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Demis Hassabis: DeepMind - AI, Superintelligence & the Future of Humanity | Lex Fridman Podcast #299


small model | large model

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The following is a conversation with Demis Hassabis,
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CEO and co founder of DeepMind,
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a company that has published and built
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some of the most incredible artificial intelligence systems
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in the history of computing,
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including AlphaZero that learned all by itself
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to play the game of go better than any human in the world
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and AlphaFold2 that solved protein folding.
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Both tasks considered nearly impossible
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for a very long time.
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Demis is widely considered to be
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one of the most brilliant and impactful humans
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in the history of artificial intelligence
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and science and engineering in general.
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This was truly an honor and a pleasure for me
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to finally sit down with him for this conversation.
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And I'm sure we will talk many times again in the future.
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This is the Lux Readman podcast.
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To support it, please check out our sponsors
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in the description.
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And now, dear friends, here's Demis Hassabis.
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Let's start with a bit of a personal question.
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Am I an AI program you wrote to interview people
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until I get good enough to interview you?
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Well, I'd be impressed if you were.
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I'd be impressed by myself if you were.
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I don't think we're quite up to that yet,
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but maybe you're from the future, Lex.
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If you did, would you tell me?
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Is that a good thing to tell a language model
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that's tasked with interviewing
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that it is, in fact, AI?
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Maybe we're in a kind of meta Turing test.
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Probably it would be a good idea not to tell you,
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so it doesn't change your behavior, right?
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This is a kind of link.
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Heisenberg uncertainty principle situation.
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If I told you, you'd behave differently.
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Maybe that's what's happening with us, of course.
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This is a benchmark from the future
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where they replay 2022 as a year
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before AIs were good enough yet,
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and now we want to see, is it gonna pass?
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Exactly.
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If I was such a program,
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would you be able to tell, do you think?
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So to the Turing test question,
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you've talked about the benchmark for solving intelligence.
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What would be the impressive thing?
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You've talked about winning a Nobel Prize
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and AIS system winning a Nobel Prize,
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but I still return to the Turing test as a compelling test,
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the spirit of the Turing test as a compelling test.
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Yeah, the Turing test, of course,
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it's been unbelievably influential,
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and Turing's one of my all time heroes,
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but I think if you look back at the 1950 paper,
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his original paper and read the original,
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you'll see, I don't think he meant it
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to be a rigorous formal test.
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I think it was more like a thought experiment,
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almost a bit of philosophy he was writing
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if you look at the style of the paper,
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and you can see he didn't specify it very rigorously.
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So for example, he didn't specify the knowledge
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that the expert or judge would have.
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How much time would they have to investigate this?
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So these are important parameters
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if you were gonna make it a true sort of formal test.
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And by some measures, people claim the Turing test passed
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several, a decade ago, I remember someone claiming that
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with a kind of very bog standard, normal logic model,
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because they pretended it was a kid.
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So the judges thought that the machine was a child.
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So that would be very different
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from an expert AI person interrogating a machine
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and knowing how it was built and so on.
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So I think we should probably move away from that
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as a formal test and move more towards a general test
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where we test the AI capabilities on a range of tasks
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and see if it reaches human level or above performance
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on maybe thousands, perhaps even millions of tasks
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eventually and cover the entire sort of cognitive space.
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So I think for its time,
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it was an amazing thought experiment.
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And also 1950s, obviously there's barely the dawn
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of the computer age.
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So of course he only thought about text
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and now we have a lot more different inputs.
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So yeah, maybe the better thing to test
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is the generalizability, so across multiple tasks.
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But I think it's also possible as systems like Gato show
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that eventually that might map right back to language.
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So you might be able to demonstrate your ability
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to generalize across tasks by then communicating
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your ability to generalize across tasks,
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which is kind of what we do through conversation anyway
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when we jump around.
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Ultimately what's in there in that conversation
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is not just you moving around knowledge,
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it's you moving around like these entirely different
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modalities of understanding that ultimately map
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to your ability to operate successfully
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in all of these domains, which you can think of as tasks.
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Yeah, I think certainly we as humans use language
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as our main generalization communication tool.
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So I think we end up thinking in language
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and expressing our solutions in language.
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So it's going to be a very powerful mode in which
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to explain the system, to explain what it's doing.
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But I don't think it's the only modality that matters.
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So I think there's going to be a lot of different ways
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to express capabilities other than just language.
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Yeah, visual, robotics, body language,
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yeah, actions, the interactive aspect of all that.
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That's all part of it.
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But what's interesting with Gato is that
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it's sort of pushing prediction to the maximum
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in terms of like mapping arbitrary sequences
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to other sequences and sort of just predicting
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what's going to happen next.
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So prediction seems to be fundamental to intelligence.
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And what you're predicting doesn't so much matter.
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Yeah, it seems like you can generalize that quite well.
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So obviously language models predict the next word,
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Gato predicts potentially any action or any token.
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And it's just the beginning really.
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It's our most general agent one could call it so far,
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but that itself can be scaled up massively more
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than we've done so far.
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And obviously we're in the middle of doing that.
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But the big part of solving AGI is creating benchmarks
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that help us get closer and closer,
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sort of creating benchmarks that test the generalizability.
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And it's just still interesting that this fella,
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Alan Turing, was one of the first
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and probably still one of the only people
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that was trying, maybe philosophically,
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but was trying to formulate a benchmark
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that could be followed.
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It is, even though it's fuzzy,
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it's still sufficiently rigorous
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to where you can run that test.
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And I still think something like the Turing test
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will, at the end of the day,
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be the thing that truly impresses other humans
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so that you can have a close friend who's an AI system.
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And for that friend to be a good friend,
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they're going to have to be able to play StarCraft
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and they're gonna have to do all of these tasks,
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get you a beer, so the robotics tasks,
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play games with you, use language,
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humor, all of those kinds of things.
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But that ultimately can boil down to language.
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It feels like, not in terms of the AI community,
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but in terms of the actual impact
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of general intelligence on the world,
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it feels like language will be the place
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where it truly shines.
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I think so, because it's such an important
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kind of input output for us.
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I think you're right.
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I think the Turing test,
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the kind of the philosophy behind it,
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which is the idea of can a machine mimic
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the behaviors of a human?
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And I would say wider than just language and text,
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then in terms of actions and everything else,
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creativity, all these things,
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then if it can sort of match or exceed
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human cognitive capabilities,
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then I think we have a true intelligence.
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So from that perspective, you're right.
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I think he did formulate the right kind of setup.
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I just, I think there'll be a kind of humor
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in the AI systems of the future looking back
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to this conversation and thinking about the Turing test
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and also thinking about by that time,
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they would know which year they were finally able
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to sort of cross the threshold of human level intelligence
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and think how funny it is that we humans
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were still confused about this whole problem
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that has been long ago been solved.
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Well, hello to the AI agents of the future.
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Anyway, so going back to your journey,
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when did you fall in love with programming first?
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Well, I was pretty young age actually.
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So, I started off, actually games was my first love.
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So starting to play chess when I was around four years old
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and then it was actually with winnings
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from a chess competition that I managed
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to buy my first chess computer
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when I was about eight years old.
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It was a ZX Spectrum, which was hugely popular
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in the UK at the time.
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And it was amazing machine because I think it trained
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a whole generation of programmers in the UK
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because it was so accessible.
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You know, you literally switched it on
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and there was the basic prompt
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and you could just get going.
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And my parents didn't really know anything about computers.
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So, but because it was my money from a chess competition,
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I could say I wanted to buy it.
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And then, you know, I just went to bookstores,
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got books on programming and started typing in,
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you know, the programming code.
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And then of course, once you start doing that,
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you start adjusting it and then making your own games.
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And that's when I fell in love with computers
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and realized that they were a very magical device.
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In a way, I kind of, I wouldn't have been able
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to explain this at the time,
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but I felt that they were sort of almost
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a magical extension of your mind.
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I always had this feeling and I've always loved this
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about computers that you can set them off doing something,
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some task for you, you can go to sleep,
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come back the next day and it's solved.
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You know, that feels magical to me.
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So, I mean, all machines do that to some extent.
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They all enhance our natural capabilities.
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Obviously cars make us, allow us to move faster
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than we can run, but this was a machine to extend the mind.
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And then of course, AI is the ultimate expression
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of what a machine may be able to do or learn.
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So very naturally for me, that thought extended
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into AI quite quickly.
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Do you remember the programming language
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that was first started and was it special to the machine?
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No, I think it was just basic on the ZX Spectrum.
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I don't know what specific form it was.
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And then later on I got a Commodore Amiga,
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which was a fantastic machine.
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Now you're just showing off.
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So yeah, well, lots of my friends had Atari STs
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and I managed to get Amigas, it was a bit more powerful
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and that was incredible and used to do programming
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in assembler and also Amos basic,
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this specific form of basic, it was incredible actually.
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So I learned all my coding skills.
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And when did you fall in love with AI?
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So when did you first start to gain an understanding
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that you can not just write programs
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that do some mathematical operations for you
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while you sleep, but something that's akin
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to bringing an entity to life,
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sort of a thing that can figure out something
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more complicated than a simple mathematical operation.
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Yeah, so there was a few stages for me
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all while I was very young.
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So first of all, as I was trying to improve
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at playing chess, I was captaining
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various England junior chess teams.
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And at the time when I was about maybe 10, 11 years old,
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I was gonna become a professional chess player.
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That was my first thought.
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So that dream was there to try to get
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to the highest levels of chess.
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Yeah, so when I was about 12 years old,
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I got to master standard and I was second highest rated
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player in the world to Judith Polgar,
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who obviously ended up being an amazing chess player
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and a world women's champion.
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And when I was trying to improve at chess,
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where what you do is you obviously, first of all,
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you're trying to improve your own thinking processes.
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So that leads you to thinking about thinking,
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how is your brain coming up with these ideas?
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Why is it making mistakes?
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How can you improve that thought process?
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But the second thing is that you,
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it was just the beginning, this was like in the early 80s,
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mid 80s of chess computers.
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If you remember, they were physical balls
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like the one we have in front of us.
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And you press down the squares.
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And I think Kasparov had a branded version of it
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that I got.
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And you used to, they're not as strong as they are today,
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but they were pretty strong and you used to practice
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against them to try and improve your openings
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and other things.
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And so I remember, I think I probably got my first one,
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I was around 11 or 12.
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And I remember thinking, this is amazing,
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how has someone programmed this chess board to play chess?
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And it was very formative book I bought,
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which was called The Chess Computer Handbook
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by David Levy.
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This thing came out in 1984 or something.
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So I must've got it when I was about 11, 12.
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And it explained fully how these chess programs were made.
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And I remember my first AI program
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being programming my Amiga.
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It couldn't, it wasn't powerful enough to play chess.
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I couldn't write a whole chess program,
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but I wrote a program for it to play Othello or reverse it,
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sometimes called I think in the US.
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And so a slightly simpler game than chess,
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but I used all of the principles that chess programs had,
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alpha, beta, search, all of that.
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And that was my first AI program.
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I remember that very well, I was around 12 years old.
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So that brought me into AI.
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And then the second part was later on,
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when I was around 16, 17,
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and I was writing games professionally, designing games,
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writing a game called Theme Park,
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which had AI as a core gameplay component
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as part of the simulation.
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And it sold millions of copies around the world.
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And people loved the way that the AI,
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even though it was relatively simple
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by today's AI standards,
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was reacting to the way you as the player played it.
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So it was called a sandbox game.
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So it was one of the first types of games like that,
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along with SimCity.
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And it meant that every game you played was unique.
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Is there something you could say just on a small tangent
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about really impressive AI
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from a game design, human enjoyment perspective,
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really impressive AI that you've seen in games
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and maybe what does it take to create an AI system?
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And how hard of a problem is that?
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So a million questions just as a brief tangent.
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Well, look, I think games have been significant in my life
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for three reasons.
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So first of all, I was playing them
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and training myself on games when I was a kid.
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Then I went through a phase of designing games
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and writing AI for games.
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So all the games I professionally wrote
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had AI as a core component.
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And that was mostly in the 90s.
