
Yesterday the song came to him in a dream.
link |
01:15:08.240
He was filming, gosh, what was the movie?
link |
01:15:12.240
I don't recall it.
link |
01:15:13.240
I should be shot because I'm from Liverpool myself.
link |
01:15:16.240
But he was on Wimpoll Street in London and filming
link |
01:15:21.240
and he came up with that song, the melody in his sleep
link |
01:15:26.240
not to be outdone by the Beatles
link |
01:15:28.240
and by the way, Let It Be also came from a dream
link |
01:15:33.240
that McCartney had.
link |
01:15:34.240
People usually give it, you know, religious overtones.
link |
01:15:37.240
You know, Mother Mary comes to me speaking words of wisdom,
link |
01:15:41.240
Let It Be.
link |
01:15:42.240
If you've ever asked who Mother Mary is,
link |
01:15:45.240
it's not, you know, the biblical content.
link |
01:15:49.240
It's his mother.
link |
01:15:51.240
It's Mary McCartney.
link |
01:15:53.240
And she came to him in a dream and gifted him the song.
link |
01:15:57.240
But the best story I've heard is not to be outdone
link |
01:16:02.240
by the Beatles, the Stones.
link |
01:16:04.240
Keith Richards, who I think once was suggested it.
link |
01:16:10.240
Who was it?
link |
01:16:11.240
It was a comedian who was saying that in an interview
link |
01:16:15.240
with Rolling Stone, Keith Richards suggested or inferred
link |
01:16:18.240
that young kids should not do drugs.
link |
01:16:20.240
And they said, well, look, young kids can't do drugs
link |
01:16:26.240
because you've done all of the drugs.
link |
01:16:29.240
But Keith Richards described he would always go to bed
link |
01:16:34.240
with his guitar and a tape recorder.
link |
01:16:39.240
And then probably he would have a whole set of other things
link |
01:16:43.240
in the bed with him and who knows how many other people.
link |
01:16:45.240
But anyway, and then he said in his autobiography,
link |
01:16:49.240
and I'm paraphrasing here, but one morning I woke up
link |
01:16:53.240
and I realized that the tape had recorded all the way to the end.
link |
01:16:58.240
So I rewound the tape and I hit play.
link |
01:17:02.240
And there in some kind of ghostly form
link |
01:17:05.240
were the opening chords to satisfaction.
link |
01:17:08.240
The most famous successful Rolling Stone song of all time.
link |
01:17:12.240
Yeah.
link |
01:17:13.240
Followed by then 43 minutes of snoring.
link |
01:17:16.240
That's awesome.
link |
01:17:18.240
But that riff came to him when one of the most famous riffs
link |
01:17:21.240
in all of rock and roll came to him
link |
01:17:23.240
by way of a dream inspired insight.
link |
01:17:25.240
So I think there is too many of those anecdotes.
link |
01:17:30.240
And we've now got the science.
link |
01:17:31.240
I don't rely on anecdotes as science.
link |
01:17:33.240
We've now done the studies in the laboratory
link |
01:17:35.240
and we can reliably demonstrate that sleep inspires creativity
link |
01:17:39.240
inspires problem solving capacity.
link |
01:17:41.240
Well, the interesting thing is is it possible
link |
01:17:43.240
to some of the ideas that you talk about
link |
01:17:45.240
to turn them into a protocol that could be practiced rigorously.
link |
01:17:48.240
So what Jim Keller espouses is saying
link |
01:17:53.240
not just the fact that sleep helps you increase the creativity
link |
01:17:58.240
but turn it into a process.
link |
01:18:00.240
Like literally, like don't do it accidentally.
link |
01:18:03.240
You know, like an athlete does certain things
link |
01:18:08.240
to optimize their performance.
link |
01:18:10.240
They have a training routine.
link |
01:18:11.240
They have a regimen of cycling and sprints
link |
01:18:16.240
and long distance stuff in the same way
link |
01:18:19.240
thinking about your job as an idea generator
link |
01:18:23.240
in the engineering space is like,
link |
01:18:25.240
this is good for my performance.
link |
01:18:27.240
So like for an hour before bed,
link |
01:18:29.240
think through a problem like every night
link |
01:18:31.240
and then use sleep to work through that problem.
link |
01:18:36.240
I mean, these the first person that I heard
link |
01:18:38.240
like of the people I really respect
link |
01:18:40.240
that do like what I do,
link |
01:18:42.240
which is like programming engineering type work
link |
01:18:45.240
like using sleep, not accidentally, but with a purpose
link |
01:18:50.240
like using sleep.
link |
01:18:52.240
You know, that's just basically the difference
link |
01:18:54.240
between, as you said, a passive approach to it
link |
01:18:57.240
versus, you know, an active deterministic
link |
01:19:01.240
or hope for a deterministic approach to it.
link |
01:19:03.240
In other words, that you are actually trying to harness
link |
01:19:08.240
the power of sleep in a deliberate way
link |
01:19:11.240
rather than an unthoughtful way.
link |
01:19:13.240
I still think that, you know, mother nature through it,
link |
01:19:17.240
you know, the 3.6 million years of evolution
link |
01:19:19.240
has probably got it mostly figured out
link |
01:19:22.240
in terms of what information should be uploaded
link |
01:19:25.240
at night and worked through.
link |
01:19:27.240
I think our algorithm is probably pretty good at this stage.
link |
01:19:31.240
It's not to suggest though that, you know,
link |
01:19:33.240
we can't try to tweak it and nudge it.
link |
01:19:35.240
You know, it's a very light hand on the tiller
link |
01:19:37.240
is what he's doing.
link |
01:19:39.240
I don't think there's anything wrong with that.
link |
01:19:41.240
You know, just like, for example, for me,
link |
01:19:43.240
fasting has improved my ability to focus deeply
link |
01:19:47.240
and productivity significantly.
link |
01:19:49.240
And in that same way, you know, it's possible
link |
01:19:53.240
that playing with these ideas of thinking before bed
link |
01:19:56.240
or some hours before bed or some,
link |
01:19:58.240
playing with different protocols
link |
01:20:00.240
will have a significant leap over
link |
01:20:02.240
what mother nature naturally does.
link |
01:20:04.240
So if you let your body do what it naturally does,
link |
01:20:06.240
you may not achieve the same level of performance.
link |
01:20:09.240
Because mother nature has not designed us
link |
01:20:13.240
to think deeply about chip design
link |
01:20:16.240
or programming artificial intelligence systems.
link |
01:20:20.240
Well, she's gifted us the architecture
link |
01:20:23.240
and the capacity to do that.
link |
01:20:25.240
What we do with that is, you know,
link |
01:20:28.240
is what life's experience dictates.
link |
01:20:31.240
She gives us the blueprint to do many.
link |
01:20:34.240
Well, if I were to sort of introspect
link |
01:20:37.240
and self analyze what mother nature wants me to do,
link |
01:20:40.240
I think, given my current lifestyle,
link |
01:20:42.240
that I have food in the fridge and a bed to sleep on,
link |
01:20:47.240
I think what mother nature wants me to do is to be lazy.
link |
01:20:50.240
And so I think I'm actually resisting mother nature.
link |
01:20:55.240
And because so many of my needs are satisfied.
link |
01:20:59.240
And so I have to resist some of the natural forces
link |
01:21:04.240
of the body and the mind when I do some of the things I do.
link |
01:21:07.240
So there's that dance, you know,
link |
01:21:10.240
like I've been thinking about doing a startup
link |
01:21:12.240
and that's obviously going against everything
link |
01:21:15.240
that my body and mind are telling me to do.
link |
01:21:18.240
Because it's going to be basically suffering.
link |
01:21:21.240
But the only reason I want...
link |
01:21:23.240
As you know it, we'll be over.
link |
01:21:26.240
Yes.
link |
01:21:28.240
But nevertheless, there's some kind of inner drive
link |
01:21:31.240
that wants me to do it.
link |
01:21:32.240
When you start to ask a question,
link |
01:21:34.240
well, how do you optimize the things you can't optimize,
link |
01:21:36.240
like sleep, like diet,
link |
01:21:38.240
like the people that you surround yourself with,
link |
01:21:40.240
in order to maximize happiness and performance
link |
01:21:43.240
and all those kinds of things,
link |
01:21:45.240
without also over optimizing.
link |
01:21:47.240
And that's such an interesting idea from an engineer.
link |
01:21:53.240
So as you may know,
link |
01:21:55.240
you don't often get those kinds of ideas from engineers.
link |
01:21:59.240
Engineers usually just don't read books about sleeping.
link |
01:22:03.240
They're usually like...
link |
01:22:05.240
They're not the healthiest of people.
link |
01:22:10.240
I think that's changing over time,
link |
01:22:13.240
especially Silicon Valley,
link |
01:22:14.240
especially the tech sector.
link |
01:22:15.240
People are starting to understand what's a healthy lifestyle.
link |
01:22:18.240
But usually they're kind of on the insane side,
link |
01:22:21.240
especially programmers.
link |
01:22:22.240
But it's nice to hear somebody like that use sleep
link |
01:22:27.240
and use some of the things that you talk about strategically
link |
01:22:30.240
on purpose.
link |
01:22:32.240
You know, to that idea of not just trying to use
link |
01:22:36.240
what Mother Nature gave,
link |
01:22:38.240
but seeing if you can do something more or different.
link |
01:22:45.240
In a conservative mindset,
link |
01:22:48.240
I would then pose the question at what cost?
link |
01:22:52.240
Because when you do something perhaps
link |
01:22:55.240
that deviates from the typical preprogrammed Mother Nature's program,
link |
01:23:03.240
I suspect it usually comes at the cost of something else.
link |
01:23:07.240
So maybe he is able to direct and focus his sleeping cognition
link |
01:23:14.240
on those particular topics
link |
01:23:16.240
that will gain him better problematic resolution the next day
link |
01:23:20.240
when he wakes up.
link |
01:23:21.240
The question is, though,
link |
01:23:23.240
at what cost of the other things that didn't make it
link |
01:23:26.240
onto the menu of the finger buffet of sleep that night?
link |
01:23:31.240
And is it that you don't process the emotional difficulties
link |
01:23:36.240
or events and therefore you are less emotionally resolved
link |
01:23:40.240
the next day,
link |
01:23:41.240
but you are more problem resolved the following day?
link |
01:23:45.240
And so I always try to think,
link |
01:23:47.240
and I truly don't want to sound puritanical either about sleep.
link |
01:23:52.240
And I think I've come off that way many a times,
link |
01:23:55.240
especially when I started out in the public.
link |
01:23:58.240
The tone of the book in some ways,
link |
01:24:01.240
I look back and think, could I have been a little softer?
link |
01:24:05.240
And the reason was I was that way back in,
link |
01:24:10.240
when I started writing the book,
link |
01:24:11.240
which was probably something like 2014 or 15,
link |
01:24:16.240
sleep was the neglected stepsister
link |
01:24:18.240
in the health conversation of the day.
link |
01:24:21.240
And I was just so sad to see the amount of suffering
link |
01:24:25.240
and disease and sickness that was caused by insufficient sleep.
link |
01:24:29.240
And for years before I'd been doing public speaking
link |
01:24:33.240
and I'd tell people about the great things
link |
01:24:35.240
that happen when you get sleep,
link |
01:24:36.240
people would say, that's fascinating.
link |
01:24:38.240
And then they would go back
link |
01:24:39.240
and keep doing the same thing about not sleeping enough.
link |
01:24:42.240
And then I realized,
link |
01:24:43.240
you can't really speak about the good things that happen.
link |
01:24:45.240
It's like the news, what bleeds leads.
link |
01:24:47.240
And if you speak about the alarmingly bad things that happen,
link |
01:24:50.240
people tend to have a behavioral change.
link |
01:24:52.240
And so the book as a consequence,
link |
01:24:55.240
I think probably came out a little bit on the strong side
link |
01:24:59.240
of trying to convince people.