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And the reason I was doing that in games industry
link |
00:14:42.960
was at the time the games industry,
link |
00:14:45.080
I think was the cutting edge of technology.
link |
00:14:47.160
So whether it was graphics with people like John Carmack
link |
00:14:49.800
and Quake and those kinds of things or AI,
link |
00:14:53.040
I think actually all the action was going on in games.
link |
00:14:56.160
And we're still reaping the benefits of that
link |
00:14:58.440
even with things like GPUs, which I find ironic
link |
00:15:01.480
was obviously invented for graphics, computer graphics,
link |
00:15:03.680
but then turns out to be amazingly useful for AI.
link |
00:15:06.320
It just turns out everything's a matrix multiplication
link |
00:15:08.760
it appears in the whole world.
link |
00:15:11.080
So I think games at the time had the most cutting edge AI.
link |
00:15:15.800
And a lot of the games, I was involved in writing.
link |
00:15:19.800
So there was a game called Black and White,
link |
00:15:21.280
which was one game I was involved with
link |
00:15:22.760
in the early stages of,
link |
00:15:24.000
which I still think is the most impressive example
link |
00:15:28.400
of reinforcement learning in a computer game.
link |
00:15:30.560
So in that game, you trained a little pet animal and...
link |
00:15:34.600
It's a brilliant game.
link |
00:15:35.440
And it sort of learned from how you were treating it.
link |
00:15:37.640
So if you treated it badly, then it became mean.
link |
00:15:40.680
And then it would be mean to your villagers
link |
00:15:42.920
and your population, the sort of the little tribe
link |
00:15:45.760
that you were running.
link |
00:15:47.240
But if you were kind to it, then it would be kind.
link |
00:15:49.400
And people were fascinated by how that works.
link |
00:15:51.080
And so was I to be honest with the way it kind of developed.
link |
00:15:54.160
And...
link |
00:15:55.120
Especially the mapping to good and evil.
link |
00:15:57.240
Yeah.
link |
00:15:58.080
Made you realize, made me realize that you can sort of
link |
00:16:01.640
in the choices you make can define where you end up.
link |
00:16:07.440
And that means all of us are capable of the good, evil.
link |
00:16:12.640
It all matters in the different choices
link |
00:16:15.240
along the trajectory to those places that you make.
link |
00:16:18.240
It's fascinating.
link |
00:16:19.080
I mean, games can do that philosophically to you.
link |
00:16:21.360
And it's rare.
link |
00:16:22.200
It seems rare.
link |
00:16:23.040
Yeah.
link |
00:16:23.880
Well, games are, I think, a unique medium
link |
00:16:24.720
because you as the player,
link |
00:16:26.600
you're not just passively consuming the entertainment,
link |
00:16:30.080
right?
link |
00:16:30.920
You're actually actively involved as an agent.
link |
00:16:34.280
So I think that's what makes it in some ways
link |
00:16:36.160
can be more visceral than other mediums
link |
00:16:38.400
like films and books.
link |
00:16:40.000
So the second, so that was designing AI in games.
link |
00:16:42.640
And then the third use we've used of AI
link |
00:16:46.440
is in DeepMind from the beginning,
link |
00:16:48.440
which is using games as a testing ground
link |
00:16:50.920
for proving out AI algorithms and developing AI algorithms.
link |
00:16:55.000
And that was a sort of a core component
link |
00:16:58.480
of our vision at the start of DeepMind
link |
00:17:00.320
was that we would use games very heavily
link |
00:17:03.200
as our main testing ground, certainly to begin with,
link |
00:17:06.360
because it's super efficient to use games.
link |
00:17:08.560
And also, it's very easy to have metrics
link |
00:17:11.480
to see how well your systems are improving
link |
00:17:14.080
and what direction your ideas are going in
link |
00:17:15.840
and whether you're making incremental improvements.
link |
00:17:18.400
And because those games are often rooted
link |
00:17:20.400
in something that humans did for a long time beforehand,
link |
00:17:23.360
there's already a strong set of rules.
link |
00:17:26.520
Like it's already a damn good benchmark.
link |
00:17:28.240
Yes, it's really good for so many reasons
link |
00:17:30.200
because you've got clear measures
link |
00:17:32.800
of how good humans can be at these things.
link |
00:17:35.520
And in some cases like Go,
link |
00:17:36.840
we've been playing it for thousands of years
link |
00:17:39.720
and often they have scores or at least win conditions.
link |
00:17:43.280
So it's very easy for reward learning systems
link |
00:17:45.640
to get a reward.
link |
00:17:46.480
It's very easy to specify what that reward is.
link |
00:17:49.320
And also at the end, it's easy to test externally
link |
00:17:54.320
at how strong is your system by of course,
link |
00:17:56.920
playing against the world's strongest players at those games.
link |
00:18:00.240
So it's so good for so many reasons
link |
00:18:02.680
and it's also very efficient to run potentially millions
link |
00:18:05.520
of simulations in parallel on the cloud.
link |
00:18:08.280
So I think there's a huge reason why we were so successful
link |
00:18:12.800
back in starting out 2010,
link |
00:18:14.760
how come we were able to progress so quickly
link |
00:18:16.680
because we've utilized games.
link |
00:18:18.880
And at the beginning of DeepMind,
link |
00:18:21.320
we also hired some amazing game engineers
link |
00:18:24.600
who I knew from my previous lives in the games industry.
link |
00:18:28.000
And that helped to bootstrap us very quickly.
link |
00:18:30.920
And plus it's somehow super compelling
link |
00:18:33.880
almost at a philosophical level of man versus machine
link |
00:18:38.080
over a chess board or a Go board.
link |
00:18:41.200
And especially given that the entire history of AI
link |
00:18:43.600
is defined by people saying it's gonna be impossible
link |
00:18:45.960
to make a machine that beats a human being in chess.
link |
00:18:50.960
And then once that happened,
link |
00:18:53.200
people were certain when I was coming up in AI
link |
00:18:55.880
that Go is not a game that can be solved
link |
00:18:58.760
because of the combinatorial complexity is just too,
link |
00:19:02.000
it's no matter how much Moore's law you have,
link |
00:19:06.640
compute is just never going to be able
link |
00:19:08.560
to crack the game of Go.
link |
00:19:10.200
And so then there's something compelling about facing,
link |
00:19:14.920
sort of taking on the impossibility of that task
link |
00:19:18.160
from the AI researcher perspective,
link |
00:19:22.480
engineer perspective, and then as a human being,
link |
00:19:24.520
just observing this whole thing.
link |
00:19:27.040
Your beliefs about what you thought was impossible
link |
00:19:32.520
being broken apart,
link |
00:19:35.920
it's humbling to realize we're not as smart as we thought.
link |
00:19:40.480
It's humbling to realize that the things we think
link |
00:19:43.160
are impossible now perhaps will be done in the future.
link |
00:19:47.000
There's something really powerful about a game,
link |
00:19:50.800
AI system beating human being in a game
link |
00:19:52.880
that drives that message home
link |
00:19:55.680
for like millions, billions of people,
link |
00:19:58.000
especially in the case of Go.
link |
00:19:59.320
Sure.
link |
00:20:00.520
Well, look, I think it's,
link |
00:20:01.640
I mean, it has been a fascinating journey
link |
00:20:03.720
and especially as I think about it from,
link |
00:20:06.880
I can understand it from both sides,
link |
00:20:08.760
both as the AI, creators of the AI,
link |
00:20:13.080
but also as a games player originally.
link |
00:20:15.640
So, it was a really interesting,
link |
00:20:17.960
I mean, it was a fantastic, but also somewhat
link |
00:20:21.160
bittersweet moment, the AlphaGo match for me,
link |
00:20:24.680
seeing that and being obviously heavily involved in that.
link |
00:20:29.440
But as you say, chess has been the,
link |
00:20:32.480
I mean, Kasparov, I think rightly called it
link |
00:20:34.360
the Drosophila of intelligence, right?
link |
00:20:37.280
So, it's sort of, I love that phrase
link |
00:20:39.520
and I think he's right because chess has been
link |
00:20:42.960
hand in hand with AI from the beginning
link |
00:20:45.360
of the whole field, right?
link |
00:20:47.440
So, I think every AI practitioner,
link |
00:20:49.640
starting with Turing and Claude Shannon and all those,
link |
00:20:52.480
the sort of forefathers of the field,
link |
00:20:56.320
tried their hand at writing a chess program.
link |
00:20:58.840
I've got original edition of Claude Shannon's
link |
00:21:01.160
first chess program, I think it was 1949,
link |
00:21:04.000
the original sort of paper.
link |
00:21:06.760
And they all did that and Turing famously wrote
link |
00:21:09.960
a chess program, but all the computers around them
link |
00:21:12.480
were obviously too slow to run it.
link |
00:21:13.760
So, he had to run, he had to be the computer, right?
link |
00:21:16.040
So, he literally, I think spent two or three days
link |
00:21:18.920
running his own program by hand with pencil and paper
link |
00:21:21.360
and playing a friend of his with his chess program.
link |
00:21:24.960
So, of course, Deep Blue was a huge moment,
link |
00:21:28.560
beating Kasparov, but actually when that happened,
link |
00:21:31.880
I remember that very vividly, of course,
link |
00:21:34.120
because it was chess and computers and AI,
link |
00:21:36.640
all the things I loved and I was at college at the time.
link |
00:21:39.240
But I remember coming away from that,
link |
00:21:40.800
being more impressed by Kasparov's mind
link |
00:21:43.080
than I was by Deep Blue.
link |
00:21:44.480
Because here was Kasparov with his human mind,
link |
00:21:47.680
not only could he play chess more or less
link |
00:21:49.400
to the same level as this brute of a calculation machine,
link |
00:21:53.160
but of course, Kasparov can do everything else
link |
00:21:55.160
humans can do, ride a bike, talk many languages,
link |
00:21:57.480
do politics, all the rest of the amazing things
link |
00:21:59.400
that Kasparov does.
link |
00:22:00.880
And so, with the same brain.
link |
00:22:03.160
And yet Deep Blue, brilliant as it was at chess,
link |
00:22:07.040
it'd been hand coded for chess and actually had distilled
link |
00:22:12.040
the knowledge of chess grandmasters into a cool program,
link |
00:22:16.400
but it couldn't do anything else.
link |
00:22:18.000
It couldn't even play a strictly simpler game
link |
00:22:20.080
like tic tac toe.
link |
00:22:21.280
So, something to me was missing from intelligence
link |
00:22:25.880
from that system that we would regard as intelligence.
link |
00:22:28.480
And I think it was this idea of generality
link |
00:22:30.880
and also learning.
link |
00:22:33.000
So, and that's obviously what we tried to do with AlphaGo.
link |
00:22:36.120
Yeah, with AlphaGo and AlphaZero, MuZero,
link |
00:22:38.600
and then God and all the things that we'll get into
link |
00:22:42.040
some parts of, there's just a fascinating trajectory here.
link |
00:22:45.640
But let's just stick on chess briefly.
link |
00:22:48.520
On the human side of chess, you've proposed that
link |
00:22:51.960
from a game design perspective,
link |
00:22:53.400
the thing that makes chess compelling as a game
link |
00:22:57.760
is that there's a creative tension between a bishop
link |
00:23:01.000
and the knight.
link |
00:23:02.960
Can you explain this?
link |
00:23:04.040
First of all, it's really interesting to think about
link |
00:23:06.440
what makes a game compelling,
link |
00:23:08.640
makes it stick across centuries.
link |
00:23:12.000
Yeah, I was sort of thinking about this,
link |
00:23:13.480
and actually a lot of even amazing chess players
link |
00:23:15.440
don't think about it necessarily
link |
00:23:16.840
from a game's designer point of view.
link |
00:23:18.280
So, it's with my game design hat on
link |
00:23:20.240
that I was thinking about this, why is chess so compelling?
link |
00:23:23.080
And I think a critical reason is the dynamicness
link |
00:23:27.560
of the different kind of chess positions you can have,
link |
00:23:30.000
whether they're closed or open and other things,
link |
00:23:32.200
comes from the bishop and the knight.
link |
00:23:33.520
So, if you think about how different
link |
00:23:36.480
the capabilities of the bishop and knight are
link |
00:23:39.240
in terms of the way they move,
link |
00:23:40.880
and then somehow chess has evolved
link |
00:23:43.080
to balance those two capabilities more or less equally.
link |
00:23:46.080
So, they're both roughly worth three points each.
link |
00:23:48.720
So, you think that dynamics is always there
link |
00:23:50.560
and then the rest of the rules
link |
00:23:51.640
are kind of trying to stabilize the game.
link |
00:23:53.760
Well, maybe, I mean, it's sort of,
link |
00:23:55.080
I don't know, it's chicken and egg situation,
link |
00:23:56.560
probably both came together.
link |
00:23:57.680
But the fact that it's got to this beautiful equilibrium
link |
00:24:00.520
where you can have the bishop and knight
link |
00:24:02.360
that are so different in power,
link |
00:24:04.400
but so equal in value across the set
link |
00:24:06.920
of the universe of all positions, right?
link |
00:24:09.480
Somehow they've been balanced by humanity
link |
00:24:11.560
over hundreds of years,
link |
00:24:13.480
I think gives the game the creative tension
link |
00:24:16.880
that you can swap the bishop and knights
link |
00:24:19.000
for a bishop for a knight,
link |
00:24:20.160
and they're more or less worth the same,
link |
00:24:22.080
but now you aim for a different type of position.
link |
00:24:24.040
If you have the knight, you want a closed position.
link |
00:24:26.040
If you have the bishop, you want an open position.
link |
00:24:28.160
So, I think that creates
link |
00:24:29.000
a lot of the creative tension in chess.
link |
00:24:30.920
So, some kind of controlled creative tension.
link |
00:24:34.040
From an AI perspective,
link |
00:24:35.960
do you think AI systems could eventually design games
link |
00:24:38.840
that are optimally compelling to humans?
link |
00:24:41.640
Well, that's an interesting question.
link |
00:24:42.920
Sometimes I get asked about AI and creativity,
link |
00:24:46.000
and the way I answered that is relevant to that question,
link |
00:24:48.880
which is that I think there are different levels
link |
00:24:51.240
of creativity, one could say.
link |
00:24:52.920
So, I think if we define creativity
link |
00:24:55.320
as coming up with something original, right,
link |
00:24:57.280
that's useful for a purpose,
link |
00:24:59.320
then I think the kind of lowest level of creativity
link |
00:25:02.240
is like an interpolation.
link |
00:25:03.720
So, an averaging of all the examples you see.
link |
00:25:06.280
So, maybe a very basic AI system could say
link |
00:25:08.320
you could have that.
link |
00:25:09.160
So, you show it millions of pictures of cats,
link |
00:25:11.400
and then you say, give me an average looking cat, right?
link |
00:25:13.920
Generate me an average looking cat.
link |
00:25:15.480
I would call that interpolation.
link |
00:25:17.200
Then there's extrapolation,
link |
00:25:18.720
which something like AlphaGo showed.
link |
00:25:20.440
So, AlphaGo played millions of games of Go against itself,
link |
00:25:24.320
and then it came up with brilliant new ideas
link |
00:25:26.600
like Move 37 in game two, brilliant motif strategies in Go
link |
00:25:30.760
that no humans had ever thought of,
link |
00:25:32.840
even though we've played it for thousands of years
link |
00:25:34.800
and professionally for hundreds of years.
link |
00:25:36.600
So, that I call that extrapolation,
link |
00:25:38.840
but then there's still a level above that,
link |
00:25:41.080
which is, you could call out of the box thinking
link |
00:25:44.000
or true innovation, which is, could you invent Go, right?
link |
00:25:47.520
Could you invent chess and not just come up
link |
00:25:49.200
with a brilliant chess move or brilliant Go move,
link |
00:25:51.320
but can you actually invent chess
link |
00:25:53.680
or something as good as chess or Go?
link |
00:25:55.880
And I think one day AI could, but then what's missing
link |
00:26:00.080
is how would you even specify that task
link |
00:26:02.240
to a program right now?
link |
00:26:04.440
And the way I would do it if I was telling a human to do it
link |
00:26:07.560
or a human games designer to do it is I would say,
link |
00:26:10.800
something like Go, I would say, come up with a game
link |
00:26:14.120
that only takes five minutes to learn,
link |
00:26:16.080
which Go does because it's got simple rules,
link |
00:26:17.880
but many lifetimes to master, right?
link |
00:26:20.280
Or impossible to master in one lifetime
link |
00:26:22.080
because it's so deep and so complex.
link |
00:26:23.920
And then it's aesthetically beautiful.
link |
00:26:26.520
And also it can be completed in three or four hours
link |
00:26:30.080
of gameplay time, which is useful for us in a human day.
link |
00:26:35.280
And so you might specify these sort of high level concepts
link |
00:26:38.560
like that, and then with that
link |
00:26:40.640
and then maybe a few other things,
link |
00:26:42.800
one could imagine that Go satisfies those constraints.
link |
00:26:47.560
But the problem is that we're not able
link |
00:26:49.600
to specify abstract notions like that,
link |
00:26:53.040
high level abstract notions like that yet to our AI systems.
link |
00:26:57.040
And I think there's still something missing there
link |
00:26:58.840
in terms of high level concepts or abstractions
link |
00:27:01.840
that they truly understand
link |
00:27:03.080
and they're combinable and compositional.
link |
00:27:06.560
So for the moment, I think AI is capable
link |
00:27:09.760
of doing interpolation and extrapolation,
link |
00:27:11.760
but not true invention.
link |
00:27:13.520
So coming up with rule sets and optimizing
link |
00:27:18.040
with complicated objectives around those rule sets,
link |
00:27:20.640
we can't currently do.
link |
00:27:22.280
But you could take a specific rule set
link |
00:27:25.480
and then run a kind of self play experiment
link |
00:27:28.360
to see how long, just observe how an AI system
link |
00:27:32.040
from scratch learns, how long is that journey of learning?
link |
00:27:35.960
And maybe if it satisfies some of those other things
link |
00:27:39.160
you mentioned in terms of quickness to learn and so on,
link |
00:27:41.680
and you could see a long journey to master
link |
00:27:44.200
for even an AI system, then you could say
link |
00:27:46.920
that this is a promising game.
link |
00:27:49.280
But it would be nice to do almost like AlphaCode
link |
00:27:51.720
so programming rules.
link |
00:27:53.960
So generating rules that automate even that part
link |
00:27:59.000
of the generation of rules.
link |
00:28:00.440
So I have thought about systems actually
link |
00:28:02.960
that I think would be amazing for a games designer.
link |
00:28:05.680
If you could have a system that takes your game,
link |
00:28:09.200
plays it tens of millions of times, maybe overnight,
link |
00:28:11.960
and then self balances the rules better.
link |
00:28:13.840
So it tweaks the rules and maybe the equations
link |
00:28:18.080
and the parameters so that the game is more balanced,
link |
00:28:22.680
the units in the game or some of the rules could be tweaked.
link |
00:28:26.280
So it's a bit of like giving a base set
link |
00:28:28.320
and then allowing Monte Carlo Tree Search
link |
00:28:30.800
or something like that to sort of explore it.
link |
00:28:33.360
And I think that would be super powerful tool actually
link |
00:28:37.080
for balancing, auto balancing a game,
link |
00:28:39.720
which usually takes thousands of hours
link |
00:28:42.120
from hundreds of human games testers normally
link |
00:28:44.520
to balance a game like StarCraft,
link |
00:28:47.480
which is Blizzard are amazing at balancing their games,
link |
00:28:50.640
but it takes them years and years and years.
link |
00:28:52.600
So one could imagine at some point
link |
00:28:54.120
when this stuff becomes efficient enough
link |
00:28:57.080
to you might be able to do that like overnight.
link |
00:28:59.560
Do you think a game that is optimal designed by an AI system
link |
00:29:05.000
would look very much like a planet earth?
link |
00:29:09.640
Maybe, maybe it's only the sort of game
link |
00:29:11.640
I would love to make is, and I've tried in my games career,
link |
00:29:16.040
the games design career, my first big game
link |
00:29:18.560
was designing a theme park, an amusement park.
link |
00:29:21.440
Then with games like Republic, I tried to have games
link |
00:29:25.200
where we designed whole cities and allowed you to play in.
link |
00:29:28.480
So, and of course people like Will Wright
link |
00:29:30.320
have written games like SimEarth,
link |
00:29:32.640
trying to simulate the whole of earth, pretty tricky,
link |
00:29:35.200
but I think.
link |
00:29:36.040
SimEarth, I haven't actually played that one.
link |
00:29:37.600
So what is it?
link |
00:29:38.440
Does it incorporate of evolution or?
link |
00:29:40.320
Yeah, it has evolution and it sort of tries to,
link |
00:29:43.280
it sort of treats it as an entire biosphere,
link |
00:29:45.320
but from quite high level.
link |
00:29:47.240
So.
link |
00:29:48.080
It'd be nice to be able to sort of zoom in,
link |
00:29:50.280
zoom out and zoom in.
link |
00:29:51.320
Exactly, exactly.
link |
00:29:52.160
So obviously it couldn't do, that was in the 90s.
link |
00:29:53.440
I think he wrote that in the 90s.
link |
00:29:54.920
So it couldn't, it wasn't able to do that,
link |
00:29:57.560
but that would be obviously the ultimate sandbox game.
link |
00:30:00.520
Of course.
link |
00:30:01.480
On that topic, do you think we're living in a simulation?
link |
00:30:04.760
Yes, well, so, okay.
link |
00:30:06.160
So I.
link |
00:30:07.000
We're gonna jump around from the absurdly philosophical
link |
00:30:09.280
to the technical.
link |
00:30:10.120
Sure, sure, very, very happy to.
link |
00:30:11.880
So I think my answer to that question
link |
00:30:13.800
is a little bit complex because there is simulation theory,
link |
00:30:17.640
which obviously Nick Bostrom,
link |
00:30:18.800
I think famously first proposed.
link |
00:30:21.680
And I don't quite believe it in that sense.
link |
00:30:24.720
So in the sense that are we in some sort of computer game
link |
00:30:29.600
or have our descendants somehow recreated earth
link |
00:30:34.000
in the 21st century and some,
link |
00:30:36.520
for some kind of experimental reason.
link |
00:30:38.480
I think that, but I do think that we,
link |
00:30:41.880
that we might be, that the best way to understand physics
link |
00:30:45.600
and the universe is from a computational perspective.
link |
00:30:49.320
So understanding it as an information universe
link |
00:30:52.440
and actually information being the most fundamental unit
link |
00:30:56.200
of reality rather than matter or energy.
link |
00:30:59.920
So a physicist would say, you know, matter or energy,
link |
00:31:02.400
you know, E equals MC squared.
link |
00:31:03.760
These are the things that are the fundamentals
link |
00:31:06.440
of the universe.
link |
00:31:07.400
I'd actually say information,
link |
00:31:09.880
which of course itself can be,
link |
00:31:11.760
can specify energy or matter, right?
link |
00:31:13.560
Matter is actually just, you know,
link |
00:31:14.920
we're just out the way our bodies
link |
00:31:16.880
and the molecules in our body are arranged as information.
link |
00:31:19.720
So I think information may be the most fundamental way
link |
00:31:23.080
to describe the universe.
link |
00:31:24.960
And therefore you could say we're in some sort of simulation
link |
00:31:28.280
because of that.
link |
00:31:29.880
But I don't, I do, I'm not,
link |
00:31:31.040
I'm not really a subscriber to the idea that, you know,
link |
00:31:34.200
these are sort of throw away billions of simulations around.
link |
00:31:36.920
I think this is actually very critical and possibly unique,
link |
00:31:40.640
this simulation.
link |
00:31:41.760
This particular one.
link |
00:31:42.600
Yes.
link |
00:31:43.440
And you just mean treating the universe as a computer
link |
00:31:48.760
that's processing and modifying information
link |
00:31:52.240
is a good way to solve the problems of physics,
link |
00:31:54.880
of chemistry, of biology,
link |
00:31:57.160
and perhaps of humanity and so on.
link |
00:31:59.720
Yes, I think understanding physics
link |
00:32:02.240
in terms of information theory
link |
00:32:04.840
might be the best way to really understand
link |
00:32:07.880
what's going on here.
link |
00:32:09.360
From our understanding of a universal Turing machine,
link |
00:32:13.560
from our understanding of a computer,
link |
00:32:15.280
do you think there's something outside
link |
00:32:17.400
of the capabilities of a computer
link |
00:32:19.440
that is present in our universe?
link |
00:32:21.000
You have a disagreement with Roger Penrose
link |
00:32:23.560
about the nature of consciousness.
link |
00:32:25.920
He thinks that consciousness is more
link |
00:32:27.760
than just a computation.
link |
00:32:30.080
Do you think all of it, the whole shebangs,
link |
00:32:32.680
can be a computation?
link |
00:32:34.000
Yeah, I've had many fascinating debates
link |
00:32:35.840
with Sir Roger Penrose,
link |
00:32:37.680
and obviously he's famously,
link |
00:32:39.680
and I read, you know, Emperors of the New Mind
link |
00:32:41.520
and his books, his classical books,
link |
00:32:45.400
and they were pretty influential in the 90s.
link |
00:32:47.800
And he believes that there's something more,
link |
00:32:50.960
something quantum that is needed
link |
00:32:53.040
to explain consciousness in the brain.
link |
00:32:55.840
I think about what we're doing actually at DeepMind
link |
00:32:58.320
and what my career is being,
link |
00:32:59.920
we're almost like Turing's champion.
link |
00:33:01.920
So we are pushing Turing machines or classical computation
link |
00:33:05.360
to the limits.
link |
00:33:06.200
What are the limits of what classical computing can do?
link |
00:33:09.440
Now, and at the same time,
link |
00:33:11.760
I've also studied neuroscience to see,
link |
00:33:14.240
and that's why I did my PhD in,
link |
00:33:15.520
was to see, also to look at, you know,
link |
00:33:17.720
is there anything quantum in the brain
link |
00:33:19.240
from a neuroscience or biological perspective?
link |
00:33:21.360
And so far, I think most neuroscientists
link |
00:33:24.560
and most mainstream biologists and neuroscientists
link |
00:33:26.440
would say there's no evidence of any quantum systems
link |
00:33:29.480
or effects in the brain.
link |
00:33:30.800
As far as we can see, it can be mostly explained
link |
00:33:33.000
by classical theories.
link |
00:33:35.880
So, and then, so there's sort of the search
link |
00:33:39.280
from the biology side.
link |
00:33:40.600
And then at the same time,
link |
00:33:42.120
there's the raising of the water, the bar,
link |
00:33:44.960
from what classical Turing machines can do.
link |
00:33:48.240
And, you know, including our new AI systems.
link |
00:33:51.680
And as you alluded to earlier, you know,
link |
00:33:55.040
I think AI, especially in the last decade plus,
link |
00:33:57.760
has been a continual story now of surprising events
link |
00:34:02.360
and surprising successes,
link |
00:34:03.920
knocking over one theory after another
link |
00:34:05.800
of what was thought to be impossible, you know,
link |
00:34:07.760
from Go to protein folding and so on.
link |
00:34:10.080
And so I think I would be very hesitant
link |
00:34:14.760
to bet against how far the universal Turing machine
link |
00:34:19.520
and classical computation paradigm can go.
link |
00:34:23.400
And my betting would be that all of,
link |
00:34:26.720
certainly what's going on in our brain,
link |
00:34:29.080
can probably be mimicked or approximated
link |
00:34:32.160
on a classical machine,
link |
00:34:34.720
not requiring something metaphysical or quantum.
link |
00:34:38.400
And we'll get there with some of the work with AlphaFold,
link |
00:34:41.720
which I think begins the journey of modeling
link |
00:34:45.080
this beautiful and complex world of biology.
link |
00:34:48.160
So you think all the magic of the human mind
link |
00:34:50.160
comes from this, just a few pounds of mush,
link |
00:34:54.280
of biological computational mush,
link |
00:34:57.480
that's akin to some of the neural networks,
link |
00:35:01.560
not directly, but in spirit
link |
00:35:03.800
that DeepMind has been working with.
link |
00:35:06.200
Well, look, I think it's, you say it's a few, you know,
link |
00:35:08.680
of course it's, this is the,
link |
00:35:09.680
I think the biggest miracle of the universe
link |
00:35:11.520
is that it is just a few pounds of mush in our skulls.
link |
00:35:15.000
And yet it's also our brains are the most complex objects
link |
00:35:18.560
that we know of in the universe.
link |
00:35:20.240
So there's something profoundly beautiful
link |
00:35:22.360
and amazing about our brains.