link |
01:25:03.240
You were trying to help a lot of people
link |
01:25:05.240
and that's a powerful way to help a lot of people.
link |
01:25:07.240
I was genuinely trying to help people,
link |
01:25:09.240
but certainly for some people for whom sleep does not come easy,
link |
01:25:13.240
then it was probably a tricky book to read too.
link |
01:25:17.240
And I think I feel more sensitive to those people now
link |
01:25:20.240
and empathetically connected to them.
link |
01:25:23.240
So I think, again, the point was simply that
link |
01:25:27.240
I don't mean to sound too puritanical in all of this.
link |
01:25:32.240
And the same way with caffeine and coffee.
link |
01:25:36.240
I am just a scientist
link |
01:25:38.240
and I am not here to tell anyone how to live their life.
link |
01:25:41.240
That is not my job at all.
link |
01:25:43.240
And life is to be lived to a degree.
link |
01:25:47.240
And life is to be lived if you want to do a startup.
link |
01:25:51.240
All I want to do is empower people with the understanding
link |
01:25:55.240
of the science of sleep.
link |
01:25:57.240
And then you can make an informed choice
link |
01:25:59.240
as to how you want to live your life.
link |
01:26:01.240
And I often no judgment on how anyone wishes to live their life.
link |
01:26:05.240
I just want to try and see if the information
link |
01:26:08.240
that I have about sleep would alternatively change
link |
01:26:12.240
the way you would think about your life decisions.
link |
01:26:14.240
And if it doesn't, no problem.
link |
01:26:16.240
And if it does, I hope it's been of use.
link |
01:26:19.240
Well, maybe this is me trying to justify my lifestyle to you.
link |
01:26:23.240
But Dr. Seuss said,
link |
01:26:27.240
you know you're in love when you can't fall asleep
link |
01:26:29.240
because reality is finally better than your dreams.
link |
01:26:33.240
I love that quote too.
link |
01:26:35.240
Okay.
link |
01:26:38.240
My sleeping schedule is complicated.
link |
01:26:41.240
And it has to do primarily with the fact that I love
link |
01:26:47.240
basically everything that I do.
link |
01:26:49.240
And that love takes a form that may not appear
link |
01:26:53.240
to be love from the external observer perspective
link |
01:26:56.240
because it often includes struggle.
link |
01:26:58.240
It often includes something that looks like stress
link |
01:27:02.240
even though it's not stress.
link |
01:27:03.240
It's like this excitement.
link |
01:27:05.240
It's this turmoil and chaos of passion
link |
01:27:09.240
of struggling with a problem, of being sad and down
link |
01:27:14.240
to the point even depressed of how difficult the problem is,
link |
01:27:18.240
the disappointment that the last few weeks and months
link |
01:27:21.240
have been a failure and self doubt, all that mix.
link |
01:27:25.240
But I love it.
link |
01:27:27.240
And a part of that is sometimes staying up all night
link |
01:27:30.240
working on a thing I'm really passionate about.
link |
01:27:33.240
And that means sleep schedules that are just like,
link |
01:27:37.240
you know, sometimes sleeping during the day,
link |
01:27:40.240
sometimes very often sleeping very little
link |
01:27:43.240
but taking naps that are like an hour or two hours and so on.
link |
01:27:46.240
That kind of weird chaos.
link |
01:27:48.240
And now I'll also try to give myself back up.
link |
01:27:54.240
I was trying to like research yesterday
link |
01:27:56.240
is anybody else productive while like this.
link |
01:27:59.240
And there's of course a lot of anecdotal evidence
link |
01:28:02.240
and some of it could be just narratives
link |
01:28:05.240
that people have told to the public
link |
01:28:07.240
when in reality they sleep way more.
link |
01:28:09.240
But there's a bunch of people that, you know,
link |
01:28:13.240
are famous for not sleeping much.
link |
01:28:16.240
So on the topic of naps,
link |
01:28:19.240
I read this a long time ago and I checked
link |
01:28:22.240
is Churchill was big on big naps.
link |
01:28:25.240
And is actually just reading more about
link |
01:28:28.240
Winston Churchill's sleep schedule is very much like mine.
link |
01:28:32.240
So I basically want to give myself the opportunity
link |
01:28:36.240
to at night to stay up all night if I want to.
link |
01:28:40.240
And a good nap is a big part of that in the late evening.
link |
01:28:44.240
Like I'll often, that's just destroy social life completely.
link |
01:28:47.240
But I'll often take a nap in the late afternoon or the evening.
link |
01:28:52.240
And that sets me if I want to stay up all night.
link |
01:28:55.240
And things like that, like I read that Nicola Tesla
link |
01:29:00.240
slept only two hours a night, Edison the same three hours.
link |
01:29:04.240
But he actually did the polyphasic sleep
link |
01:29:07.240
like where's just a bunch of naps.
link |
01:29:09.240
What can you say about this madness of love and passion
link |
01:29:16.240
of loving everything you do
link |
01:29:18.240
and the chaos of sleep that might result in?
link |
01:29:22.240
I love the Seuss quote.
link |
01:29:25.240
And I've had that experience too.
link |
01:29:28.240
Like you, I adore what I do.
link |
01:29:32.240
You know, if someone gave you enough money
link |
01:29:37.240
to live the rest of your life, you know,
link |
01:29:39.240
I've got a roof above my head, rice and beans on the table.
link |
01:29:42.240
And they said, you don't have to work anymore.
link |
01:29:44.240
I would do nothing different.
link |
01:29:46.240
I would do exactly, you know, the sounds a little crass.
link |
01:29:51.240
And I hope it doesn't sound this way.
link |
01:29:53.240
But being a scientist is not what I do.
link |
01:30:00.240
It's who I am.
link |
01:30:02.240
And when that's the case, sleep, working out,
link |
01:30:08.240
sharing and eating are the things that I do
link |
01:30:12.240
in between my love affair with sleep.
link |
01:30:16.240
Yeah.
link |
01:30:17.240
I fell for sleep like a blind roofer.
link |
01:30:19.240
And it was a love affair that started 20 years ago
link |
01:30:28.240
and I remain utterly besotted today.
link |
01:30:33.240
It's the most beguiling thing in the world to me.
link |
01:30:37.240
And I could easily, and I have, you know,
link |
01:30:39.240
it's kept me up at night.
link |
01:30:41.240
When my mind is fizzing with experimental ideas
link |
01:30:44.240
or I think I've got a new hypothesis or theory,
link |
01:30:47.240
I will struggle with sleep.
link |
01:30:49.240
I really will.
link |
01:30:50.240
It doesn't come easy to me
link |
01:30:52.240
because my mind is just so on fire with those ideas.
link |
01:30:56.240
So I understand the struggle.
link |
01:31:01.240
But, you know, I couldn't advocate from a scientific perspective
link |
01:31:07.240
the schedule because the science just doesn't, you know,
link |
01:31:11.240
I would feel as though I'm doing you a disservice to say,
link |
01:31:15.240
it's okay.
link |
01:31:17.240
You know, that won't come with some blast radius,
link |
01:31:20.240
some, you know, health consequences.
link |
01:31:22.240
You know, you can add Margaret Thatcher and Ronald Reagan
link |
01:31:25.240
to that list too.
link |
01:31:26.240
Both of them were very, you know,
link |
01:31:29.240
proud chest beaters of how little sleep that they get.
link |
01:31:32.240
Thatcher said four hours, Reagan, something similar.
link |
01:31:35.240
You know, and I, knowing the links that we now know
link |
01:31:38.240
between sleep and Alzheimer's disease,
link |
01:31:40.240
I've often wondered whether it was coincidental then
link |
01:31:42.240
that both of them died of the terrible disease of Alzheimer's,
link |
01:31:46.240
meaning, you know, maybe it doesn't get you by way of,
link |
01:31:49.240
you know, being popped out of the gene pool in a car accident
link |
01:31:51.240
because you had a microsleep at the wheel at age 32,
link |
01:31:54.240
or it doesn't get you at 42 with, you know, heart attack
link |
01:31:59.240
or even 52 with cancer or a stroke.
link |
01:32:03.240
Maybe it gets you in your 70s.
link |
01:32:05.240
I think the elastic band of sleep deprivation
link |
01:32:07.240
can stretch only so far before it snaps.
link |
01:32:10.240
And it ultimately seems to snap.
link |
01:32:13.240
You know, Nikol Tesla, I think he,
link |
01:32:17.240
I think he died of a coronary thrombosis, I believe.
link |
01:32:22.240
And there was a wonderful study done out of Harvard
link |
01:32:25.240
where they took a group of people who had no signs
link |
01:32:27.240
of cardiovascular disease.
link |
01:32:29.240
And what they found is that when they tracked them
link |
01:32:32.240
for years afterwards, they were completely healthy
link |
01:32:36.240
to begin with.
link |
01:32:37.240
Those people who were getting less than six hours of sleep
link |
01:32:40.240
ended up having a 300% increased risk
link |
01:32:43.240
of developing calcification of the coronary artery,
link |
01:32:46.240
which is the major sort of corridor of life for your heart.
link |
01:32:51.240
When someone says, you know, he died of a massive coronary,
link |
01:32:54.240
it's because of a blockade of the coronary artery.
link |
01:32:58.240
You know, and Tesla, you know, passed away
link |
01:33:00.240
from a coronary thrombosis.
link |
01:33:03.240
We also know that insufficient sleep is linked
link |
01:33:05.240
to numerous mental health issues.
link |
01:33:07.240
We know that Churchill had a wicked battle with depression.
link |
01:33:11.240
Gosh, my goodness, he used to call it black dog
link |
01:33:13.240
that would come and visit him.
link |
01:33:15.240
And I think many of his paintings, he was exquisite painter,
link |
01:33:18.240
but some of them would depict his darkness
link |
01:33:20.240
with depression as well.
link |
01:33:24.240
You know, Edison is interesting.
link |
01:33:26.240
People have argued that he would short sleep
link |
01:33:28.240
and he didn't put much value in sleep,
link |
01:33:30.240
whether or not that's true.
link |
01:33:31.240
We don't know.
link |
01:33:32.240
But he was a habitual napper, you're right, during the day.
link |
01:33:34.240
He had some great pictures of him on his inventor's bench
link |
01:33:36.240
taking a nap.
link |
01:33:37.240
And in fact, I believe he set up nap cots around his house
link |
01:33:40.240
so he could nap.
link |
01:33:42.240
But what we also know is that he, again,
link |
01:33:44.240
coming out of Harvard just a couple of months ago,
link |
01:33:47.240
demonstrated very clearly that polyphasic sleep
link |
01:33:50.240
is associated with worse physical outcomes,
link |
01:33:52.240
worse cognitive outcomes,
link |
01:33:54.240
and especially worse mood outcomes.
link |
01:33:57.240
So from that sense, you know, sleeping like a baby
link |
01:33:59.240
is not perfect for adults.
link |
01:34:02.240
There's a fascinating dance here
link |
01:34:05.240
of the mean and the extreme,
link |
01:34:09.240
like the average and the high performers.
link |
01:34:13.240
So I, this gets to like the meaning of life
link |
01:34:20.240
kind of discussion, but let's go then.
link |
01:34:24.240
And also happiness.
link |
01:34:26.240
So when studying sleep and when studying anything,
link |
01:34:29.240
like diet and exercise,
link |
01:34:31.240
I think you have to really get a lot more data
link |
01:34:35.240
about individuals to make a conclusive statement.
link |
01:34:41.240
That's when people talk about, like,
link |
01:34:43.240
is meat, red meat good for your bad for you, right?
link |
01:34:46.240
It's just so often correlated with other life decisions
link |
01:34:50.240
when you choose to eat meat or not.
link |
01:34:52.240
My sense is that whatever life decisions you make,
link |
01:34:59.240
if they reduce stress and lead to happiness,
link |
01:35:04.240
that's also going to be a big boost.
link |
01:35:06.240
They need to be integrated into the plots in the science, right?