link |
00:35:23.920
And I think that it's an incredibly,
link |
00:35:28.640
incredible efficient machine.
link |
00:35:30.720
And it's, you know, phenomenon basically.
link |
00:35:35.520
And I think that building AI,
link |
00:35:37.480
one of the reasons I wanna build AI,
link |
00:35:38.920
and I've always wanted to is,
link |
00:35:40.440
I think by building an intelligent artifact like AI,
link |
00:35:43.800
and then comparing it to the human mind,
link |
00:35:46.480
that will help us unlock the uniqueness
link |
00:35:49.560
and the true secrets of the mind
link |
00:35:50.960
that we've always wondered about since the dawn of history,
link |
00:35:53.480
like consciousness, dreaming, creativity, emotions,
link |
00:35:59.160
what are all these things, right?
link |
00:36:00.760
We've wondered about them since the dawn of humanity.
link |
00:36:04.200
And I think one of the reasons,
link |
00:36:05.920
and, you know, I love philosophy and philosophy of mind is,
link |
00:36:08.760
we found it difficult is there haven't been the tools
link |
00:36:11.200
for us to really, other than introspection,
link |
00:36:13.680
from very clever people in history,
link |
00:36:15.880
very clever philosophers,
link |
00:36:17.200
to really investigate this scientifically.
link |
00:36:19.360
But now suddenly we have a plethora of tools.
link |
00:36:21.720
Firstly, we have all of the neuroscience tools,
link |
00:36:23.240
fMRI machines, single cell recording, all of this stuff,
link |
00:36:25.920
but we also have the ability, computers and AI,
link |
00:36:29.000
to build intelligent systems.
link |
00:36:31.640
So I think that, you know,
link |
00:36:34.720
I think it is amazing what the human mind does.
link |
00:36:37.320
And I'm kind of in awe of it really.
link |
00:36:41.120
And I think it's amazing that with our human minds,
link |
00:36:44.440
we're able to build things like computers
link |
00:36:46.760
and actually even, you know,
link |
00:36:48.280
think and investigate about these questions.
link |
00:36:49.880
I think that's also a testament to the human mind.
link |
00:36:52.720
Yeah.
link |
00:36:53.560
The universe built the human mind
link |
00:36:56.200
that now is building computers that help us understand
link |
00:36:59.600
both the universe and our own human mind.
link |
00:37:01.480
That's right.
link |
00:37:02.320
This is actually it.
link |
00:37:03.140
I mean, I think that's one, you know,
link |
00:37:03.980
one could say we are,
link |
00:37:05.760
maybe we're the mechanism by which the universe
link |
00:37:08.160
is going to try and understand itself.
link |
00:37:09.840
Yeah.
link |
00:37:10.680
It's beautiful.
link |
00:37:13.160
So let's go to the basic building blocks of biology
link |
00:37:16.960
that I think is another angle at which you can start
link |
00:37:20.200
to understand the human mind, the human body,
link |
00:37:22.280
which is quite fascinating,
link |
00:37:23.400
which is from the basic building blocks,
link |
00:37:26.640
start to simulate, start to model
link |
00:37:28.960
how from those building blocks,
link |
00:37:30.480
you can construct bigger and bigger, more complex systems,
link |
00:37:33.080
maybe one day the entirety of the human biology.
link |
00:37:35.820
So here's another problem that thought
link |
00:37:39.680
to be impossible to solve, which is protein folding.
link |
00:37:42.720
And Alpha Fold or specifically Alpha Fold 2 did just that.
link |
00:37:48.840
It solved protein folding.
link |
00:37:50.320
I think it's one of the biggest breakthroughs,
link |
00:37:53.400
certainly in the history of structural biology,
link |
00:37:55.140
but in general in science,
link |
00:38:00.240
maybe from a high level, what is it and how does it work?
link |
00:38:04.840
And then we can ask some fascinating questions after.
link |
00:38:08.700
Sure.
link |
00:38:09.980
So maybe to explain it to people not familiar
link |
00:38:12.880
with protein folding is, you know,
link |
00:38:14.400
first of all, explain proteins, which is, you know,
link |
00:38:16.980
proteins are essential to all life.
link |
00:38:18.840
Every function in your body depends on proteins.
link |
00:38:21.520
Sometimes they're called the workhorses of biology.
link |
00:38:23.920
And if you look into them and I've, you know,
link |
00:38:25.340
obviously as part of Alpha Fold,
link |
00:38:26.660
I've been researching proteins and structural biology
link |
00:38:30.200
for the last few years, you know,
link |
00:38:31.760
they're amazing little bio nano machines proteins.
link |
00:38:34.760
They're incredible if you actually watch little videos
link |
00:38:36.460
of how they work, animations of how they work.
link |
00:38:39.000
And proteins are specified by their genetic sequence
link |
00:38:42.600
called the amino acid sequence.
link |
00:38:44.280
So you can think of it as their genetic makeup.
link |
00:38:47.040
And then in the body in nature,
link |
00:38:50.080
they fold up into a 3D structure.
link |
00:38:53.360
So you can think of it as a string of beads
link |
00:38:55.320
and then they fold up into a ball.
link |
00:38:57.160
Now, the key thing is you want to know
link |
00:38:59.100
what that 3D structure is because the structure,
link |
00:39:02.480
the 3D structure of a protein is what helps to determine
link |
00:39:06.120
what does it do, the function it does in your body.
link |
00:39:08.580
And also if you're interested in drugs or disease,
link |
00:39:12.320
you need to understand that 3D structure
link |
00:39:13.980
because if you want to target something
link |
00:39:15.840
with a drug compound about to block something
link |
00:39:18.640
the protein's doing, you need to understand
link |
00:39:21.120
where it's gonna bind on the surface of the protein.
link |
00:39:23.440
So obviously in order to do that,
link |
00:39:24.940
you need to understand the 3D structure.
link |
00:39:26.720
So the structure is mapped to the function.
link |
00:39:28.640
The structure is mapped to the function
link |
00:39:29.880
and the structure is obviously somehow specified
link |
00:39:32.560
by the amino acid sequence.
link |
00:39:34.840
And that's the, in essence, the protein folding problem is,
link |
00:39:37.420
can you just from the amino acid sequence,
link |
00:39:39.620
the one dimensional string of letters,
link |
00:39:42.560
can you immediately computationally predict
link |
00:39:45.600
the 3D structure?
link |
00:39:47.120
And this has been a grand challenge in biology
link |
00:39:50.020
for over 50 years.
link |
00:39:51.500
So I think it was first articulated by Christian Anfinsen,
link |
00:39:54.360
a Nobel prize winner in 1972,
link |
00:39:57.040
as part of his Nobel prize winning lecture.
link |
00:39:59.240
And he just speculated this should be possible
link |
00:40:01.860
to go from the amino acid sequence to the 3D structure,
link |
00:40:04.960
but he didn't say how.
link |
00:40:06.060
So it's been described to me as equivalent
link |
00:40:09.440
to Fermat's last theorem, but for biology.
link |
00:40:12.320
You should, as somebody that very well might win
link |
00:40:15.120
the Nobel prize in the future.
link |
00:40:16.560
But outside of that, you should do more
link |
00:40:19.240
of that kind of thing.
link |
00:40:20.080
In the margin, just put random things
link |
00:40:22.160
that will take like 200 years to solve.
link |
00:40:24.440
Set people off for 200 years.
link |
00:40:26.000
It should be possible.
link |
00:40:27.720
And just don't give any details.
link |
00:40:29.040
Exactly.
link |
00:40:29.880
I think everyone exactly should be,
link |
00:40:31.500
I'll have to remember that for future.
link |
00:40:33.520
So yeah, so he set off, you know,
link |
00:40:34.800
with this one throwaway remark, just like Fermat,
link |
00:40:37.040
you know, he set off this whole 50 year field really
link |
00:40:42.640
of computational biology.
link |
00:40:44.400
And they had, you know, they got stuck.
link |
00:40:46.240
They hadn't really got very far with doing this.
link |
00:40:48.520
And until now, until AlphaFold came along,
link |
00:40:52.500
this is done experimentally, right?
link |
00:40:54.320
Very painstakingly.
link |
00:40:55.500
So the rule of thumb is, and you have to like
link |
00:40:57.440
crystallize the protein, which is really difficult.
link |
00:40:59.820
Some proteins can't be crystallized like membrane proteins.
link |
00:41:03.060
And then you have to use very expensive electron microscopes
link |
00:41:05.940
or X ray crystallography machines.
link |
00:41:08.200
Really painstaking work to get the 3D structure
link |
00:41:10.680
and visualize the 3D structure.
link |
00:41:12.400
So the rule of thumb in experimental biology
link |
00:41:14.840
is that it takes one PhD student,
link |
00:41:16.860
their entire PhD to do one protein.
link |
00:41:20.320
And with AlphaFold 2, we were able to predict
link |
00:41:23.440
the 3D structure in a matter of seconds.
link |
00:41:26.400
And so we were, you know, over Christmas,
link |
00:41:28.700
we did the whole human proteome
link |
00:41:30.240
or every protein in the human body or 20,000 proteins.
link |
00:41:33.280
So the human proteomes like the equivalent
link |
00:41:34.760
of the human genome, but on protein space.
link |
00:41:37.560
And sort of revolutionized really
link |
00:41:40.240
what a structural biologist can do.
link |
00:41:43.300
Because now they don't have to worry
link |
00:41:45.720
about these painstaking experimental,
link |
00:41:47.960
should they put all of that effort in or not?
link |
00:41:49.560
They can almost just look up the structure
link |
00:41:51.120
of their proteins like a Google search.
link |
00:41:53.280
And so there's a data set on which it's trained
link |
00:41:56.880
and how to map this amino acid sequence.
link |
00:41:58.800
First of all, it's incredible that a protein,
link |
00:42:00.760
this little chemical computer is able to do
link |
00:42:02.480
that computation itself in some kind of distributed way
link |
00:42:05.720
and do it very quickly.
link |
00:42:07.800
That's a weird thing.
link |
00:42:08.840
And they evolve that way because, you know,
link |
00:42:10.480
in the beginning, I mean, that's a great invention,
link |
00:42:13.200
just the protein itself.
link |
00:42:14.760
And then there's, I think, probably a history
link |
00:42:18.240
of like they evolved to have many of these proteins
link |
00:42:22.740
and those proteins figure out how to be computers themselves
link |
00:42:26.600
in such a way that you can create structures
link |
00:42:28.560
that can interact in complexes with each other
link |
00:42:30.540
in order to form high level functions.
link |
00:42:32.660
I mean, it's a weird system that they figured it out.
link |
00:42:35.520
Well, for sure.
link |
00:42:36.360
I mean, you know, maybe we should talk
link |
00:42:37.640
about the origins of life too,
link |
00:42:39.000
but proteins themselves, I think are magical
link |
00:42:41.180
and incredible, as I said, little bio nano machines.
link |
00:42:45.760
And actually Leventhal, who was another scientist,
link |
00:42:50.280
a contemporary of Amphinson, he coined this Leventhal,
link |
00:42:55.120
what became known as Leventhal's paradox,
link |
00:42:56.820
which is exactly what you're saying.
link |
00:42:58.320
He calculated roughly an average protein,
link |
00:43:01.580
which is maybe 2000 amino acids base as long,
link |
00:43:05.080
is can fold in maybe 10 to the power 300
link |
00:43:09.960
different confirmations.
link |
00:43:11.480
So there's 10 to the power 300 different ways
link |
00:43:13.320
that protein could fold up.
link |
00:43:14.800
And yet somehow in nature, physics solves this,
link |
00:43:18.160
solves this in a matter of milliseconds.
link |
00:43:20.520
So proteins fold up in your body in, you know,
link |
00:43:23.080
sometimes in fractions of a second.
link |
00:43:25.600
So physics is somehow solving that search problem.
link |
00:43:29.080
And just to be clear, in many of these cases,
link |
00:43:31.200
maybe you can correct me if I'm wrong,
link |
00:43:33.040
there's often a unique way for that sequence to form itself.
link |
00:43:37.680
So among that huge number of possibilities,
link |
00:43:41.240
it figures out a way how to stably,
link |
00:43:45.320
in some cases there might be a misfunction, so on,
link |
00:43:47.800
which leads to a lot of the disorders and stuff like that.
link |
00:43:50.040
But most of the time it's a unique mapping
link |
00:43:52.720
and that unique mapping is not obvious.
link |
00:43:54.820
No, exactly.
link |
00:43:55.660
Which is what the problem is.
link |
00:43:57.120
Exactly, so there's a unique mapping usually in a healthy,
link |
00:44:00.720
if it's healthy, and as you say in disease,
link |
00:44:04.040
so for example, Alzheimer's,
link |
00:44:05.400
one conjecture is that it's because of misfolded protein,
link |
00:44:09.000
a protein that folds in the wrong way, amyloid beta protein.
link |
00:44:12.040
So, and then because it folds in the wrong way,
link |
00:44:14.560
it gets tangled up, right, in your neurons.
link |
00:44:17.600
So it's super important to understand
link |
00:44:20.560
both healthy functioning and also disease
link |
00:44:23.600
is to understand, you know, what these things are doing
link |
00:44:26.480
and how they're structuring.
link |
00:44:27.600
Of course, the next step is sometimes proteins change shape
link |
00:44:30.540
when they interact with something.
link |
00:44:32.160
So they're not just static necessarily in biology.
link |
00:44:37.200
Maybe you can give some interesting,
link |
00:44:39.780
so beautiful things to you about these early days
link |
00:44:43.260
of AlphaFold, of solving this problem,
link |
00:44:46.160
because unlike games, this is real physical systems
link |
00:44:51.280
that are less amenable to self play type of mechanisms.