link |
01:35:09.240
So I'll give you an example of somebody
link |
01:35:12.240
who is unarguably seen as unhealthy.
link |
01:35:16.240
My friend, Mr. David Goggins.
link |
01:35:20.240
So he's clearly obviously almost on purpose destroying his body.
link |
01:35:26.240
And to say that he's doing the wrong thing
link |
01:35:30.240
or the unhealthy thing feels like, feels wrong.
link |
01:35:36.240
But I'm not sure exactly in which way he feels wrong.
link |
01:35:41.240
One of the things I'm bothered by,
link |
01:35:43.240
and again, I apologize for the therapy sessions,
link |
01:35:47.240
a framework of this, but I'm bothered by the fact
link |
01:35:53.240
that a lot of people tell me or David
link |
01:35:58.240
that they're doing things wrong.
link |
01:36:02.240
A lot of people in my life when they see me not sleep,
link |
01:36:06.240
they'll tell me to sleep more.
link |
01:36:09.240
Now, they're correct,
link |
01:36:11.240
but one fundamental aspect that I'd like to complain about
link |
01:36:16.240
is not enough people, almost nobody,
link |
01:36:20.240
especially people that care for me,
link |
01:36:22.240
will come to me and say,
link |
01:36:25.240
you have a dream, work harder.
link |
01:36:30.240
Like, it's like the healthy thing
link |
01:36:37.240
should be a component of a life well lived,
link |
01:36:41.240
but not everything.
link |
01:36:44.240
And I don't know what to do with that
link |
01:36:46.240
because you certainly don't want to espouse.
link |
01:36:48.240
And just like you said, when you were working in your book,
link |
01:36:51.240
there is a belief that you don't sleep
link |
01:36:54.240
as a secondary citizen in the full spectrum
link |
01:36:57.240
of what's a healthy life,
link |
01:36:59.240
but at the same time, I'm bothered by in Silicon Valley
link |
01:37:02.240
and all these kinds of work environments
link |
01:37:05.240
that I get to work with with engineers
link |
01:37:07.240
is there's, to me, too much focus on work life balance.
link |
01:37:13.240
What that usually starts meaning is like,
link |
01:37:16.240
yeah, of course, it's good to have a social life,
link |
01:37:18.240
it's good to have a family, it's good to eat well
link |
01:37:22.240
and sleep well, but we should also discover our passion.
link |
01:37:25.240
We should also give our chance to give ourselves
link |
01:37:29.240
a chance to work our ass off towards a dream
link |
01:37:33.240
and make mistakes and take big risks
link |
01:37:36.240
that in the short term seem to sacrifice health.
link |
01:37:39.240
And I think to come back to how you started
link |
01:37:42.240
about David Goggins, who I've never met,
link |
01:37:45.240
but who I admire incredibly
link |
01:37:48.240
and have an immense reverence for the man,
link |
01:37:51.240
you said two things.
link |
01:37:53.240
Is it wrong to do those things to yourself?
link |
01:37:59.240
And is it unhealthy to do those things to yourself?
link |
01:38:03.240
I disagree with the former and I agree with the latter.
link |
01:38:07.240
So from a health biological medicine perspective,
link |
01:38:11.240
sleeping in the way that you've described
link |
01:38:14.240
or that other people may be sleeping
link |
01:38:16.240
in terms of insufficient amounts.
link |
01:38:19.240
Now, to your point too about individual differences,
link |
01:38:24.240
usually when I see a bar graph and a mean,
link |
01:38:27.240
I usually say, show me your variance.
link |
01:38:30.240
I want to see your variance.
link |
01:38:32.240
In other words, show me the distribution of that effect.
link |
01:38:35.240
How many people were below the mean?
link |
01:38:37.240
Is it all tightly clustered around this one thing
link |
01:38:40.240
so it's a very robust effect?
link |
01:38:42.240
I'm a huge fan of effect where for some people,
link |
01:38:45.240
there was no effect at all in other people.
link |
01:38:47.240
There was a whopping effect in everything in between.
link |
01:38:49.240
So I don't discount into individual variability.
link |
01:38:54.240
But, and I will come back to those two points about,
link |
01:38:57.240
is it wrong and is it unhealthy in just a second?
link |
01:39:00.240
When it comes to sleep, we have found huge amounts
link |
01:39:03.240
of interindividual differences in your response
link |
01:39:06.240
to a lack of sleep.
link |
01:39:08.240
But one of the fascinating things,
link |
01:39:10.240
that I take you on, we're going to measure your attention,
link |
01:39:13.240
your emotion, your mood, your blood pressure,
link |
01:39:16.240
your blood sugar glucose regulation,
link |
01:39:19.240
your autonomic nervous system,
link |
01:39:21.240
and your different gene expression.
link |
01:39:23.240
Let's say I'm just going to measure a whole kaleidoscope
link |
01:39:26.240
of different outcomes, brain and body.
link |
01:39:28.240
And I find that on our measure of cognition
link |
01:39:31.240
on your attentional ability to focus,
link |
01:39:33.240
you are very resilient.
link |
01:39:35.240
You just don't show any impermanence at all,
link |
01:39:37.240
even after being awake for 36 hours straight.
link |
01:39:40.240
Does that mean that you are resilient
link |
01:39:42.240
in all of those other domains as well?
link |
01:39:44.240
The answer is no, you're not.
link |
01:39:46.240
So you can be resilient in one,
link |
01:39:48.240
but very vulnerable in another.
link |
01:39:51.240
And we've not found anyone
link |
01:39:54.240
who isn't at least vulnerable in one of those domains,
link |
01:39:58.240
meaning that it's somewhat safe to say
link |
01:40:01.240
that not getting sufficient sleep
link |
01:40:03.240
will lead to some kind of impairment
link |
01:40:06.240
in anyone given individual.
link |
01:40:08.240
It may not be the same impairment,
link |
01:40:10.240
but it's likely to be an impairment.
link |
01:40:12.240
But to come back to the question,
link |
01:40:14.240
I think it's wrong to tell anyone
link |
01:40:16.240
that it's wrong to do what they're doing,
link |
01:40:19.240
even if they are compromising their sleep,
link |
01:40:21.240
even if they're compromising their mental health.
link |
01:40:24.240
You know, as long as they're not hurting anyone else,
link |
01:40:28.240
then I think the answer is that's that person's choice.
link |
01:40:32.240
Yeah, but that's that person's life.
link |
01:40:34.240
I'd like to push back further.
link |
01:40:36.240
So, see, the way you kind of said it,
link |
01:40:39.240
yes, you're absolutely right.
link |
01:40:41.240
But I would like to say a stronger statement,
link |
01:40:45.240
which is you should let go of that judgment
link |
01:40:49.240
of somebody is wrong
link |
01:40:51.240
and allow yourself to be inspired
link |
01:40:53.240
by the great heights they have reached.
link |
01:40:55.240
So take yourself out of the seat
link |
01:40:58.240
of being a judge of what is healthy and not,
link |
01:41:01.240
and appreciate the greatness of a particular human.
link |
01:41:05.240
You watch the Olympics,
link |
01:41:07.240
the kind of things that some athletes do to reach
link |
01:41:10.240
the very heights.
link |
01:41:12.240
The Olympics are taking years off of their life.
link |
01:41:15.240
They suffer depression after the Olympics often.
link |
01:41:18.240
The physiology is disastrous in everything.
link |
01:41:21.240
Their personal life, their psychology, their physiology,
link |
01:41:26.240
everything, it's a giant mess.
link |
01:41:29.240
The question is about life.
link |
01:41:32.240
Healthy now means longevity, quality of life
link |
01:41:40.240
over a prolonged period of time,
link |
01:41:42.240
optimal performance over a prolonged period of time.
link |
01:41:46.240
But to me, beauty is reaching great heights.
link |
01:41:52.240
And there's a dance there
link |
01:41:54.240
that sometimes reaching great heights
link |
01:41:56.240
requires sacrifice of health
link |
01:41:58.240
and not like a calculation
link |
01:42:01.240
where you sat down on a sheet of paper and say,
link |
01:42:03.240
I'm going to take seven years off my life
link |
01:42:05.240
for an Olympic gold medal.
link |
01:42:07.240
No, it requires more chaotic journey
link |
01:42:10.240
that doesn't do that kind of calculus.
link |
01:42:13.240
And I just want to kind of speak to the,
link |
01:42:15.240
in the culture that struggles of what is healthy and not,
link |
01:42:19.240
we want to be able to speak to what is healthy
link |
01:42:22.240
and at the same time be inspired by the great heights
link |
01:42:26.240
that humans reach no matter how healthy
link |
01:42:29.240
or unhealthy they live.
link |
01:42:32.240
Yeah, I agree with that.
link |
01:42:34.240
I think if that's a flag you're hoisting,
link |
01:42:35.240
I will definitely salute it because it really depends.
link |
01:42:38.240
What are you trying to optimize for in your life?
link |
01:42:41.240
And if you are, I think the only danger
link |
01:42:44.240
potentially with that mindset is that
link |
01:42:47.240
if you look at many of the studies of old age
link |
01:42:51.240
and end of life,
link |
01:42:53.240
most people say, I never look back on my life
link |
01:42:57.240
and wish I worked harder.
link |
01:43:01.240
I wish instead I'd spent more time
link |
01:43:04.240
with family, friends, and engaged in that aspect.
link |
01:43:08.240
Now, I'm not saying though, coming back to your point
link |
01:43:11.240
that that is the standard rubric for everyone.
link |
01:43:13.240
I don't believe it is too.
link |
01:43:15.240
And there are many things that you and I
link |
01:43:17.240
are both benefiting from today,
link |
01:43:19.240
even in the field of medicine,
link |
01:43:22.240
where people have sacrificed their own longevity
link |
01:43:26.240
for the quest of solving a particular medical problem.
link |
01:43:30.240
And they died quicker because of their commitment
link |
01:43:37.240
because they wished to try and solve that problem
link |
01:43:40.240
in their pursuit of greatness scientifically.
link |
01:43:42.240
And I now benefit.
link |
01:43:44.240
Am I grateful that they did that?
link |
01:43:46.240
Incredibly grateful.
link |
01:43:48.240
A simpler demonstration is this.
link |
01:43:51.240
If tonight at 4 a.m. in the morning,
link |
01:43:54.240
I have a ruptured appendix.
link |
01:43:57.240
I have an appendicitis.
link |
01:43:59.240
I am incredibly grateful that there is an emergency team
link |
01:44:04.240
that will take me to the hospital at 4 a.m. in the morning.
link |
01:44:07.240
They are awake.
link |
01:44:08.240
They're not sleeping.
link |
01:44:09.240
And they save my life.
link |
01:44:12.240
And that's part of what their life's mission and quest is.
link |
01:44:17.240
And they saved another's life by, in some ways,
link |
01:44:21.240
shaving a little of their own off.
link |
01:44:24.240
So I have no umbrage with that mentality at all.
link |
01:44:29.240
I think you just have to be very clear
link |
01:44:31.240
about what you're optimizing for.
link |
01:44:34.240
And my worry is that most people fall into the rat race.
link |
01:44:39.240
And they never actually ask the question,
link |
01:44:41.240
why am I doing this?
link |
01:44:43.240
If you're just working 9 to 5,
link |
01:44:47.240
and you allow that 9 to 5 to stretch into much longer,
link |
01:44:51.240
but it's nevertheless a job that's kind of like,
link |
01:44:54.240
wears you down, that's one thing.
link |
01:44:56.240
Another thing is when it's a dream.
link |
01:45:02.240
It's a life mission to accomplish.
link |
01:45:04.240
And for that, I think as long as you know
link |
01:45:08.240
what it is that you could be doing to yourself,
link |
01:45:11.240
you are comfortable and AOK with that.
link |
01:45:14.240
I have no problem with that at all.
link |
01:45:17.240
Again, as I said, as a scientist,
link |
01:45:20.240
I cannot, should not and will not tell anyone
link |
01:45:23.240
what they should do with their life.