link |
00:44:55.640
Sure.
link |
00:44:56.460
The size of the data set is smaller
link |
00:44:58.440
than you might otherwise like,
link |
00:44:59.760
so you have to be very clever about certain things.
link |
00:45:01.800
Is there something you could speak to
link |
00:45:04.800
what was very hard to solve
link |
00:45:06.680
and what are some beautiful aspects about the solution?
link |
00:45:09.920
Yeah, I would say AlphaFold is the most complex
link |
00:45:12.800
and also probably most meaningful system
link |
00:45:14.600
we've built so far.
link |
00:45:15.860
So it's been an amazing time actually in the last,
link |
00:45:18.400
you know, two, three years to see that come through
link |
00:45:20.520
because as we talked about earlier, you know,
link |
00:45:23.200
games is what we started on
link |
00:45:25.480
building things like AlphaGo and AlphaZero,
link |
00:45:27.900
but really the ultimate goal was to,
link |
00:45:30.400
not just to crack games,
link |
00:45:31.520
it was just to build,
link |
00:45:33.120
use them to bootstrap general learning systems
link |
00:45:35.320
we could then apply to real world challenges.
link |
00:45:37.440
Specifically, my passion is scientific challenges
link |
00:45:40.640
like protein folding.
link |
00:45:41.920
And then AlphaFold of course
link |
00:45:43.280
is our first big proof point of that.
link |
00:45:45.360
And so, you know, in terms of the data
link |
00:45:49.040
and the amount of innovations that had to go into it,
link |
00:45:50.920
we, you know, it was like
link |
00:45:52.280
more than 30 different component algorithms
link |
00:45:54.480
needed to be put together to crack the protein folding.
link |
00:45:57.960
I think some of the big innovations were that
link |
00:46:00.800
kind of building in some hard coded constraints
link |
00:46:04.220
around physics and evolutionary biology
link |
00:46:07.760
to constrain sort of things like the bond angles
link |
00:46:11.640
in the protein and things like that,
link |
00:46:15.400
a lot, but not to impact the learning system.
link |
00:46:18.040
So still allowing the system to be able to learn
link |
00:46:21.000
the physics itself from the examples that we had.
link |
00:46:25.540
And the examples, as you say,
link |
00:46:26.640
there are only about 150,000 proteins,
link |
00:46:28.840
even after 40 years of experimental biology,
link |
00:46:31.240
only around 150,000 proteins have been,
link |
00:46:33.880
the structures have been found out about.
link |
00:46:35.920
So that was our training set,
link |
00:46:37.120
which is much less than normally we would like to use,
link |
00:46:41.120
but using various tricks, things like self distillation.
link |
00:46:43.840
So actually using AlphaFold predictions,
link |
00:46:48.280
some of the best predictions
link |
00:46:49.480
that it thought was highly confident in,
link |
00:46:51.000
we put them back into the training set, right?
link |
00:46:53.320
To make the training set bigger,
link |
00:46:55.440
that was critical to AlphaFold working.
link |
00:46:58.400
So there was actually a huge number
link |
00:47:00.160
of different innovations like that,
link |
00:47:02.720
that were required to ultimately crack the problem.
link |
00:47:06.080
AlphaFold one, what it produced was a distrogram.
link |
00:47:09.720
So a kind of a matrix of the pairwise distances
link |
00:47:13.600
between all of the molecules in the protein.
link |
00:47:17.880
And then there had to be a separate optimization process
link |
00:47:20.440
to create the 3D structure.
link |
00:47:23.640
And what we did for AlphaFold two
link |
00:47:25.120
is make it truly end to end.
link |
00:47:26.920
So we went straight from the amino acid sequence of bases
link |
00:47:31.720
to the 3D structure directly
link |
00:47:33.860
without going through this intermediate step.
link |
00:47:36.080
And in machine learning, what we've always found is
link |
00:47:38.600
that the more end to end you can make it,
link |
00:47:40.920
the better the system.
link |
00:47:42.160
And it's probably because in the end,
link |
00:47:46.160
the system's better at learning what the constraints are
link |
00:47:48.560
than we are as the human designers of specifying it.
link |
00:47:51.920
So anytime you can let it flow end to end
link |
00:47:54.040
and actually just generate what it is
link |
00:47:55.400
you're really looking for, in this case, the 3D structure,
link |
00:47:58.440
you're better off than having this intermediate step,
link |
00:48:00.560
which you then have to handcraft the next step for.
link |
00:48:03.360
So it's better to let the gradients and the learning
link |
00:48:06.160
flow all the way through the system from the end point,
link |
00:48:09.000
the end output you want to the inputs.
link |
00:48:10.880
So that's a good way to start on a new problem.
link |
00:48:13.040
Handcraft a bunch of stuff,
link |
00:48:14.360
add a bunch of manual constraints
link |
00:48:16.640
with a small end to end learning piece
link |
00:48:18.640
or a small learning piece and grow that learning piece
link |
00:48:21.560
until it consumes the whole thing.
link |
00:48:22.840
That's right.
link |
00:48:23.680
And so you can also see,
link |
00:48:25.320
this is a bit of a method we've developed
link |
00:48:26.960
over doing many sort of successful alpha,
link |
00:48:29.640
we call them alpha X projects, right?
link |
00:48:32.200
And the easiest way to see that is the evolution
link |
00:48:34.600
of alpha go to alpha zero.
link |
00:48:36.720
So alpha go was a learning system,
link |
00:48:39.640
but it was specifically trained to only play go, right?
link |
00:48:42.280
So, and what we wanted to do with first version of alpha go
link |
00:48:45.360
is just get to world champion performance
link |
00:48:47.520
no matter how we did it, right?
link |
00:48:49.200
And then of course, alpha go zero,
link |
00:48:51.400
we remove the need to use human games as a starting point,
link |
00:48:55.280
right?
link |
00:48:56.120
So it could just play against itself
link |
00:48:57.960
from random starting point from the beginning.
link |
00:49:00.280
So that removed the need for human knowledge about go.
link |
00:49:03.720
And then finally alpha zero then generalized it
link |
00:49:05.960
so that any things we had in there, the system,
link |
00:49:08.920
including things like symmetry of the go board were removed.
link |
00:49:12.240
So the alpha zero could play from scratch
link |
00:49:14.600
any two player game and then mu zero,
link |
00:49:16.440
which is the final, our latest version
link |
00:49:18.360
of that set of things was then extending it
link |
00:49:20.680
so that you didn't even have to give it
link |
00:49:22.120
the rules of the game.
link |
00:49:23.200
It would learn that for itself.
link |
00:49:24.880
So it could also deal with computer games
link |
00:49:26.600
as well as board games.
link |
00:49:27.760
So that line of alpha go, alpha go zero, alpha zero,
link |
00:49:30.400
mu zero, that's the full trajectory
link |
00:49:33.480
of what you can take from imitation learning
link |
00:49:37.200
to full self supervised learning.
link |
00:49:40.440
Yeah, exactly.
link |
00:49:41.640
And learning the entire structure
link |
00:49:44.720
of the environment you're put in from scratch, right?
link |
00:49:47.640
And bootstrapping it through self play yourself.
link |
00:49:51.840
But the thing is it would have been impossible, I think,
link |
00:49:53.720
or very hard for us to build alpha zero
link |
00:49:55.960
or mu zero first out of the box.
link |
00:49:58.600
Even psychologically, because you have to believe
link |
00:50:01.400
in yourself for a very long time.
link |
00:50:03.040
You're constantly dealing with doubt
link |
00:50:04.640
because a lot of people say that it's impossible.
link |
00:50:06.680
Exactly, so it's hard enough just to do go.
link |
00:50:08.640
As you were saying, everyone thought that was impossible
link |
00:50:10.920
or at least a decade away from when we did it
link |
00:50:14.160
back in 2015, 2016.
link |
00:50:17.320
And so yes, it would have been psychologically
link |
00:50:20.960
probably very difficult as well as the fact
link |
00:50:22.960
that of course we learn a lot by building alpha go first.
link |
00:50:26.400
Right, so I think this is why I call AI
link |
00:50:28.520
an engineering science.
link |
00:50:29.880
It's one of the most fascinating science disciplines,
link |
00:50:32.280
but it's also an engineering science in the sense
link |
00:50:34.200
that unlike natural sciences, the phenomenon you're studying
link |
00:50:38.200
doesn't exist out in nature.
link |
00:50:39.440
You have to build it first.
link |
00:50:40.880
So you have to build the artifact first,
link |
00:50:42.480
and then you can study and pull it apart and how it works.
link |
00:50:46.480
This is tough to ask you this question
link |
00:50:50.000
because you probably will say it's everything,
link |
00:50:51.480
but let's try to think through this
link |
00:50:54.360
because you're in a very interesting position
link |
00:50:56.480
where DeepMind is a place of some of the most brilliant
link |
00:50:59.520
ideas in the history of AI,
link |
00:51:01.760
but it's also a place of brilliant engineering.
link |
00:51:05.880
So how much of solving intelligence,
link |
00:51:08.040
this big goal for DeepMind,
link |
00:51:09.880
how much of it is science?
link |
00:51:12.120
How much is engineering?
link |
00:51:13.320
So how much is the algorithms?
link |
00:51:14.720
How much is the data?
link |
00:51:16.160
How much is the hardware compute infrastructure?
link |
00:51:19.840
How much is it the software compute infrastructure?
link |
00:51:23.960
What else is there?
link |
00:51:24.800
How much is the human infrastructure?
link |
00:51:27.200
And like just the humans interacting certain kinds of ways
link |
00:51:30.280
in all the space of all those ideas.
link |
00:51:31.720
And how much is maybe like philosophy?
link |
00:51:33.640
How much, what's the key?
link |
00:51:35.160
If you were to sort of look back,
link |
00:51:40.680
like if we go forward 200 years and look back,
link |
00:51:43.200
what was the key thing that solved intelligence?
link |
00:51:46.320
Is it the ideas or the engineering?
link |
00:51:47.800
I think it's a combination.
link |
00:51:49.040
First of all, of course,
link |
00:51:49.880
it's a combination of all those things,
link |
00:51:51.360
but the ratios of them changed over time.
link |
00:51:54.760
So even in the last 12 years,
link |
00:51:57.480
so we started DeepMind in 2010,
link |
00:51:59.400
which is hard to imagine now because 2010,
link |
00:52:01.920
it's only 12 short years ago,
link |
00:52:03.400
but nobody was talking about AI.
link |
00:52:05.600
I don't know if you remember back to your MIT days,
link |
00:52:07.600
no one was talking about it.
link |
00:52:08.720
I did a postdoc at MIT back around then.
link |
00:52:11.080
And it was sort of thought of as a,
link |
00:52:12.880
well, look, we know AI doesn't work.
link |
00:52:14.200
We tried this hard in the 90s at places like MIT,
link |
00:52:17.040
mostly using logic systems and old fashioned,
link |
00:52:19.880
sort of good old fashioned AI, we would call it now.
link |
00:52:22.600
People like Minsky and Patrick Winston,
link |
00:52:25.320
and you know all these characters, right?
link |
00:52:26.720
And used to debate a few of them.
link |
00:52:28.280
And they used to think I was mad thinking about
link |
00:52:30.120
that some new advance could be done with learning systems.
link |
00:52:32.360
And I was actually pleased to hear that
link |
00:52:34.720
because at least you know you're on a unique track
link |
00:52:36.960
at that point, right?
link |
00:52:37.840
Even if all of your professors are telling you you're mad.
link |
00:52:41.880
And of course in industry,
link |
00:52:43.840
we couldn't get, it was difficult to get two cents together,
link |
00:52:47.680
which is hard to imagine now as well,
link |
00:52:48.920
given that it's the biggest sort of buzzword in VCs
link |
00:52:51.560
and fundraisings easy and all these kinds of things today.
link |
00:52:54.720
So back in 2010, it was very difficult.
link |
00:52:57.720
And the reason we started then,
link |
00:52:59.360
and Shane and I used to discuss
link |
00:53:02.480
what were the sort of founding tenants of DeepMind.
link |
00:53:04.920
And it was various things.
link |
00:53:06.120
One was algorithmic advances.
link |
00:53:08.680
So deep learning, you know,
link |
00:53:09.760
Jeff Hinton and Co had just sort of invented that
link |
00:53:12.360
in academia, but no one in industry knew about it.
link |
00:53:15.200
We love reinforcement learning.
link |
00:53:16.640
We thought that could be scaled up.
link |
00:53:18.240
But also understanding about the human brain
link |
00:53:20.160
had advanced quite a lot in the decade prior
link |
00:53:23.920
with fMRI machines and other things.
link |
00:53:25.440
So we could get some good hints about architectures
link |
00:53:28.840
and algorithms and sort of representations maybe
link |
00:53:32.480
that the brain uses.
link |
00:53:33.400
So at a systems level, not at a implementation level.
link |
00:53:37.760
And then the other big things were compute and GPUs, right?
link |
00:53:41.040
So we could see a compute was going to be really useful
link |
00:53:44.160
and had got to a place where it become commoditized
link |
00:53:46.960
mostly through the games industry
link |
00:53:48.560
and that could be taken advantage of.
link |
00:53:50.760
And then the final thing was also mathematical
link |
00:53:52.800
and theoretical definitions of intelligence.
link |
00:53:54.960
So things like AIXI, AIXE,
link |
00:53:57.560
which Shane worked on with his supervisor, Marcus Hutter,
link |
00:54:00.160
which is this sort of theoretical proof really
link |
00:54:03.360
of universal intelligence,
link |
00:54:05.280
which is actually a reinforcement learning system
link |
00:54:08.000
in the limit.
link |
00:54:08.840
I mean, it assumes infinite compute and infinite memory
link |
00:54:10.640
in the way, you know, like a Turing machine proves.
link |
00:54:12.920
But I was also waiting to see something like that too,
link |
00:54:15.840
to, you know, like Turing machines and computation theory
link |
00:54:19.440
that people like Turing and Shannon came up with
link |
00:54:21.520
underpins modern computer science.
link |
00:54:24.800
You know, I was waiting for a theory like that
link |
00:54:26.400
to sort of underpin AGI research.
link |
00:54:28.880
So when I, you know, met Shane
link |
00:54:30.120
and saw he was working on something like that,
link |
00:54:32.000
you know, that to me was a sort of final piece
link |
00:54:33.680
of the jigsaw.
link |
00:54:34.560
So in the early days, I would say that ideas
link |
00:54:38.320
were the most important.
link |
00:54:40.040
You know, for us, it was deep reinforcement learning,
link |
00:54:42.440
scaling up deep learning.
link |
00:54:44.600
Of course, we've seen transformers.
link |
00:54:46.240
So huge leaps, I would say, you know, three or four
link |
00:54:48.920
from, if you think from 2010 till now,
link |
00:54:51.520
huge evolutions, things like AlphaGo.
link |
00:54:53.680
And maybe there's a few more still needed.
link |
00:54:57.920
But as we get closer to AI, AGI,
link |
00:55:02.000
I think engineering becomes more and more important
link |
00:55:04.600
and data because scale and of course the recent,
link |
00:55:07.800
you know, results of GPT3 and all the big language models
link |
00:55:10.440
and large models, including our ones,
link |
00:55:12.800
has shown that scale and large models
link |
00:55:16.000
are clearly gonna be a necessary,
link |
00:55:18.080
but perhaps not sufficient part of an AGI solution.
link |
00:55:21.960
And throughout that, like you said,
link |
00:55:24.560
and I'd like to give you a big thank you.
link |
00:55:26.720
You're one of the pioneers in this is sticking by ideas
link |
00:55:30.640
like reinforcement learning, that this can actually work
link |
00:55:34.560
given actually limited success in the past.
link |
00:55:38.480
And also, which we still don't know,
link |
00:55:41.480
but proudly having the best researchers in the world
link |
00:55:46.760
and talking about solving intelligence.
link |
00:55:49.400
So talking about whatever you call it,
link |
00:55:50.920
AGI or something like this, speaking of MIT,
link |
00:55:54.720
that's just something you wouldn't bring up.
link |
00:55:57.240
Not maybe you did in like 40, 50 years ago,
link |
00:56:03.560
but that was, AI was a place where you do tinkering,
link |
00:56:09.320
very small scale, not very ambitious projects.
link |
00:56:12.560
And maybe the biggest ambitious projects
link |
00:56:16.160
were in the space of robotics
link |
00:56:17.480
and doing like the DARPA challenge.
link |
00:56:19.200
But the task of solving intelligence and believing you can,
link |
00:56:23.400
that's really, really powerful.
link |
00:56:24.560
So in order for engineering to do its work,
link |
00:56:27.680
to have great engineers, build great systems,
link |
00:56:30.960
you have to have that belief,
link |
00:56:32.360
that threads throughout the whole thing
link |
00:56:33.920
that you can actually solve
link |
00:56:35.040
some of these impossible challenges.
link |
00:56:36.640
Yeah, that's right.
link |
00:56:37.480
And back in 2010, our mission statement and still is today,
link |
00:56:42.280
it was used to be solving step one, solve intelligence,
link |
00:56:45.600
step two, use it to solve everything else.
link |
00:56:47.520
So if you can imagine pitching that to a VC in 2010,
link |
00:56:51.120
the kind of looks we got,
link |
00:56:52.680
we managed to find a few kooky people to back us,
link |
00:56:55.880
but it was tricky.
link |
00:56:57.680
And it got to the point where we wouldn't mention it
link |
00:57:00.160
to any of our professors because they would just eye roll
link |
00:57:03.120
and think we committed career suicide.
link |
00:57:05.760
And so it was, there's a lot of things that we had to do,
link |
00:57:10.040
but we always believed it.
link |
00:57:11.560
And one reason, by the way,
link |
00:57:13.240
one reason I've always believed in reinforcement learning
link |
00:57:16.160
is that if you look at neuroscience,
link |
00:57:19.120
that is the way that the primate brain learns.
link |
00:57:22.720
One of the main mechanisms is the dopamine system
link |
00:57:24.880
implements some form of TD learning.
link |
00:57:26.440
It was a very famous result in the late 90s
link |
00:57:29.680
where they saw this in monkeys
link |
00:57:31.320
and as a propagating prediction error.
link |
00:57:34.520
So again, in the limit,
link |
00:57:36.800
this is what I think you can use neuroscience for is,
link |
00:57:39.480
at mathematics, when you're doing something as ambitious
link |
00:57:43.160
as trying to solve intelligence
link |
00:57:44.560
and it's blue sky research, no one knows how to do it,
link |
00:57:47.760
you need to use any evidence
link |
00:57:50.160
or any source of information you can
link |
00:57:52.120
to help guide you in the right direction
link |
00:57:54.280
or give you confidence you're going in the right direction.
link |
00:57:56.680
So that was one reason we pushed so hard on that.
link |
00:57:59.840
And just going back to your earlier question
link |
00:58:01.840
about organization, the other big thing
link |
00:58:04.280
that I think we innovated with at DeepMind
link |
00:58:06.000
to encourage invention and innovation
link |
00:58:10.320
was the multidisciplinary organization we built
link |
00:58:12.920
and we still have today.
link |
00:58:14.160
So DeepMind originally was a confluence
link |
00:58:16.680
of the most cutting edge knowledge in neuroscience
link |
00:58:19.400
with machine learning, engineering and mathematics, right?
link |
00:58:22.840
And gaming.
link |
00:58:24.400
And then since then we've built that out even further.
link |
00:58:26.760
So we have philosophers here and ethicists,
link |
00:58:30.280
but also other types of scientists, physicists and so on.
link |
00:58:33.160
And that's what brings together,
link |
00:58:35.160
I tried to build a sort of new type of Bell Labs,
link |
00:58:38.760
but in its golden era, right?
link |
00:58:41.200
And a new expression of that to try and foster
link |
00:58:45.680
this incredible sort of innovation machine.
link |
00:58:48.480
So talking about the humans in the machine,
link |
00:58:50.600
DeepMind itself is a learning machine
link |
00:58:53.080
with lots of amazing human minds in it
link |
00:58:55.600
coming together to try and build these learning systems.
link |
00:59:00.360
If we return to the big ambitious dream of AlphaFold,
link |
00:59:04.960
that may be the early steps on a very long journey
link |
00:59:08.400
in biology, do you think the same kind of approach
link |
00:59:14.200
can use to predict the structure and function
link |
00:59:16.400
of more complex biological systems?
link |
00:59:18.720
So multi protein interaction,
link |
00:59:21.480
and then, I mean, you can go out from there,
link |
00:59:24.400
just simulating bigger and bigger systems
link |
00:59:26.920
that eventually simulate something like the human brain
link |
00:59:29.560
or the human body, just the big mush,
link |
00:59:32.560
the mess of the beautiful, resilient mess of biology.
link |
00:59:36.480
Do you see that as a long term vision?
link |
00:59:39.600
I do, and I think, if you think about
link |
00:59:42.560
what are the top things I wanted to apply AI to
link |
00:59:45.680
once we had powerful enough systems,
link |
00:59:47.680
biology and curing diseases and understanding biology
link |
00:59:52.240
was right up there, top of my list.
link |
00:59:54.120
That's one of the reasons I personally pushed that myself
link |
00:59:56.760
and with AlphaFold, but I think AlphaFold,
link |
01:00:00.200
amazing as it is, is just the beginning.
link |
01:00:03.000
And I hope it's evidence of what could be done
link |
01:00:07.160
with computational methods.
link |
01:00:08.800
So AlphaFold solved this huge problem
link |
01:00:12.200
of the structure of proteins, but biology is dynamic.
link |
01:00:15.240
So really what I imagine from here,
link |
01:00:16.880
and we're working on all these things now,
link |
01:00:18.640
is protein, protein interaction, protein ligand binding,
link |
01:00:23.160
so reacting with molecules,
link |
01:00:25.400
then you wanna build up to pathways,
link |
01:00:27.640
and then eventually a virtual cell.
link |
01:00:30.000
That's my dream, maybe in the next 10 years.
link |
01:00:32.680
And I've been talking actually
link |
01:00:33.600
to a lot of biologists, friends of mine,
link |
01:00:35.000
Paul Nurse, who runs the Crick Institute,
link |
01:00:36.760
amazing biologists, Nobel Prize winning biologists.
link |
01:00:39.080
We've been discussing for 20 years now, virtual cells.
link |
01:00:42.080
Could you build a virtual simulation of a cell?
link |
01:00:44.720
And if you could, that would be incredible
link |
01:00:46.240
for biology and disease discovery,
link |
01:00:48.120
because you could do loads of experiments
link |
01:00:49.520
on the virtual cell, and then only at the last stage,
link |
01:00:52.400
validate it in the wet lab.
link |
01:00:53.920
So you could, in terms of the search space
link |
01:00:56.400
of discovering new drugs, it takes 10 years roughly
link |
01:00:59.200
to go from identifying a target,
link |
01:01:03.360
to having a drug candidate.
link |
01:01:06.480
Maybe that could be shortened by an order of magnitude,
link |
01:01:09.760
if you could do most of that work in silico.
link |
01:01:13.120
So in order to get to a virtual cell,
link |
01:01:15.720
we have to build up understanding
link |
01:01:18.320
of different parts of biology and the interactions.
link |
01:01:20.760
And so every few years we talk about this,
link |
01:01:24.560
I talked about this with Paul.
link |
01:01:25.600
And then finally, last year after AlphaFold,
link |
01:01:27.840
I said, now's the time we can finally go for it.
link |
01:01:30.600
And AlphaFold is the first proof point
link |
01:01:32.360
that this might be possible.
link |
01:01:33.800
And he's very excited, and we have some collaborations
link |
01:01:35.920
with his lab, they're just across the road actually
link |
01:01:38.480
from us, it's wonderful being here in King's Cross
link |
01:01:40.960
with the Crick Institute across the road.
link |
01:01:42.880
And I think the next steps,
link |
01:01:45.960
I think there's gonna be some amazing advances
link |
01:01:48.040
in biology built on top of things like AlphaFold.
link |
01:01:50.960
We're already seeing that with the community doing that
link |
01:01:53.160
after we've open sourced it and released it.
link |
01:01:56.000
And I often say that I think if you think of mathematics
link |
01:02:02.360
is the perfect description language for physics,
link |
01:02:05.080
I think AI might be end up being
link |
01:02:06.920
the perfect description language for biology
link |
01:02:09.280
because biology is so messy, it's so emergent,
link |
01:02:13.040
so dynamic and complex.
link |
01:02:15.320
I think I find it very hard to believe
link |
01:02:16.920
we'll ever get to something as elegant
link |
01:02:18.600
as Newton's laws of motions to describe a cell, right?
link |
01:02:21.760
It's just too complicated.
link |
01:02:23.600
So I think AI is the right tool for that.
link |
01:02:26.160
So you have to start at the basic building blocks
link |
01:02:29.480
and use AI to run the simulation
link |
01:02:31.680
for all those building blocks.
link |
01:02:32.880
So have a very strong way to do prediction
link |
01:02:36.040
of what given these building blocks,
link |
01:02:37.800
what kind of biology, how the function
link |
01:02:40.880
and the evolution of that biological system.
link |
01:02:43.640
It's almost like a cellular automata,
link |
01:02:45.280
you have to run it, you can't analyze it from a high level.
link |
01:02:47.880
You have to take the basic ingredients,
link |
01:02:49.840
figure out the rules and let it run.
link |
01:02:51.960
But in this case, the rules are very difficult
link |
01:02:53.960
to figure out, you have to learn them.
link |
01:02:56.200
That's exactly it.
link |
01:02:57.040
So the biology is too complicated to figure out the rules.
link |
01:03:00.800
It's too emergent, too dynamic,
link |
01:03:03.600
say compared to a physics system,
link |
01:03:05.080
like the motion of a planet, right?
link |
01:03:07.040
And so you have to learn the rules
link |
01:03:09.200
and that's exactly the type of systems that we're building.
link |
01:03:11.920
So you mentioned you've open sourced AlphaFold
link |
01:03:14.800
and even the data involved.
link |
01:03:16.640
To me personally, also really happy
link |
01:03:20.040
and a big thank you for open sourcing Mojoko,
link |
01:03:23.520
the physics simulation engine that's often used
link |
01:03:27.080
for robotics research and so on.
link |
01:03:29.080
So I think that's a pretty gangster move.
link |
01:03:31.120
So what's the, I mean, very few companies
link |
01:03:37.200
or people do that kind of thing.
link |
01:03:39.080
What's the philosophy behind that?
link |
01:03:41.240
You know, it's a case by case basis.
link |
01:03:42.920
And in both of those cases,
link |
01:03:44.040
we felt that was the maximum benefit to humanity to do that.
link |
01:03:47.360
And the scientific community, in one case,
link |
01:03:50.040
the robotics physics community with Mojoko, so.
link |
01:03:53.360
We purchased it.
link |
01:03:54.200
We purchased it for, yes,
link |
01:03:55.840
we purchased it for the express principle to open source it.