link |
01:45:25.240
All I want you to be able to do is say,
link |
01:45:27.240
okay, now I understand more about the,
link |
01:45:31.240
previously these were the known unknowns
link |
01:45:35.240
and these were the unknown unknowns.
link |
01:45:38.240
And now I am slightly more cognizant.
link |
01:45:41.240
I have more knowns than I had before
link |
01:45:46.240
regarding my sleep and my health.
link |
01:45:48.240
Knowing that information, do I still choose
link |
01:45:51.240
to make this decision?
link |
01:45:53.240
And if that's what I offered,
link |
01:45:57.240
then I think I've done my job.
link |
01:45:59.240
That's all I want to offer is just added information
link |
01:46:02.240
into the decision algorithm.
link |
01:46:04.240
And what you end up choosing as an output of that algorithm
link |
01:46:09.240
has nothing to do with me.
link |
01:46:11.240
It's not my business and I will never judge anyone for it.
link |
01:46:14.240
And as I said, I'm immensely grateful
link |
01:46:16.240
for people who have sacrificed much in their lives
link |
01:46:19.240
to give me what I have.
link |
01:46:21.240
So you're saying as long as the sacrifice
link |
01:46:23.240
sort of grounded in knowledge of, you know,
link |
01:46:25.240
what the sacrifice is that sleep is important
link |
01:46:28.240
and all those kinds of things.
link |
01:46:29.240
And that you're comfortable with it.
link |
01:46:30.240
That is, it is your conscious choice
link |
01:46:32.240
rather than feeling as though you're trapped
link |
01:46:34.240
or that you are just, you haven't thought about it.
link |
01:46:38.240
And, you know, you start that job at age 32
link |
01:46:41.240
and then you wake up the next morning and you're 65
link |
01:46:44.240
and you think, where did my life go?
link |
01:46:46.240
What was I doing?
link |
01:46:47.240
That to me, I would feel, I would want to hug you
link |
01:46:49.240
and I would say I'm so, I'm just,
link |
01:46:52.240
and I'm not sounding, I don't want to sound belittling
link |
01:46:54.240
here at all.
link |
01:46:56.240
I would just not wish that for you.
link |
01:46:59.240
I would wish that you could have, you know,
link |
01:47:03.240
thought about what it was that you're doing
link |
01:47:05.240
and not have that regret.
link |
01:47:07.240
Yeah, so I guess this is for you, the listener.
link |
01:47:10.240
I'm coming out of the closet here a little bit.
link |
01:47:12.240
The fact that I enjoy the madness I live in,
link |
01:47:15.240
so please do not criticize me, embrace me.
link |
01:47:18.240
I understand the sacrifices I'm making.
link |
01:47:21.240
I enjoy sleeping on the floor when I'm
link |
01:47:23.240
passionately programming all night
link |
01:47:25.240
and just pass out on the carpet.
link |
01:47:28.240
I love this life, okay?
link |
01:47:30.240
So it's definitely something I think about
link |
01:47:33.240
that there's a balance of strike.
link |
01:47:37.240
I just want you to have as much of it though.
link |
01:47:40.240
Of life.
link |
01:47:44.240
See, quality of life is important.
link |
01:47:49.240
I should have said I want you to have as much
link |
01:47:51.240
high quality life and if high quality of life
link |
01:47:55.240
means I spend five decades on this planet,
link |
01:48:01.240
but yet in that time I am thrilled every day.
link |
01:48:04.240
I'm turned on every day by what I do
link |
01:48:07.240
and I reveled in this thing called my life's work.
link |
01:48:14.240
I think that that is a 50 year journey
link |
01:48:17.240
of absolute delight and fulfillment
link |
01:48:20.240
that you should take.
link |
01:48:24.240
I think about my death all the time.
link |
01:48:26.240
I meditate on death.
link |
01:48:28.240
I'm okay to die today.
link |
01:48:31.240
So to me longevity is not a significant goal.
link |
01:48:37.240
I'm so happy to be alive.
link |
01:48:39.240
I don't even think it would suck to die today.
link |
01:48:43.240
I'm as afraid of it today as I will be in 50 years.
link |
01:48:47.240
I don't want to die as much today as I will in 50 years.
link |
01:48:51.240
There's of course all these experiences I would like to have,
link |
01:48:56.240
but everything is already amazing.
link |
01:48:59.240
It's like that Lego movie.
link |
01:49:01.240
So I don't know.
link |
01:49:03.240
To me I just want to keep doing this.
link |
01:49:06.240
And there's of course things that could affect,
link |
01:49:12.240
like you mentioned dementia and these deterioration
link |
01:49:16.240
of the mind or the body that can significantly affect
link |
01:49:20.240
the quality of life.
link |
01:49:23.240
Do you're aware of that?
link |
01:49:26.240
And that's the price you pay for the entry
link |
01:49:28.240
into this magical kingdom that you are experiencing,
link |
01:49:32.240
which is a lovely thing.
link |
01:49:34.240
I feel privileged too.
link |
01:49:36.240
I can't believe the life that I live.
link |
01:49:38.240
It's incredible.
link |
01:49:41.240
And just like you, I think about mortality a great deal.
link |
01:49:46.240
I think a lot about death,
link |
01:49:48.240
but I don't worry about death.
link |
01:49:52.240
I probably, with the exception of the potential pain
link |
01:49:56.240
that comes before it that some people,
link |
01:49:58.240
many people can suffer, that maybe concerns me.
link |
01:50:02.240
But I actually think about mortality as a tool,
link |
01:50:06.240
as I use it as a lens through which I can then retrospect.
link |
01:50:12.240
And by placing myself at the point of future mortality,
link |
01:50:16.240
I can then use it as a retrospective lens to focus
link |
01:50:21.240
and ask the following question.
link |
01:50:23.240
Is there anything I feel I would regret
link |
01:50:26.240
and therefore change in the life that I currently have now?
link |
01:50:31.240
That's the way I meditate and use mortality as a question,
link |
01:50:36.240
is to try and course correct and focus my life.
link |
01:50:39.240
I worry not about dying,
link |
01:50:42.240
but I like to think about death as a way to prioritize my life.
link |
01:50:47.240
If that makes sense, I don't know if that makes sense.
link |
01:50:49.240
No, it makes total sense to decide how do you want to live today
link |
01:50:55.240
so that in the future you do not regret the way you live today.
link |
01:51:00.240
And to place yourself in the future at your point of mortality
link |
01:51:04.240
is one way to, I think, as an exercise to retrospectively look back
link |
01:51:10.240
and not lose out on informed choices that you could otherwise lose out on
link |
01:51:15.240
if you weren't thinking about mortality.
link |
01:51:18.240
Yeah, it clarifies your thinking.
link |
01:51:22.240
So I mentioned I sleep on the floor, take naps and power naps
link |
01:51:26.240
and just kind of madness.
link |
01:51:28.240
Is there weirdnesses to your own sleep schedule as a scientist
link |
01:51:32.240
that does incredible work, has a lot of things going on,
link |
01:51:38.240
has to lead research, has to write research, has to be a science communicator,
link |
01:51:44.240
also have a social life, all those kinds of things.
link |
01:51:47.240
Is there certain patterns to your own sleep that you regret
link |
01:51:52.240
or you participate in that you find you enjoy?
link |
01:51:59.240
Is there some personal stuff, quirks,
link |
01:52:03.240
or things you're proud of that you do in terms of your sleep schedule?
link |
01:52:07.240
The funny thing about being a sleep researcher is that it doesn't make you immune
link |
01:52:12.240
to the ravages of a difficult night of sleep.
link |
01:52:16.240
And I have battled my own periods of insomnia in my life too.
link |
01:52:24.240
And I think I've been fortunate in ways because I know how sleep works
link |
01:52:28.240
and I know how to combat insomnia.
link |
01:52:30.240
I know how to get it under control.
link |
01:52:32.240
Because insomnia in many ways is a condition where all of a sudden
link |
01:52:38.240
your sleep controls you rather than you control your sleep.
link |
01:52:42.240
Wow, yeah, that's a beautiful way to put it, yeah.
link |
01:52:46.240
And I know when I'm starting to lose control and it's starting to take control.
link |
01:52:54.240
I understand how to regain, but it doesn't happen overnight.
link |
01:53:01.240
It takes a long time.
link |
01:53:03.240
So you've struggled with insomnia in your life?
link |
01:53:06.240
I have not all of my life.
link |
01:53:08.240
I would say I've probably had three or four really severe bouts.
link |
01:53:12.240
And all of them usually triggered by emotional circumstances by stress.
link |
01:53:18.240
Stress that's connected to actual events in life or stress that's unexplainable?
link |
01:53:24.240
All externally triggered.
link |
01:53:26.240
Yeah, it's sort of what we would call reactive stress.
link |
01:53:30.240
And so that's sort of point number one about the idiosyncrasies.
link |
01:53:38.240
The point number two is that when you are having a difficult night of sleep,
link |
01:53:43.240
as a sleep researcher, you basically have become the Woody Allen neurotic of the sleep world.
link |
01:53:49.240
Because at that moment, you know, I'm trying to fall asleep and I'm not.
link |
01:53:54.240
And I'm starting to think, okay, my dorsal lateral prefrontal cortex is not shutting down.
link |
01:53:58.240
Or adrenaline is not ramping down.
link |
01:54:00.240
My sympathetic nervous system is not giving way to my parasitic.
link |
01:54:03.240
At that point, you are dead in the water for the next two hours and nothing is bringing you back.
link |
01:54:08.240
So there is some irony in that too.
link |
01:54:11.240
I would say for myself, though, if there's something I'm not proud of,
link |
01:54:17.240
it has been at times railing against my chronotype.
link |
01:54:23.240
So your chronotype is essentially, are you a morning type evening type or somewhere in between?
link |
01:54:28.240
Yeah.
link |
01:54:29.240
And there were times because society is desperately biased towards the morning types.
link |
01:54:36.240
You know, this notion of the early bird catches the worm.
link |
01:54:40.240
Maybe that's true, but I'll also tell you that the second mouse gets the cheese.
link |
01:54:46.240
Yeah, so I think one of the issues is a good line around, you know,
link |
01:54:52.240
if firstly people don't really understand chronotype,
link |
01:54:55.240
because I'll have some people when I'm sort of out in the public,
link |
01:54:58.240
they'll say, look, I struggled with terrible insomnia and I'll ask them,
link |
01:55:01.240
is it problems falling asleep or staying asleep?
link |
01:55:03.240
And they'll say falling asleep.
link |
01:55:05.240
And then I'll say, look, if you are on a desert island with nothing to wake up for,
link |
01:55:10.240
no responsibilities, what time would you normally go to bed and what time would you wake up?
link |
01:55:14.240
And they would say, I probably like to go to bed about midnight and wake up maybe eight in the morning.
link |
01:55:18.240
Then I'd say, so what time do you now go to bed? And they'd say, well, I've got to be up for work early,
link |
01:55:22.240
so I get into bed at 10.
link |
01:55:24.240
I'd say, well, you don't have insomnia, you have a mismatch between your biological chronotype
link |
01:55:29.240
and your current sleep schedule.
link |
01:55:31.240
And when you align those two, and I was fighting that for some time too,
link |
01:55:35.240
I'm probably mostly right in the middle.
link |
01:55:40.240
I am desperately vanilla, unfortunately, in many aspects of life.
link |
01:55:45.240
But this included, I'm neither a strong morning type nor a strong evening type.
link |
01:55:49.240
So ideally, I'd probably like to go to bed around, you know, 11, 10, 30, 11,
link |
01:55:54.240
probably somewhere between 10, 13, 11, and wake up, you know,
link |
01:55:58.240
I naturally wake up usually most days before my alarm at 7.04.
link |
01:56:04.240
And it's 7.04 because why not be a deosyncratic in terms of sitting up?
link |
01:56:09.240
I love it.
link |
01:56:10.240
And so I... That's kind of awesome. I've never heard about that. That's amazing.