link |
01:03:58.520
So, you know, I hope people appreciate that.
link |
01:04:02.440
It's great to hear that you do.
link |
01:04:04.040
And then the second thing was,
link |
01:04:05.800
and mostly we did it because the person building it
link |
01:04:08.040
was not able to cope with supporting it anymore
link |
01:04:11.920
because it got too big for him.
link |
01:04:13.600
He's an amazing professor who built it in the first place.
link |
01:04:16.720
So we helped him out with that.
link |
01:04:18.240
And then with AlphaFold is even bigger, I would say.
link |
01:04:20.520
And I think in that case,
link |
01:04:21.960
we decided that there were so many downstream applications
link |
01:04:25.520
of AlphaFold that we couldn't possibly even imagine
link |
01:04:29.400
what they all were.
link |
01:04:30.480
So the best way to accelerate drug discovery
link |
01:04:34.360
and also fundamental research would be to give all
link |
01:04:38.680
that data away and the system itself.
link |
01:04:43.240
You know, it's been so gratifying to see
link |
01:04:45.280
what people have done that within just one year,
link |
01:04:47.040
which is a short amount of time in science.
link |
01:04:49.240
And it's been used by over 500,000 researchers have used it.
link |
01:04:54.160
We think that's almost every biologist in the world.
link |
01:04:56.560
I think there's roughly 500,000 biologists in the world,
link |
01:04:58.840
professional biologists,
link |
01:05:00.000
have used it to look at their proteins of interest.
link |
01:05:04.480
We've seen amazing fundamental research done.
link |
01:05:06.520
So a couple of weeks ago, front cover,
link |
01:05:09.040
there was a whole special issue of science,
link |
01:05:10.840
including the front cover,
link |
01:05:12.040
which had the nuclear pore complex on it,
link |
01:05:14.000
which is one of the biggest proteins in the body.
link |
01:05:15.800
The nuclear pore complex is a protein that governs
link |
01:05:18.960
all the nutrients going in and out of your cell nucleus.
link |
01:05:21.680
So they're like little gateways that open and close
link |
01:05:24.760
to let things go in and out of your cell nucleus.
link |
01:05:27.320
So they're really important, but they're huge
link |
01:05:29.400
because they're massive donut ring shaped things.
link |
01:05:31.680
And they've been looking to try and figure out
link |
01:05:33.440
that structure for decades.
link |
01:05:34.960
And they have lots of experimental data,
link |
01:05:37.160
but it's too low resolution, there's bits missing.
link |
01:05:39.600
And they were able to, like a giant Lego jigsaw puzzle,
link |
01:05:43.080
use alpha fold predictions plus experimental data
link |
01:05:46.200
and combined those two independent sources of information,
link |
01:05:49.760
actually four different groups around the world
link |
01:05:51.240
were able to put it together more or less simultaneously
link |
01:05:54.600
using alpha fold predictions.
link |
01:05:56.280
So that's been amazing to see.
link |
01:05:57.720
And pretty much every pharma company,
link |
01:05:59.400
every drug company executive I've spoken to
link |
01:06:01.440
has said that their teams are using alpha fold
link |
01:06:03.760
to accelerate whatever drugs they're trying to discover.
link |
01:06:08.040
So I think the knock on effect has been enormous
link |
01:06:11.440
in terms of the impact that alpha fold has made.
link |
01:06:15.240
And it's probably bringing in, it's creating biologists,
link |
01:06:17.840
it's bringing more people into the field,
link |
01:06:20.800
both on the excitement and both on the technical skills
link |
01:06:23.320
involved in, it's almost like a gateway drug to biology.
link |
01:06:28.760
Yes, it is.
link |
01:06:29.600
And to get more computational people involved too, hopefully.
link |
01:06:32.640
And I think for us, the next stage, as I said,
link |
01:06:35.920
in future we have to have other considerations too.
link |
01:06:37.960
We're building on top of alpha fold
link |
01:06:39.640
and these other ideas I discussed with you
link |
01:06:41.200
about protein interactions and genomics and other things.
link |
01:06:44.800
And not everything will be open source.
link |
01:06:46.200
Some of it we'll do commercially
link |
01:06:48.000
because that will be the best way
link |
01:06:49.000
to actually get the most resources and impact behind it.
link |
01:06:51.720
In other ways, some other projects
link |
01:06:53.480
we'll do nonprofit style.
link |
01:06:55.280
And also we have to consider for future things as well,
link |
01:06:58.520
safety and ethics as well.
link |
01:06:59.720
Like synthetic biology, there is dual use.
link |
01:07:03.600
And we have to think about that as well.
link |
01:07:05.080
With alpha fold, we consulted with 30 different bioethicists
link |
01:07:08.600
and other people expert in this field
link |
01:07:10.240
to make sure it was safe before we released it.
link |
01:07:13.280
So there'll be other considerations in future.
link |
01:07:15.280
But for right now, I think alpha fold
link |
01:07:17.120
is a kind of a gift from us to the scientific community.
link |
01:07:20.840
So I'm pretty sure that something like alpha fold
link |
01:07:25.600
will be part of Nobel prizes in the future.
link |
01:07:29.080
But us humans, of course,
link |
01:07:30.840
are horrible with credit assignment.
link |
01:07:32.480
So we'll of course give it to the humans.
link |
01:07:35.560
Do you think there will be a day
link |
01:07:37.440
when AI system can't be denied
link |
01:07:42.520
that it earned that Nobel prize?
link |
01:07:45.120
Do you think we will see that in 21st century?
link |
01:07:47.400
It depends what type of AIs we end up building, right?
link |
01:07:50.200
Whether they're goal seeking agents
link |
01:07:53.600
who specifies the goals, who comes up with the hypotheses,
link |
01:07:57.800
who determines which problems to tackle, right?
link |
01:08:00.320
So I think...
link |
01:08:01.160
And tweets about it, announcement of the results.
link |
01:08:02.440
Yes, and tweets about results exactly as part of it.
link |
01:08:05.440
So I think right now, of course,
link |
01:08:07.760
it's amazing human ingenuity that's behind these systems.
link |
01:08:12.200
And then the system, in my opinion, is just a tool.
link |
01:08:15.120
Be a bit like saying with Galileo and his telescope,
link |
01:08:18.400
the ingenuity that the credit should go to the telescope.
link |
01:08:21.160
I mean, it's clearly Galileo building the tool
link |
01:08:23.560
which he then uses.
link |
01:08:25.160
So I still see that in the same way today,
link |
01:08:27.320
even though these tools learn for themselves.
link |
01:08:30.440
There, I think of things like alpha fold
link |
01:08:32.960
and the things we're building as the ultimate tools
link |
01:08:35.840
for science and for acquiring new knowledge
link |
01:08:38.560
to help us as scientists acquire new knowledge.
link |
01:08:41.160
I think one day there will come a point
link |
01:08:43.200
where an AI system may solve
link |
01:08:46.360
or come up with something like general relativity
link |
01:08:48.800
of its own bat, not just by averaging everything
link |
01:08:52.040
on the internet or averaging everything on PubMed,
link |
01:08:55.240
although that would be interesting to see
link |
01:08:56.320
what that would come up with.
link |
01:08:58.520
So that to me is a bit like our earlier debate
link |
01:09:00.400
about creativity, you know, inventing go
link |
01:09:03.240
rather than just coming up with a good go move.
link |
01:09:06.280
And so I think solving, I think to, you know,
link |
01:09:10.400
if we wanted to give it the credit
link |
01:09:11.800
of like a Nobel type of thing,
link |
01:09:13.520
then it would need to invent go
link |
01:09:15.800
and sort of invent that new conjecture out of the blue
link |
01:09:19.280
rather than being specified by the human scientists
link |
01:09:22.720
or the human creators.
link |
01:09:23.560
So I think right now it's definitely just a tool.
link |
01:09:26.280
Although it is interesting how far you get
link |
01:09:27.880
by averaging everything on the internet, like you said,
link |
01:09:29.960
because, you know, a lot of people do see science
link |
01:09:33.160
as you're always standing on the shoulders of giants.
link |
01:09:35.640
And the question is how much are you really reaching
link |
01:09:40.040
up above the shoulders of giants?
link |
01:09:42.000
Maybe it's just simulating different kinds
link |
01:09:44.700
of results of the past with ultimately this new perspective
link |
01:09:49.360
that gives you this breakthrough idea.
link |
01:09:51.120
But that idea may not be novel in the way
link |
01:09:54.860
that it can't be already discovered on the internet.
link |
01:09:56.740
Maybe the Nobel prizes of the next 100 years
link |
01:10:00.080
are already all there on the internet to be discovered.
link |
01:10:03.040
They could be, they could be.
link |
01:10:04.560
I mean, I think this is one of the big mysteries,
link |
01:10:08.560
I think is that I, first of all,
link |
01:10:11.720
I believe a lot of the big new breakthroughs
link |
01:10:13.760
that are gonna come in the next few decades
link |
01:10:15.280
and even in the last decade are gonna come
link |
01:10:17.400
at the intersection between different subject areas
link |
01:10:20.200
where there'll be some new connection that's found
link |
01:10:23.480
between what seemingly were disparate areas.
link |
01:10:26.180
And one can even think of DeepMind, as I said earlier,
link |
01:10:28.840
as a sort of interdisciplinary between neuroscience ideas
link |
01:10:31.720
and AI engineering ideas originally.
link |
01:10:35.040
And so I think there's that.
link |
01:10:37.960
And then one of the things we can't imagine today is,
link |
01:10:40.380
and one of the reasons I think people,
link |
01:10:41.720
we were so surprised by how well large models worked
link |
01:10:44.440
is that actually it's very hard for our human minds,
link |
01:10:47.900
our limited human minds to understand
link |
01:10:49.440
what it would be like to read the whole internet, right?
link |
01:10:52.020
I think we can do a thought experiment
link |
01:10:53.520
and I used to do this of like,
link |
01:10:54.680
well, what if I read the whole of Wikipedia?
link |
01:10:57.600
What would I know?
link |
01:10:58.440
And I think our minds can just about comprehend
link |
01:11:00.480
maybe what that would be like,
link |
01:11:01.920
but the whole internet is beyond comprehension.
link |
01:11:04.440
So I think we just don't understand what it would be like
link |
01:11:07.420
to be able to hold all of that in mind potentially, right?
link |
01:11:10.320
And then active at once,
link |
01:11:12.920
and then maybe what are the connections
link |
01:11:14.520
that are available there?
link |
01:11:15.780
So I think no doubt there are huge things
link |
01:11:17.520
to be discovered just like that.
link |
01:11:19.280
But I do think there is this other type of creativity
link |
01:11:22.280
of true spark of new knowledge, new idea,
link |
01:11:25.400
never thought before about,
link |
01:11:26.680
can't be averaged from things that are known,
link |
01:11:29.320
that really, of course, everything come,
link |
01:11:32.000
nobody creates in a vacuum,
link |
01:11:33.680
so there must be clues somewhere,
link |
01:11:35.420
but just a unique way of putting those things together.
link |
01:11:38.280
I think some of the greatest scientists in history
link |
01:11:40.480
have displayed that I would say,
link |
01:11:42.240
although it's very hard to know going back to their time,
link |
01:11:45.120
what was exactly known when they came up with those things.
link |
01:11:48.120
Although you're making me really think because just a thought
link |
01:11:52.440
experiment of deeply knowing a hundred Wikipedia pages.
link |
01:11:57.360
I don't think I can,
link |
01:11:59.200
I've been really impressed by Wikipedia for technical topics.
link |
01:12:03.400
So if you know a hundred pages or a thousand pages,
link |
01:12:07.040
I don't think we can truly comprehend
link |
01:12:10.120
what kind of intelligence that is.
link |
01:12:13.400
That's a pretty powerful intelligence.
link |
01:12:14.760
If you know how to use that
link |
01:12:16.120
and integrate that information correctly,
link |
01:12:18.320
I think you can go really far.
link |
01:12:20.000
You can probably construct thought experiments
link |
01:12:22.080
based on that, like simulate different ideas.
link |
01:12:25.840
So if this is true, let me run this thought experiment
link |
01:12:28.840
that maybe this is true.
link |
01:12:30.160
It's not really invention.
link |
01:12:31.360
It's like just taking literally the knowledge
link |
01:12:34.640
and using it to construct the very basic simulation
link |
01:12:37.240
of the world.
link |
01:12:38.080
I mean, some argue it's romantic in part,
link |
01:12:40.080
but Einstein would do the same kind of things
link |
01:12:42.400
with a thought experiment.
link |
01:12:43.720
Yeah, one could imagine doing that systematically
link |
01:12:46.320
across millions of Wikipedia pages,
link |
01:12:48.440
plus PubMed, all these things.
link |
01:12:50.400
I think there are many, many things to be discovered
link |
01:12:53.680
like that that are hugely useful.
link |
01:12:55.280
You could imagine,
link |
01:12:56.200
and I want us to do some of these things in material science
link |
01:12:58.520
like room temperature superconductors
link |
01:13:00.000
is something on my list one day.
link |
01:13:01.560
I'd like to have an AI system to help build
link |
01:13:05.000
better optimized batteries,
link |
01:13:06.640
all of these sort of mechanical things.
link |
01:13:09.000
I think a systematic sort of search
link |
01:13:11.600
could be guided by a model,
link |
01:13:14.360
could be extremely powerful.
link |
01:13:17.120
So speaking of which,
link |
01:13:18.160
you have a paper on nuclear fusion,
link |
01:13:21.320
magnetic control of tachymic plasmas
link |
01:13:23.120
through deep reinforcement learning.
link |
01:13:24.720
So you're seeking to solve nuclear fusion with deep RL.