link |
01:56:15.240
I'm going to start doing that now, setting alarms a little bit off the...
link |
01:56:19.240
Yeah, I know. I'm never quite sure why we all...
link |
01:56:22.240
It's a celebration of uniqueness.
link |
01:56:24.240
Yeah, and I am quite the odd snowflake in that sense too.
link |
01:56:28.240
So I would usually then try to force myself because I had that same mentality
link |
01:56:33.240
that if I wasn't up at, you know, 6.30 and in the gym by 7.
link |
01:56:38.240
That there was something wrong with me.
link |
01:56:41.240
And I quickly abandoned that.
link |
01:56:44.240
But if I look back, if there was a shameful act that I have around my sleep,
link |
01:56:47.240
I think it would be that for some years until I really started to get more detailed into sleep.
link |
01:56:52.240
And now I have no shame in telling people that, you know,
link |
01:56:57.240
I will probably usually wake up around 6.45 naturally, sometimes 7.
link |
01:57:03.240
When people are looking at me thinking, you're a sloth, you're lazy.
link |
01:57:08.240
And, you know, I don't finish my daily workout until, you know,
link |
01:57:14.240
I'm not working until probably 9 o clock in the morning.
link |
01:57:17.240
I'm thinking, what are you doing?
link |
01:57:19.240
Now, I will work late into the day.
link |
01:57:22.240
You know, if I could, I would work 16 hours.
link |
01:57:25.240
It's my passion, just like yours.
link |
01:57:29.240
So I don't feel shame around that, but I have changed my mentality around that.
link |
01:57:35.240
It's complicated because I'm probably happiest going to bed
link |
01:57:43.240
if I'm being honest, like at 5 a.m.
link |
01:57:46.240
That's fine. You're just an extreme evening type.
link |
01:57:48.240
But the problem is it's not that I'm ashamed for it.
link |
01:57:54.240
I actually kind of enjoy it because I get to sleep through all the nonsense of, like, the morning.
link |
01:57:59.240
Isn't that a beautiful thing?
link |
01:58:01.240
People are busy with their emails and I just am happy as a cow.
link |
01:58:06.240
And I wake up after all the drama has been resolved.
link |
01:58:09.240
Yeah, and cows are happy and the drama has been resolved.
link |
01:58:12.240
Exactly.
link |
01:58:13.240
But, you know, in society you do, especially, I mean, this is what I think about is,
link |
01:58:18.240
you know, when you work on a larger team, especially with companies,
link |
01:58:22.240
you are, you know, everybody's awake at the same time.
link |
01:58:26.240
So that's definitely been a struggle to try to figure out, just like you said,
link |
01:58:32.240
how to balance that, how to fit into society and yet be optimal for your chronotype.
link |
01:58:38.240
Yeah, to sleep in synchrony with it and harmony.
link |
01:58:42.240
Because normally what we know is that if you fight biology, you'll normally lose.
link |
01:58:48.240
And the way you know you've lost is through disease and sickness.
link |
01:58:52.240
You said you suffered through several bouts of insomnia.
link |
01:58:56.240
Is there, aside from embracing your chronotype,
link |
01:59:02.240
is there a device you can give to overcome insomnia from your own experience?
link |
01:59:07.240
Right now the best method that we have is something called cognitive behavioral therapy for insomnia
link |
01:59:12.240
or CBTI for short.
link |
01:59:14.240
And you work with people who don't know what it is.
link |
01:59:18.240
You work with a therapist for maybe six weeks.
link |
01:59:21.240
And you can do it online, by the way, I recommend probably jumping online.
link |
01:59:24.240
It's just the easiest.
link |
01:59:26.240
And it will change your beliefs, your habits, your behaviors,
link |
01:59:31.240
and your general stress around this thing called sleep.
link |
01:59:34.240
And it is just as effective as sleeping pills in the short term.
link |
01:59:37.240
But what's great is that unlike sleeping pills, when you stop working with your therapist,
link |
01:59:42.240
those benefits last for years later.
link |
01:59:45.240
Whereas when you stop your sleeping pills, you typically have what's called rebound insomnia,
link |
01:59:49.240
where your sleep not only goes back to being as bad as it was before, it's usually even worse.
link |
01:59:54.240
For me, I think I found a number of things effective.
link |
02:00:00.240
The first is that I had to really address what was stressful
link |
02:00:04.240
and try to come up with some degree of meaningful rationality around it.
link |
02:00:11.240
Because I think one of the things that happens,
link |
02:00:13.240
there's something very, talking about conscious states to come all the way back to,
link |
02:00:17.240
gosh, I don't know.
link |
02:00:19.240
I feel like we've only been chatting for like 20 minutes,
link |
02:00:21.240
but you're going to tell me it's been a while.
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02:00:23.240
Yeah, it's been a while.
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02:00:24.240
Okay, I'm desperately, I feel terribly sorry.
link |
02:00:27.240
But let's come back to conscious states where we started.
link |
02:00:32.240
There is something very strange about the night
link |
02:00:36.240
that thoughts and anxieties are not the same as they are in the waking day.
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02:00:43.240
They are worse, they are bigger.
link |
02:00:45.240
And I at least find that I am far more likely to catastrophize and ruminate at night about things,
link |
02:00:58.240
that when I wake up the next day in the broad light of day,
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02:01:01.240
I think it's no one nearer that bad man.
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02:01:04.240
What were you doing?
link |
02:01:05.240
I'm not that bad at all.
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02:01:06.240
So to gain firstly some rational understanding of my emotional state
link |
02:01:12.240
that's causing that insomnia was very helpful.
link |
02:01:15.240
The second thing was to keep regularity,
link |
02:01:18.240
just going to bed at the same time waking up.
link |
02:01:21.240
And here's an unconventional piece of sleep advice.
link |
02:01:25.240
After a bad night of sleep, do nothing.
link |
02:01:31.240
Don't wake up any later.
link |
02:01:34.240
Don't go to bed any earlier.
link |
02:01:37.240
Don't nap during the day.
link |
02:01:39.240
And don't drink any more coffee than you would otherwise.
link |
02:01:42.240
Because if you end up sleeping later into the morning,
link |
02:01:47.240
you're then not going to be tired at your normal time at night.
link |
02:01:51.240
So then you're going to get into bed thinking,
link |
02:01:53.240
well, I had a terrible night of sleep last night and yes, I slept in this morning to try and compensate.
link |
02:01:58.240
But I'm still going to get to bed at my normal time.
link |
02:02:01.240
You get into bed and you haven't been awake for as long as you normally would.
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02:02:05.240
So you're not as sleepy as you normally would be.
link |
02:02:07.240
And so now you sit there lying in bed and it's another bad night.
link |
02:02:11.240
And the same thing is, you know, if you go to bed any earlier,
link |
02:02:15.240
so don't wake up any later, wake up at the same time.
link |
02:02:19.240
Don't go to bed any earlier because then you're just probably your chronotype,
link |
02:02:23.240
your biological rhythm doesn't want you to be asleep.
link |
02:02:26.240
And you think, well, terrible night, I'm going to get into bed at 9 p.m. rather than my standard 10.
link |
02:02:32.240
You're just going to be lying in bed awake for that hour.
link |
02:02:35.240
Naps will take our double edged sword.
link |
02:02:37.240
They can have wonderful benefits and we've done lots of studies on naps for both the brain and the body.
link |
02:02:42.240
But they are a double edged sword in the sense that napping will just take the edge off your sleepiness.
link |
02:02:50.240
It's a little bit like a valve on a pressure cooker.
link |
02:02:52.240
When you nap during the day, you can take some of that healthy sleepiness that you've been building up during the day.
link |
02:02:59.240
And for some people, not all people, but for some people that can then make it harder for them to fall asleep at night
link |
02:03:04.240
and then stay asleep soundly across the night.
link |
02:03:07.240
So the advice would be if you're struggling with sleep at night, don't nap during the day.
link |
02:03:12.240
But if you are not struggling with sleep and you can nap regularly, naps are just fine.
link |
02:03:17.240
And we can play around with optimal durations depending on what you want.
link |
02:03:21.240
Just try not to nap too late into the day because napping late into the day is like snacking before your main meal.
link |
02:03:27.240
It just takes the edge off your sleep hunger as it were.
link |
02:03:30.240
So that's my unconventional second piece of advice regarding insomnia.
link |
02:03:36.240
The third is meditation.
link |
02:03:38.240
I found meditation to be incredibly powerful.
link |
02:03:41.240
I started reading about meditation as I was researching that aspect of the book many years ago.
link |
02:03:49.240
And as a hard nose scientist, I thought this sounds very woo woo.
link |
02:03:53.240
This is sort of we all hold hands and sing come by our and everything's going to be fine with sleep.
link |
02:03:59.240
I read the data and it was compelling.
link |
02:04:02.240
I couldn't ignore it.
link |
02:04:04.240
And I started meditating and that was six years ago and I haven't stopped.
link |
02:04:09.240
And I found meditation before bed incredibly powerful.
link |
02:04:14.240
The meditation app companies were perplexed at this at first, they want people to meditate during the day.
link |
02:04:19.240
But when they looked at their usage statistics, they found that they would have people in the morning meditating.
link |
02:04:24.240
And then there's a huge number of people using the meditation app in the evening.
link |
02:04:28.240
What they were doing was self medicating this.
link |
02:04:31.240
They're insomnia and they finally rather than railing against it, they started to see it as a cash cow.
link |
02:04:38.240
Rightly so.
link |
02:04:39.240
So I found meditation to be helpful having a wind down routine is the other thing that's critical for me.
link |
02:04:45.240
I can't just go from because when my mind is switched on and I think you may be like this too.
link |
02:04:51.240
If I get into bed, that roller decks of thoughts and information and excitement and anxiety and worry is just whirling away.
link |
02:05:02.240
And it's not going to be a good night for me.
link |
02:05:05.240
So I have to find a wind down routine.
link |
02:05:07.240
And that makes sense when you realize what sleep is like.
link |
02:05:10.240
Sleep is not like a light switch.
link |
02:05:13.240
Sleep is much more like trying to land a plane.
link |
02:05:16.240
You know, it takes time to descend down onto the terra firma that we call sound sleep at night.
link |
02:05:22.240
And we have this for kids.
link |
02:05:24.240
You know, I don't have children, but you know, a lot of parents will say, you know, we have to have the bedroom.
link |
02:05:33.240
You're sorry, the bedtime routine, you know, you bathe the kids, you put them in bed, you read them a story.
link |
02:05:38.240
You have to go through this routine, this wind down routine for them.
link |
02:05:42.240
And then they fall asleep wonderfully.
link |
02:05:44.240
Why do we abandon that as adults?
link |
02:05:47.240
We need that same wind down routine.
link |
02:05:51.240
So that's been the other thing that's been very helpful to me.
link |
02:05:54.240
So don't do anything different if you have a bad night of sleep.
link |
02:05:58.240
Keep doing the same thing.
link |
02:06:00.240
Manage your anxiety, understand it, rationalize it.
link |
02:06:04.240
Then meditation and then finally having some kind of disengagement wind down routine.
link |
02:06:11.240
Those are the four things that have been very helpful to me.
link |
02:06:15.240
That's brilliant.
link |
02:06:16.240
So the regularities really do a lot of work against insomnia.
link |
02:06:20.240
Is it possible to have a healthy sleep life without the regularities?
link |
02:06:30.240
I say that because I'm all over the place and I've gotten good in being all over the place.
link |
02:06:37.240
So I'll often, like what happens, I'll go stretches of time.
link |
02:06:42.240
There'll be sometimes a month where my days are like, this is embarrassing to admit, but they're like...
link |
02:06:49.240
It's just you and I here.
link |
02:06:51.240
It's like 28 hours or 30 hour days.
link |
02:06:55.240
I'll just go all the way around comfortably and happily.
link |
02:07:00.240
I love it.
link |
02:07:01.240
And then there'll be a nap.
link |
02:07:03.240
If you add up to hours when I'm just sleeping as much as I want,
link |
02:07:09.240
it'll probably be like six hour average per 24 hours.
link |
02:07:14.240
So it works out nicely, maybe even seven hours.
link |
02:07:18.240
But it's obviously irregular and there's chaos in the whole thing.
link |
02:07:23.240
Sometimes it's shorter sleep, sometimes it's longer.
link |
02:07:26.240
Is that totally not a good thing?
link |
02:07:29.240
Do you think?
link |
02:07:30.240
The best evidence that we have to speak to this question is people who are doing rotating shifts.
link |
02:07:37.240
And unfortunately, the news is not good.
link |
02:07:41.240
They usually have a higher instance of many diseases such as depression, diabetes, cardiovascular disease, obesity, stroke.
link |
02:07:59.240
And again, that's just me communicating the data that we have.
link |
02:08:05.240
And I'm not telling you that you should do anything different.
link |
02:08:08.240
The other thing is that there's nothing in your biology that suggests that that's how your body was designed to sleep.
link |
02:08:17.240
It is a system that loves habit.
link |
02:08:22.240
If your circadian clock in your brain is called the suprachiasmatic nucleus,
link |
02:08:30.240
sits in the middle of your brain, had a personality trait, it would be a creature of habit.
link |
02:08:36.240
It loves habit.
link |
02:08:38.240
That's how your biology is designed to work is through very archetypal, prototypical, expected cycles.
link |
02:08:47.240
And when we do something different to that, then you start to see some of the pressure, stress fractures in the system.
link |
02:08:58.240
But again, to your point, if that's something that you don't mind adopting and understanding,
link |
02:09:09.240
then I think you should keep doing what you're doing.
link |
02:09:12.240
Yeah, it's complicated.
link |
02:09:13.240
Of course, you have to be a student of your own body and explore it.
link |
02:09:16.240
One of the reasons I want to have kids is kids enforce a stricter schedule.
link |
02:09:23.240
I think I definitely feel that I'm not living the sort of data wise, scientifically speaking, the optimal life.
link |
02:09:34.240
And me just living the way I want to live day to day is perhaps not the optimal way.
link |
02:09:39.240
And there's certain things that I've seen, very successful people that I know in my life when they have kids.
link |
02:09:48.240
They actually, the productivity goes up, they get their shit together, there's a lot of aspects that...
link |
02:09:53.240
Regularity, yeah.
link |
02:09:54.240
Yeah, the regularity.
link |
02:09:55.240
I mean, that creature's a habit.
link |
02:09:56.240
That's the thing.
link |
02:09:57.240
That's power.
link |
02:09:58.240
And then you start to optimally use the hours you have in a day.
link |
02:10:02.240
Let me ask you about that.
link |
02:10:03.240
Well, actually, I just have one quick point on that too.
link |
02:10:06.240
You know, we often think about sleep as a cost, but instead I think of sleep as an investment.
link |
02:10:18.240
And the reason is because your effectiveness and your efficiency when you're well slept typically exceeds that when you're not.
link |
02:10:26.240
And to me, it's the idea of if I'm going to boil a pot of water, why would I boil it on medium when I could boil it in half the time on high?
link |
02:10:38.240
Yeah.
link |
02:10:39.240
And I sometimes worry that when I speak to Fortune 500 companies and, you know, they're of this mentality of, you know, long hours getting people to rise and grind.
link |
02:10:52.240
The first point is that after about 20 hours of being awake, a human being is as cognitively as impaired as they would be if they were legally drunk.
link |
02:11:01.240
And the reason I bring that point up is because I don't know any company or CEO who would say, I've got this great team that drunk all the time.
link |
02:11:12.240
But we often lord the airport warrior who's flown through three different time zones in the past two days is on email at 2am and then is, you know, in the office at six.
link |
02:11:25.240
And I think there is some aspect, not in all people, but there is sort of some aspect of that slight sleep machismo.
link |
02:11:32.240
And that's not what you are very different, you know, you are driven by a purity of passion and a very authentic, incredibly genuine goal of wanting to do something remarkable with your life.
link |
02:11:47.240
That's not the issue I think I'm speaking about.
link |
02:11:52.240
It's just simply that I think the this notion of wanting to be awake for longer to try and get more done and sometimes be at odds with the fact that you can actually get so much more done if you're well slept.
link |
02:12:12.240
And it's this trade off.
link |
02:12:14.240
I actually admire people that take the big risk and work hard, whether that means staying up late at night, all those kinds of things.
link |
02:12:21.240
But it cannot be in the framework in the context like what Edison said, which is sleep feels like a waste of time.
link |
02:12:29.240
So like, if you're not sleeping, because you think sleep is stupid, that's totally wrong.
link |
02:12:36.240
But if you're not sleeping because you're deeply passionate about something that to me, it's a gray area, of course, but that to me is much more admirable.
link |
02:12:45.240
And everything you're espousing is saying like, whatever the hell you're doing, you better be aware of the sleep long term and short term is really good for you.
link |
02:12:54.240
So if you're not sleeping, you're sacrificing, just make sure you're sacrificing for the right thing.
link |
02:12:59.240
I see vodka and getting drunk the same way.
link |
02:13:03.240
I know it's not good for me.
link |
02:13:05.240
I know I'm not going to feel good days after.
link |
02:13:08.240
I know it's going to decrease my performance.
link |
02:13:10.240
There's nothing positive about it, except it introduces chaos in my life that introduces beautiful experiences that I would not otherwise have.
link |
02:13:22.240
It creates like this turmoil of social interaction that ultimately makes me happy that I've experienced them in the moment and later the stories you get to meet new people.
link |
02:13:34.240
Alcohol in this society is an incredible facilitator of that.
link |
02:13:40.240
So that's a good example of not sleeping and drinking way too much vodka.
link |
02:13:46.240
Again, it's this notion of life is to be lived to a degree.
link |
02:13:51.240
But if you do have children, I think one of the other things that then maybe comes into the picture is the fact that now there are other people that you have to live with.
link |
02:14:03.240
For example, that you have to live for than yourself.
link |
02:14:07.240
Yeah, but come on.
link |
02:14:09.240
Once they're old enough, if you can't defend for yourself, you're too weak, get stronger.
link |
02:14:15.240
It's going to be that kind of fatherhood.
link |
02:14:17.240
I got it.
link |
02:14:19.240
I'm understanding so much more about like screaming.
link |
02:14:23.240
That's why you have to have, for me, my wife would be probably softer.
link |
02:14:29.240
It's good cop, bad cop, because I think I'm...
link |
02:14:33.240
But of course, actually, because I don't have kids, I've seen some tough dudes when they have kids become the softies.
link |
02:14:44.240
They do everything for their kids.
link |
02:14:47.240
It totally transforms their life.
link |
02:14:50.240
Joe Rogan is an example that has just seen so many tough guys completely become changed by having kids, which is fascinating to watch,
link |
02:15:00.240
because it just shows you how meaningful having kids is for a lot of people.
link |
02:15:04.240
Although, I would say having Chastity with Joe for some time, I think he is a delightful, sweetheart, independent of children.
link |
02:15:15.240
I think, don't get me wrong, I don't want to be in a ring with him.
link |
02:15:19.240
He would pace me five ways till Tuesday.
link |
02:15:22.240
But I think he's a desperately sweet man and a very, very smart individual.
link |
02:15:27.240
But he talks about the compassion he's gained from realizing just watching kids grow up, that we were all kids at some point.
link |
02:15:35.240
You get a new perspective.
link |
02:15:37.240
I think just like me, I still get this with him.
link |
02:15:40.240
He's super competitive and there's a certain way to approach life.
link |
02:15:45.240
You're striving to do great things and you're competitive against others.
link |
02:15:49.240
And that intensity or that aggression, that can lack compassion sometimes and empathy.
link |
02:15:56.240
And when you have children, you get a sense like, oh, everybody was a child at some point.
link |
02:16:00.240
Everybody was a kid and you see that whole development process.
link |
02:16:04.240
It can definitely enrich, expand your ability to be empathetic.
link |
02:16:12.240
Let me ask you about diet.
link |
02:16:15.240
So what's the connection between diet and sleep?
link |
02:16:19.240
So I do intermittent fasting sometimes only one meal a day, sometimes no meals a day.
link |
02:16:24.240
Is there a good science on the interaction between fasting and sleep?
link |
02:16:29.240
We have some data, I would prefer more, but we have data both on time restricted eating.
link |
02:16:37.240
And then we have some data on fasting to a degree.
link |
02:16:45.240
On time restricted eating, I think that it has some benefits.
link |
02:16:51.240
Although the human replication studies have actually not borne out quite the same health benefit extent
link |
02:16:57.240
that the animal studies have.
link |
02:16:59.240
There have been some disappointing studies, one here close to where we are right now at UCSF recently.
link |
02:17:06.240
So I think time restricted eating can be a good thing.
link |
02:17:09.240
And there are many benefits of time restricted eating.
link |
02:17:12.240
Is sleep one of them?
link |
02:17:14.240
No, it doesn't seem to be because there are probably at the time that we're recording this three pretty decent studies that I'm aware of.
link |
02:17:21.240
Two out of the three were in obese individuals.
link |
02:17:25.240
One out of the three were in healthy weight individuals.
link |
02:17:28.240
And what they found was that time restricted eating in all three of those studies didn't have any advantageous benefit to sleep.
link |
02:17:36.240
It didn't necessarily harm sleep, but it didn't seem to improve it.
link |
02:17:41.240
When it comes to fasting though, which is a different state, we don't have too many studies, experimental studies with long term fasting.
link |
02:17:49.240
The best data that we have is probably from religious practices.
link |
02:17:52.240
And probably the most data we have is during Ramadan where people will fast for 29 to 30 days from sunrise to sunset.
link |
02:18:03.240
And under those conditions, there are probably five distinct changes that we've seen.
link |
02:18:13.240
None of them seem to be particularly good for sleep.
link |
02:18:16.240
The first is that the amount of melatonin that you release and melatonin is a hormone.
link |
02:18:20.240
It's often called the hormone of darkness or the vampire hormone.
link |
02:18:24.240
Not because it makes you look longingly at people's necklines, but it's just because it comes out at night.
link |
02:18:30.240
Melatonin signals to your brain that and your body that it's dark, it's nighttime and it's time to sleep.
link |
02:18:36.240
Those individuals, when they were undergoing that regimen to fasting, the amount of melatonin that was released and when it was released,
link |
02:18:45.240
the amount of melatonin decreased and when it was released came later.
link |
02:18:50.240
That was the first thing.
link |
02:18:51.240
The second thing was that they ended up finding it harder to fall asleep as quickly as they normally would otherwise.
link |
02:18:59.240
The third thing was that the total amount of sleep that they were getting decreased.
link |
02:19:04.240
The fourth fascinating thing was that awake promoting chemical called orexin increased.
link |
02:19:11.240
This is why a lot of people will say, when I'm fasting, it feels like I can stay awake for longer and I'm more alert, I'm more active.
link |
02:19:21.240
I'll come back from an evolutionary perspective, why we understand that to be the case.
link |
02:19:26.240
Then the fourth factor is that fasting didn't decrease the amount of deep sleep that seemed to be unaffected.
link |
02:19:33.240
It did, however, decrease the amount of REM sleep or dream sleep.
link |
02:19:37.240
We know that REM sleep dreaming is essential for emotional first aid, mental health.
link |
02:19:42.240
It's critical for memory creativity.
link |
02:19:45.240
It's also critical for several hormone functions.
link |
02:19:47.240
It's when there's direct correlations between testosterone.
link |
02:19:52.240
Testosterone release peaks just before you go into REM sleep and during REM sleep, too.
link |
02:19:58.240
REM sleep is critical.
link |
02:20:00.240
Those are the five changes that we've seen.
link |
02:20:02.240
None of them seem to be that advantageous for sleep.
link |
02:20:06.240
The fourth point that I mentioned, which was orexin, which is this awake promoting chemical,
link |
02:20:12.240
and a good demonstration or a very sad demonstration of its power is when it becomes very deficient in the brain,
link |
02:20:19.240
and it leads to a condition called narcolepsy, where you're just unpredictable with your sleep.
link |
02:20:27.240
Orexin, when it's in high concentrations, keeps you awake when you lose it.
link |
02:20:36.240
It can put you very much into a state of narcolepsy where you're sleeping a lot of the time in unpredictable sleep.
link |
02:20:43.240
Why on earth, when you are fasting, would the brain release awake promoting chemical?
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02:20:51.240
Our answer right now is the following. One of the few times that I mentioned before that we see animals undergoing insufficient sleep
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02:21:00.240
or prolonged sleep deprivation is under conditions of starvation.
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02:21:06.240
That is an extreme evolutionary pressure.
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02:21:11.240
At that point, the brain will forgo some.
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02:21:14.240
It won't forgo all, but it will forgo some of its sleep.
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02:21:18.240
The reason is so that it can stay awake for longer because the sign of starvation is saying to the brain,
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02:21:24.240
you can't find food in your normal foraging perimeter.
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02:21:28.240
You need to stay awake for longer so you can travel outside of your perimeter for a further distance,
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02:21:34.240
and maybe you will find food and save the organism.
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02:21:37.240
In other words, when we fast, it's giving our brain this evolutionary signal that you are under conditions of starvation.
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02:21:46.240
The brain responds by saying, oh my goodness, I need to release the chemical
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02:21:50.240
that helps the organism stay awake for longer, which is a rexin, so that they can forage for more food.
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02:21:57.240
Now, of course, your brain from an evolutionary perspective doesn't know about this thing called Safeway,
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02:22:02.240
that you could easily go to and break the fast.
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02:22:05.240
That's how we understand fasting.
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02:22:08.240
I think my dear friend, Peter Thier, has done a lot of work in this area too.
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02:22:14.240
I think fasting and David Sinclair is brilliant work.
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02:22:17.240
Goodness me, what an individual too.
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02:22:20.240
The work is pretty clear there that time restricted eating and fasting have wonderful health benefits.
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02:22:28.240
Fasting creates this thing called hermesis, just like exercise and low level stress and sauna, heat, chalk.
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02:22:39.240
Hormesis is a biological process, I think, as David Sinclair once said in simple layman's terms.
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02:22:45.240
What doesn't kill you makes you stronger.
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02:22:48.240
I think there is certainly good data that fasting and time restricted eating has many benefits.
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02:22:56.240
Is sleep one of them?
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02:22:57.240
It doesn't seem to be.
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02:22:58.240
It doesn't seem to enhance sleep.
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02:23:00.240
It's interesting to understand its effects on sleep.
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02:23:04.240
I've fasted, it's a study of NF2.
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02:23:12.240
I once fasted 72 hours and another time 48 hours.
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02:23:16.240
I found that I got much less sleep and it was very restful though.
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02:23:22.240
I hesitate to say this, but this is how I felt, which is I needed less sleep.
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02:23:26.240
I wonder if my brain is deceiving me because it feels like I'm getting a whole extra amount of focus for free.
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02:23:34.240
I wonder if there's long term impacts of that.
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02:23:39.240
If I fast 24 hours, I get the same amount of calories, one meal a day.
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02:23:45.240
There's a little bit of discomfort, like maybe your body gets a little bit colder.
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02:23:50.240
Maybe there's just hunger, but the amount of focus is crazy.
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02:23:58.240
I'm a little suspicious of that.
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02:24:02.240
I feel like I'm getting something for free.
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02:24:04.240
I'm the same way with sweetener, like Splendor or something.
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02:24:08.240
It's got to be really bad for you, right?
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02:24:10.240
Because why is it so tasty?
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02:24:12.240
I think, as we said before, with biology, if there's a gain, there's often a cost too.
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02:24:25.240
But we at least understand the biological basis of what you're describing.
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02:24:29.240
It's not that you actually don't need less sleep.
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02:24:33.240
It's that this chemical is present that forces you more awake.
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02:24:39.240
Subjectively, you feel as though, I don't need as much sleep because I'm wide awake.
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02:24:45.240
Those two things are quite different.
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02:24:47.240
It's not as though your sleep need has decreased.
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02:24:51.240
It's that your brain has hit the overdrive switch, the overboost switch,
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02:24:55.240
to say, we need to keep you awake because food is in short supply.
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02:25:00.240
You mentioned during sleep, there's a simulation, all those kinds of things for learning purposes.
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02:25:05.240
You mentioned the five ways in which we become psychotic in dreams.
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02:25:10.240
What do you think dreams are about?
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02:25:14.240
Why do you think we dream?
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02:25:17.240
What place do we go to when we dream?
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02:25:20.240
And why are they useful?
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02:25:22.240
Not just the assimilation aspect, but just all the crazy visuals that we get with dreams.
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02:25:29.240
Is there something you can speak to that's actually useful?
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02:25:33.240
Why we have such fun experiences in that dream world?
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02:25:39.240
One of the camps in the sleep field is that dreams are meaningless,
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02:25:46.240
that they are an epiphenomenal byproduct of this thing called REM sleep
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02:25:51.240
from which dreams come from as a physiological state.
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02:25:55.240
The analogy would be, let's think of a light bulb,
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02:26:00.240
that the reason that you create the apparatus of a light bulb is to produce this thing called light
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02:26:06.240
in the same way that we've evolved to this thing called REM sleep to serve whatever functions REM sleep.
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02:26:13.240
But it turns out that when you create light in that way, you also produce something called heat.
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02:26:19.240
It was never the reason that you designed the light bulb, it's just what happens when you create light in that way.
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02:26:26.240
And the belief so too was that dreaming was essentially the heat of the light bulb,
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02:26:32.240
that REM sleep is critical, but when you have REM sleep with a complex brain like ours,
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02:26:38.240
you also produce this conscious epiphenomenon called dreaming.
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02:26:44.240
I don't believe that for a second.
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02:26:47.240
And from a simple perspective is that I suspect that dreaming is more metabolically costly as a conscious experience than not dreaming.
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02:26:56.240
So you could still have REM sleep, but absent the conscious experience of dreaming was probably less metabolically costly.
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02:27:05.240
And whenever Mother Nature burns the energy unit called ATP, which is the most valuable thing,
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02:27:13.240
there's usually a reason for it. So if it's more energetically demanding, then I suspect that there is a function to it.
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02:27:22.240
And we've now since discovered that dreams have a function.
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02:27:26.240
The first, as we mentioned, creativity.
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02:27:28.240
The second is that dreams provide a form of overnight therapy.
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02:27:34.240
Dreaming is a form of emotional first aid. And it's during dream sleep at night that we take these difficult, painful experiences that we've had during the day, sometimes traumatic.
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02:27:46.240
And dream sleep acts almost like a nocturnal soothing balm.
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02:27:51.240
And it sort of just takes the sharp edges off those difficult, painful experiences so that you come back the next day and you feel better about them.
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02:28:01.240
And so I think in that sense, dreaming, it's not time that heals all wounds.
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02:28:07.240
It's time during dream sleep that provides emotional convalescence.
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02:28:12.240
So dreaming is almost a form of, you know, emotional windscreen wipers.
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02:28:19.240
And I think, and by the way, it's not just that you dream.
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02:28:25.240
It's what you dream about that also matters.
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02:28:30.240
But for example, scientists have done studies with learning in memory where they have people learn a virtual maze.
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02:28:37.240
And what they discovered was that those people who then dreamed but dreamed of the maze were the only ones who, when they woke up, ended up being better at navigating the maze.
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02:28:51.240
Whereas those people who dreamed but didn't dream about the maze itself, they were no better at navigating the maze.
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02:28:58.240
It's not just that you, it's not sort of necessary but not sufficient.
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02:29:02.240
It's necessary that you dream, but it's not sufficient to produce the benefit.
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02:29:07.240
You have to be dreaming about certain things itself.
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02:29:10.240
And the same is true for mental health.
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02:29:13.240
What we've discovered is that people who are going through a very difficult experience, a trauma, for example, a very painful divorce, those people who are dreaming but dreaming of that difficult event itself,
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02:29:26.240
they go on to gain resolution to their clinical depression one year later.
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02:29:31.240
Whereas people who were dreaming just as much but not dreaming about the trauma itself did not go on to gain as much clinical resolution to their depression.
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02:29:42.240
So I think to me, those are the lines of evidence that tell me dreaming is not epiphenomenal.
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02:29:50.240
And it's not just about the act of dreaming, it's about the content of the dreams, not just the fact of a dream itself.
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02:30:00.240
It's first of all, it's fascinating, it makes a lot of sense, but then immediately takes my mind to, from an engineering perspective, how that could be useful in, for example, AI systems.
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02:30:11.240
If you think about dreaming as an important part about learning and cognition and filtering previous memories of what's important, integrating them, maybe you can correct me,
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02:30:27.240
but I see dreaming as a kind of simulation of worlds that are not constrained by physics.
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02:30:34.240
So you get a chance to take some of your memories, some of your thoughts, some of your anxieties and play with them, construct virtual worlds and see how it evolves.
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02:30:46.240
To play with those worlds in a safe environment of your mind, safe in quotes, because you can probably get into a lot of trouble with the places your mind will go.
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02:30:57.240
And this definitely is applied in much cruder ways in artificial intelligence.
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02:31:06.240
So one context in which this is applied is the process called self play, which is reinforcement learning where agents play against itself or versions of itself.
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02:31:20.240
It's all simulated of trying different versions of themselves and playing against each other to see what ends up being a good.
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02:31:29.240
The ultimate goal is to learn a function that represents what is good and what is not good in terms of how you should act in the world.
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02:31:36.240
Right, you create a set of decision weights based on experience and you constantly update those weights based on ongoing learning.
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02:31:43.240
But the experience is artificially created versus actual real data.
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02:31:49.240
It's a crude approximation where dreams are, which is you're hallucinating a lot of things to see which things are actually.
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02:31:56.240
No, I think it's and it's been a theory that's been put forward, which is that dreaming is a virtual reality test space that is largely consequence free.
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02:32:07.240
What an incredible gift to give a conscious mind each and every night.
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02:32:13.240
Now, the conscious mind, the human mind is very good at constructing dreams that are nevertheless useful for you.
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02:32:20.240
Like they're wild and crazy, but they're such that they are still grounded in reality to a degree where anything you learn in dreams might be useful in reality.
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02:32:32.240
This is a very difficult thing to do because it requires a lot of intelligence, it requires consciousness.
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02:32:38.240
This has been effectively recently being used in self supervised learning for computer vision with the process of what's called data augmentation.
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02:32:49.240
That's a very crude version of dreams, which is you take data and you mess with it and you start to learn how a picture of a cat truly represents a cat by messing with it in different ways.
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02:33:06.240
Now, the crude methods currently are cropping, rotating, distorting, all that kind of stuff.
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02:33:11.240
But you can imagine much more complicated generative processes that start hallucinating different cats in order for you to understand deeply of what it means for something to look like a cat.
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02:33:25.240
What is the prototype of the archetype of a cat?
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02:33:28.240
That's a very difficult process for computer vision to go from what are the pixels that are usually associated with a cat to what is a cat in the visual space?
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02:33:42.240
In the three dimensional visual space that is projected on an image, on a two dimensional image, what is a cat?
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02:33:49.240
Those are fundamentally philosophical questions that we humans don't know the answer to, like linguistically.
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02:33:57.240
But when we look at a picture of a cat and a dog, we can usually tell pretty damn well what's the difference.
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02:34:04.240
And I don't know what that is because you can't reduce that to pointy ears or non pointy ears, furry or not furry, something about the eyes.
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02:34:12.240
It's been a longstanding issue in cognitive neuroscience too, is how does the brain create an archetype?
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02:34:20.240
How does it create schemas that have general applicability but yet still obtain specificity?
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02:34:29.240
That's a very difficult challenge.
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02:34:31.240
We can do it, we do it.
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02:34:33.240
It's rather bloody amazing.
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02:34:35.240
And it seems like part of the toolbox is this controlled hallucination, which is dreams.
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02:34:40.240
Well, it's a relaxing of the rigid constraints.
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02:34:45.240
I often think of dreaming as it's from an information processing standpoint.
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02:34:52.240
The prison guards are away and the prisoners are running amok in a delightful way.
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02:34:58.240
And part of the reason is because when you go into dream sleep, the rational part of your brain called the prefrontal cortex, which is the part.
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02:35:05.240
It's like the CEO of the brain.
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02:35:07.240
It's very good at making high level rational top down decisions and controlled actions.
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02:35:12.240
That part of the brain is shut down during REM sleep.
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02:35:17.240
But then emotional centers, memory centers, visual centers, motoric centers, all of those centers actually become more active.
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02:35:27.240
In fact, some of them are more active than when we're awake in the dream state.
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02:35:33.240
So your brain from a neural architecture perspective is radically different.
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02:35:39.240
Its network feature is not the same as wakefulness.
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02:35:44.240
And I think this is an immensely beneficial thing that we have at least two different rational and irrational conscious states that we do information processing in.
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02:35:56.240
The rational, the veritical, the page one of the Google search is wakefulness.
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02:36:01.240
And the more irrational, illogical, hyper associative Google page 20 is the REM sleep.
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02:36:09.240
Both I think are critical, both are necessary.
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02:36:12.240
That's fascinating.
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02:36:13.240
And again, fascinating to see how that could be integrated in the machines to help them learn better and to reason better.
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02:36:22.240
And in some ways, we also know it from a chemical perspective too.
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02:36:26.240
If you go into dream sleep, it is a neurochemical cocktail like no other that we see in the at the rest of the 24 hour state.
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02:36:35.240
There is a chemical called noradrenaline or norepinephrine in the brain.
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02:36:40.240
And you know if it's sister chemical in the body called adrenaline, but upstairs in the brain noradrenaline is very good at creating a very hyper focused, attentive, narrow.
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02:36:52.240
It's sort of very convergent way of thinking to a point sharp focus.
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02:37:00.240
That's the only thing the spotlight of consciousness is very narrow.
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02:37:04.240
That's noradrenaline.
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02:37:06.240
When you remove noradrenaline, then you go from a high SNR high signal to noise ratio where it's just you and I in this moment.
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02:37:17.240
I don't even know what's going on elsewhere.
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02:37:19.240
And with you, noradrenaline is present.
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02:37:22.240
But when you go into REM sleep, it is the only time during the 24 hour period where your brain is devoid of any noradrenaline.
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02:37:30.240
It is completely shut off.
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02:37:32.240
And so the signal to noise ratio is very different.
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02:37:35.240
It's almost as though we're injecting a greater amount of noise into the neural architecture of the brain during dream sleep.
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02:37:42.240
As if it's chemically brute forced into this relaxed, associative memory processing state.
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02:37:50.240
And then from an anatomical perspective, just as I described the prefrontal cortex goes down and other regions light up.
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02:37:58.240
So it is a state that seems to be very, I mean, if you were to show me a brain scan of REM sleep and tell me that it's not REM sleep.
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02:38:08.240
Just say, look, based on the pattern of this brain activity, what would you say is going on in this person's mind?
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02:38:14.240
I would say, well, they're probably not rational.
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02:38:16.240
They're probably not having logical thought because their prefrontal cortex is down.
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02:38:19.240
They're probably feeling very emotional because their amygdala is is active, which is an emotional center of the brain.
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02:38:25.240
They're definitely going to be thinking visually because the back of the brain is lit up the visual cortex.
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02:38:30.240
It's probably going to be filled with past experience and autobiographical memories because their their memory centers are lighting up.
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02:38:39.240
And there's probably going to be movement because their motor cortex is very active.
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02:38:43.240
That to me sounds very much like a dream.
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02:38:45.240
And that's exactly what we see in brain scanners when we've put people inside of them.
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02:38:49.240
One of the things I notice sleep effects is my ability to see the beauty in the world.
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02:38:59.240
So what do you think is the connection to sleep in your emotional life?
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02:39:05.240
Your ability to love other human beings and love life?
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02:39:12.240
Yeah, I think it's it's very powerful and strong.
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02:39:19.240
So we've done a lot of work in the field of sleep and emotion and sleep and moods.
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02:39:24.240
And you can separate your emotions into two main buckets, positive and negative.
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02:39:31.240
And what's interesting is that when you are sleep deprived and the more hours that you go into being awake and the fewer hours that you've had to sleep,
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02:39:41.240
your your negative mood starts to increase.
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02:39:46.240
And we know which individual types of emotions are changing.
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02:39:52.240
I've got a wonderful postdoc in my lab called Etty Ben Simon who's doing some incredible work on trying to understand the emotional individual emotional tapestry of affective meltdown when you're not getting sufficient sleep.
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02:40:11.240
But let's just keep with two dimensions, positive and negative.
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02:40:15.240
Most people would think, well, it's the negative that takes the biggest hit when I'm sleep deprived.
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02:40:20.240
It's not by probably a log order magnitude larger is a hit on your positive emotions.
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02:40:28.240
In other words, you stop gaining pleasure from normally pleasurable things.
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02:40:34.240
And it's a state that we call anhedonia.
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02:40:37.240
And anhedonia is the state that we often call depression.
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02:40:43.240
So depression to most people's surprise isn't necessarily that you're always feeling negative emotions.
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02:40:51.240
It's often more about the fact that you lose the pleasure in the good things in life.
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02:40:58.240
That's what we call anhedonia.
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02:41:00.240
That's what we see in sleep and insufficient sleep.
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02:41:03.240
And it happens quite quickly.
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02:41:05.240
Yeah, it's kind of fascinating. I think I do it's not depression, but like it's a it's a stroll into that direction,
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02:41:15.240
which is when I'm sleep deprived, I stop being able to see the meaning in life.
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02:41:21.240
The things that gave me meanings starts to lose meaning like stupid.
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02:41:26.240
It makes me realize how enjoyable everything is in my life because when I start to lose it when I'm severely sleep deprived,
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02:41:33.240
you start to see how much life sucks when you lose it.
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02:41:36.240
But that said, I'm just cognizant enough that sleep fixes all of that.
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02:41:41.240
So I use those states for what they're worth.
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02:41:44.240
In fact, I personally like to pay attention to the things that bother me in doing that time.
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02:41:52.240
Because they also reveal important information to me.
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02:41:57.240
That's interesting.
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02:41:59.240
That's usually like a roll shock.
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02:42:01.240
Yeah, I mean, so I find when I fast combine with sleep deprivation,
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02:42:07.240
I'm clear to see with people clear in identifying the things that are not going right in my life.
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02:42:15.240
Or people that I'm working with are not doing as good of a job as they could be doing.
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02:42:21.240
Like people that are negative in my life, I'm more able to identify them.
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02:42:27.240
So I don't act on that. It's a very bad time to act on those decisions.
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02:42:31.240
Good point, well made.
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02:42:33.240
I'm recording that information because I usually when I'm well rested and happy,
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02:42:39.240
I see the beauty in everybody, which can get you into trouble.
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02:42:43.240
You have to balance those two things.
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02:42:45.240
But yes, it's fascinating.
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02:42:47.240
There's irony there too, which is the fact that when you're well rested and well slept,
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02:42:51.240
as you said, you see the beauty in life and it sort of enlivens you and sort of gives you a quality of life
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02:43:01.240
that's emotionally very different.
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02:43:03.240
Yet then we are contrasting that against the need for not getting enough sleep
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02:43:15.240
because of the beautiful things that you want to accomplish in life.
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02:43:19.240
And I don't actually see them as completely counterintuitive or paradoxical
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02:43:29.240
because I still think that you can strive for all of the brilliant things that you are striving for
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02:43:35.240
to have the monumental goals, the Herculean challenges that you wish to take on and solve.
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02:43:41.240
They can still enthrall you and excite you and stimulate you.
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02:43:47.240
But because of the insufficient sleep that they can or that goal can produce,
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02:43:55.240
it will shave off the beauty of life that you experience in between.
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02:44:01.240
And again, this is just about the trade off.
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02:44:03.240
I will say though that and this is not applicable to your circumstance,
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02:44:11.240
we do know that insufficient sleep is very strongly linked to suicide ideation,
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02:44:17.240
suicide attempts and tragically suicide completion as well.
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02:44:23.240
And in fact, in 20 years of studying sleep,
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02:44:27.240
we have not been able to discover a single psychiatric condition in which sleep is normal.
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02:44:33.240
And I think that that is a profound state. I think it tells us so much about the role of sleep
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02:44:41.240
as a potential causal agent in psychiatric conditions.
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02:44:45.240
I also think it's a potential sign that we should be using sleep as a tool
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02:44:49.240
for the prevention of grave mental illness.
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02:44:51.240
Yeah, it's both a cause and a solution.
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02:44:55.240
I mean, me personally, I've gone through a few dark periods quite recently
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02:45:01.240
and it was almost always sleep is not the cause,
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02:45:05.240
but sleep is the catalyst from going to a bad time to a very bad time.
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02:45:11.240
Yeah. And so it's definitely true and it's funny how sleep can just cure all of that.
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02:45:17.240
There's actually a beautiful quote by an American entrepreneur called E. Joseph Kosman
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02:45:23.240
who once said that the best bridge between despair and hope is a good night's sleep.
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02:45:29.240
And I spilled quite so much ink and hundreds of pages
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02:45:37.240
in elegantly trying to say the same thing in my book and he said it in one line
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02:45:41.240
and it's beautiful.
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02:45:43.240
What do you think is we've been talking about how to extend this life,
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02:45:47.240
how to make it a good life.
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02:45:49.240
I've been talking about love.
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02:45:53.240
What do you think is the meaning of this whole ride of life of life?
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02:45:57.240
Why do we want to make it a good one?
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02:46:01.240
Do you think there's a meaning? Do you think there's an answer to the why?
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02:46:05.240
For me personally,
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02:46:09.240
I think the meaning of life is to eat, is to sleep, is to fall in love,
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is to cry, and then to die.
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Probably race cars in between.
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02:46:29.240
Race cars? Well, there's a whole topic of sex we didn't talk about.
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That's probably in there. So should we do that?
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Maybe if you'll have me back, I will give you a round.
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02:46:39.240
Next time we will do another three hours on sex alone.
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02:46:43.240
It has been over three hours.
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I'm a big fan of your work. I think you're doing really important work.
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02:46:52.240
Even despite all the things I've been saying about the madness of my own sleep schedule,
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I think you're helping millions of people.
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02:46:59.240
It's an honor that you spend your valuable time with me
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02:47:02.240
and I can't wait until your podcast comes out.
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I'm a huge fan of podcasts. I'm a huge fan of you.
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02:47:08.240
It's just an honor to know you and to get a chance hopefully in the future
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to work together with you. You're a brilliant man
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02:47:15.240
and you're doing amazing things and I feel immensely honored
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02:47:20.240
to have met you to now know you and to start calling you a friend.
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Thank you for what you do for the world and for me included.
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02:47:31.240
Thank you, Matt. Take care.
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02:47:34.240
Thanks for listening to this conversation with Matt Walker
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02:47:37.240
and thank you to stamps.com, Squarespace,
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02:47:40.240
Let It Greens, BetterHelp, and On It.
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02:47:43.240
Check them out in the description to support this podcast.
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02:47:46.240
And now, let me leave you with some words from Nikola Tesla
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who we discussed in this podcast as sleeping very few hours a night.
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All that was great in the past was ridiculed, condemned, combated, and suppressed
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02:47:59.240
only to emerge all the more powerfully, all the more triumphantly from the struggle.
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Thank you for listening and hope to see you next time.