link |
01:13:29.800
So it's doing control of high temperature plasmas.
link |
01:13:31.840
Can you explain this work
link |
01:13:33.520
and can AI eventually solve nuclear fusion?
link |
01:13:37.240
It's been very fun last year or two and very productive
link |
01:13:40.200
because we've been taking off a lot of my dream projects,
link |
01:13:43.360
if you like, of things that I've collected
link |
01:13:44.960
over the years of areas of science
link |
01:13:46.960
that I would like to,
link |
01:13:48.200
I think could be very transformative if we helped accelerate
link |
01:13:51.200
and really interesting problems,
link |
01:13:53.600
scientific challenges in of themselves.
link |
01:13:55.760
So this is energy.
link |
01:13:57.040
So energy, yes, exactly.
link |
01:13:58.520
So energy and climate.
link |
01:13:59.960
So we talked about disease and biology
link |
01:14:01.760
as being one of the biggest places I think AI can help with.
link |
01:14:04.520
I think energy and climate is another one.
link |
01:14:07.120
So maybe they would be my top two.
link |
01:14:09.240
And fusion is one area I think AI can help with.
link |
01:14:12.520
Now, fusion has many challenges,
link |
01:14:15.360
mostly physics and material science
link |
01:14:17.240
and engineering challenges as well
link |
01:14:18.600
to build these massive fusion reactors
link |
01:14:20.520
and contain the plasma.
link |
01:14:21.920
And what we try to do,
link |
01:14:22.760
and whenever we go into a new field to apply our systems,
link |
01:14:26.280
is we look for, we talk to domain experts.
link |
01:14:29.240
We try and find the best people in the world
link |
01:14:30.680
to collaborate with.
link |
01:14:33.000
In this case, in fusion,
link |
01:14:34.120
we collaborated with EPFL in Switzerland,
link |
01:14:36.400
the Swiss Technical Institute, who are amazing.
link |
01:14:38.280
They have a test reactor.
link |
01:14:39.640
They were willing to let us use,
link |
01:14:41.360
which I double checked with the team
link |
01:14:43.400
we were gonna use carefully and safely.
link |
01:14:46.120
I was impressed they managed to persuade them
link |
01:14:47.760
to let us use it.
link |
01:14:49.160
And it's an amazing test reactor they have there.
link |
01:14:53.440
And they try all sorts of pretty crazy experiments on it.
link |
01:14:57.000
And what we tend to look at is,
link |
01:14:59.720
if we go into a new domain like fusion,
link |
01:15:01.760
what are all the bottleneck problems?
link |
01:15:04.160
Like thinking from first principles,
link |
01:15:05.960
what are all the bottleneck problems
link |
01:15:07.000
that are still stopping fusion working today?
link |
01:15:09.280
And then we look at, we get a fusion expert to tell us,
link |
01:15:12.080
and then we look at those bottlenecks
link |
01:15:13.760
and we look at the ones,
link |
01:15:14.600
which ones are amenable to our AI methods today, right?
link |
01:15:18.920
And would be interesting from a research perspective,
link |
01:15:22.200
from our point of view, from an AI point of view,
link |
01:15:24.400
and that would address one of their bottlenecks.
link |
01:15:26.760
And in this case, plasma control was perfect.
link |
01:15:29.720
So, the plasma, it's a million degrees Celsius,
link |
01:15:32.480
something like that, it's hotter than the sun.
link |
01:15:34.640
And there's obviously no material that can contain it.
link |
01:15:37.640
So, they have to be containing these magnetic,
link |
01:15:39.440
very powerful and superconducting magnetic fields.
link |
01:15:42.520
But the problem is plasma,
link |
01:15:43.960
it's pretty unstable as you imagine,
link |
01:15:45.360
you're kind of holding a mini sun, mini star in a reactor.
link |
01:15:49.320
So, you kind of want to predict ahead of time,
link |
01:15:52.520
what the plasma is gonna do.
link |
01:15:54.040
So, you can move the magnetic field
link |
01:15:56.240
within a few milliseconds,
link |
01:15:58.440
to basically contain what it's gonna do next.
link |
01:16:00.960
So, it seems like a perfect problem if you think of it
link |
01:16:03.160
for like a reinforcement learning prediction problem.
link |
01:16:06.280
So, you got controller, you're gonna move the magnetic field.
link |
01:16:09.720
And until we came along, they were doing it
link |
01:16:12.560
with traditional operational research type of controllers,
link |
01:16:16.720
which are kind of handcrafted.
link |
01:16:18.320
And the problem is, of course,
link |
01:16:19.160
they can't react in the moment
link |
01:16:20.480
to something the plasma is doing,
link |
01:16:21.640
they have to be hard coded.
link |
01:16:23.040
And again, knowing that that's normally our go to solution
link |
01:16:26.040
is we would like to learn that instead.
link |
01:16:27.960
And they also had a simulator of these plasma.
link |
01:16:30.320
So, there were lots of criteria
link |
01:16:31.480
that matched what we like to use.
link |
01:16:34.760
So, can AI eventually solve nuclear fusion?
link |
01:16:38.440
Well, so with this problem,
link |
01:16:39.760
and we published it in a nature paper last year,
link |
01:16:42.040
we held the fusion, we held the plasma in a specific shapes.
link |
01:16:46.160
So, actually, it's almost like carving the plasma
link |
01:16:48.360
into different shapes and hold it there
link |
01:16:51.000
for a record amount of time.
link |
01:16:52.880
So, that's one of the problems of fusion sort of solved.
link |
01:16:57.600
So, have a controller that's able to,
link |
01:16:59.840
no matter the shape.
link |
01:17:01.480
Contain it. Contain it.
link |
01:17:02.360
Yeah, contain it and hold it in structure.
link |
01:17:04.160
And there's different shapes that are better
link |
01:17:05.760
for the energy productions called droplets and so on.
link |
01:17:10.080
So, that was huge.
link |
01:17:11.880
And now we're looking,
link |
01:17:12.720
we're talking to lots of fusion startups
link |
01:17:14.400
to see what's the next problem we can tackle
link |
01:17:17.400
in the fusion area.
link |
01:17:19.360
So, another fascinating place in a paper titled,
link |
01:17:23.080
Pushing the Frontiers of Density Functionals
link |
01:17:25.120
by Solving the Fractional Electron Problem.
link |
01:17:27.520
So, you're taking on modeling and simulating
link |
01:17:30.880
the quantum mechanical behavior of electrons.
link |
01:17:33.320
Yes.
link |
01:17:36.040
Can you explain this work and can AI model
link |
01:17:39.240
and simulate arbitrary quantum mechanical systems
link |
01:17:41.560
in the future?
link |
01:17:42.400
Yeah, so this is another problem I've had my eye on
link |
01:17:44.240
for a decade or more,
link |
01:17:47.160
which is sort of simulating the properties of electrons.
link |
01:17:51.200
If you can do that, you can basically describe
link |
01:17:54.280
how elements and materials and substances work.
link |
01:17:58.040
So, it's kind of like fundamental
link |
01:18:00.040
if you want to advance material science.
link |
01:18:02.840
And we have Schrodinger's equation
link |
01:18:05.240
and then we have approximations
link |
01:18:06.480
to that density functional theory.
link |
01:18:08.400
These things are famous.
link |
01:18:10.560
And people try and write approximations
link |
01:18:13.200
to these functionals and kind of come up
link |
01:18:17.040
with descriptions of the electron clouds,
link |
01:18:19.880
where they're going to go,
link |
01:18:20.720
how they're going to interact
link |
01:18:22.120
when you put two elements together.
link |
01:18:24.240
And what we try to do is learn a simulation,
link |
01:18:27.680
learn a functional that will describe more chemistry,
link |
01:18:30.560
types of chemistry.
link |
01:18:31.760
So, until now, you can run expensive simulations,
link |
01:18:35.560
but then you can only simulate very small molecules,
link |
01:18:38.760
very simple molecules.
link |
01:18:40.160
We would like to simulate large materials.
link |
01:18:43.080
And so, today there's no way of doing that.
link |
01:18:45.760
And we're building up towards building functionals
link |
01:18:48.560
that approximate Schrodinger's equation
link |
01:18:51.240
and then allow you to describe what the electrons are doing.
link |
01:18:55.600
And all material sort of science
link |
01:18:57.480
and material properties are governed by the electrons
link |
01:18:59.920
and how they interact.
link |
01:19:01.360
So, have a good summarization of the simulation
link |
01:19:05.840
through the functional,
link |
01:19:08.720
but one that is still close
link |
01:19:11.360
to what the actual simulation would come out with.
link |
01:19:13.200
So, how difficult is that task?
link |
01:19:16.720
What's involved in that task?
link |
01:19:17.760
Is it running those complicated simulations
link |
01:19:20.720
and learning the task of mapping
link |
01:19:23.280
from the initial conditions
link |
01:19:24.560
and the parameters of the simulation,
link |
01:19:26.400
learning what the functional would be?
link |
01:19:27.720
Yeah.
link |
01:19:28.560
So, it's pretty tricky.
link |
01:19:29.440
And we've done it with,
link |
01:19:31.320
the nice thing is we can run a lot of the simulations,
link |
01:19:35.440
the molecular dynamic simulations on our compute clusters.
link |
01:19:39.080
And so, that generates a lot of data.
link |
01:19:40.840
So, in this case, the data is generated.
link |
01:19:42.800
So, we like those sort of systems and that's why we use games.
link |
01:19:45.880
It's simulated, generated data.
link |
01:19:48.480
And we can kind of create as much of it as we want, really.
link |
01:19:51.160
And just let's leave some,
link |
01:19:53.280
if any computers are free in the cloud,
link |
01:19:55.280
we just run, we run some of these calculations, right?
link |
01:19:57.680
Compute cluster calculation.
link |
01:19:59.360
I like how the free compute time
link |
01:20:01.080
is used up on quantum mechanics.
link |
01:20:02.200
Yeah, quantum mechanics, exactly.
link |
01:20:03.560
Simulations and protein simulations and other things.
link |
01:20:06.280
And so, when you're not searching on YouTube
link |
01:20:09.880
for free video, cat videos,
link |
01:20:11.360
we're using those computers usefully in quantum chemistry.
link |
01:20:13.960
It's the idea.
link |
01:20:14.800
Finally.
link |
01:20:15.640
And putting them to good use.
link |
01:20:17.000
And then, yeah, and then all of that computational data
link |
01:20:19.760
that's generated,
link |
01:20:20.840
we can then try and learn the functionals from that,
link |
01:20:23.480
which of course are way more efficient
link |
01:20:25.640
once we learn the functional
link |
01:20:27.080
than running those simulations would be.
link |
01:20:30.560
Do you think one day AI may allow us
link |
01:20:33.120
to do something like basically crack open physics?
link |
01:20:36.360
So, do something like travel faster than the speed of light?
link |
01:20:39.520
My ultimate aim is always being with AI
link |
01:20:41.600
is the reason I am personally working on AI
link |
01:20:45.560
for my whole life, it was to build a tool
link |
01:20:48.200
to help us understand the universe.
link |
01:20:50.360
So, I wanted to, and that means physics, really,
link |
01:20:53.800
and the nature of reality.
link |
01:20:54.920
So, I don't think we have systems
link |
01:20:58.000
that are capable of doing that yet,
link |
01:20:59.400
but when we get towards AGI,
link |
01:21:01.000
I think that's one of the first things
link |
01:21:02.920
I think we should apply AGI to.
link |
01:21:05.320
I would like to test the limits of physics
link |
01:21:07.160
and our knowledge of physics.
link |
01:21:08.600
There's so many things we don't know.
link |
01:21:10.080
This is one thing I find fascinating about science.
link |
01:21:12.320
And as a huge proponent of the scientific method
link |
01:21:15.080
as being one of the greatest ideas humanity has ever had
link |
01:21:17.880
and allowed us to progress with our knowledge,
link |
01:21:20.160
but I think as a true scientist,
link |
01:21:22.000
I think what you find is the more you find out,
link |
01:21:25.200
the more you realize we don't know.
link |
01:21:27.040
And I always think that it's surprising
link |
01:21:29.880
that more people aren't troubled.
link |
01:21:31.880
Every night I think about all these things
link |
01:21:34.000
we interact with all the time,
link |
01:21:35.240
that we have no idea how they work.
link |
01:21:36.880
Time, consciousness, gravity, life, we can't,
link |
01:21:41.440
I mean, these are all the fundamental things of nature.
link |
01:21:43.840
I think the way we don't really know what they are.
link |
01:21:47.320
To live life, we pin certain assumptions on them
link |
01:21:51.480
and kind of treat our assumptions as if they're a fact.
link |
01:21:55.240
That allows us to sort of box them off somehow.
link |
01:21:57.560
Yeah, box them off somehow.
link |
01:21:59.000
But the reality is when you think of time,
link |
01:22:02.320
you should remind yourself,
link |
01:22:03.560
you should take it off the shelf
link |
01:22:06.760
and realize like, no, we have a bunch of assumptions.
link |
01:22:09.040
There's still a lot of, there's even now a lot of debate.
link |
01:22:11.520
There's a lot of uncertainty about exactly what is time.
link |
01:22:15.520
Is there an error of time?
link |
01:22:17.480
You know, there's a lot of fundamental questions
link |
01:22:19.480
that you can't just make assumptions about.
link |
01:22:21.160
And maybe AI allows you to not put anything on the shelf.
link |
01:22:27.680
Yeah.
link |
01:22:28.520
Not make any hard assumptions
link |
01:22:30.200
and really open it up and see what's.
link |
01:22:32.080
Exactly, I think we should be truly open minded about that.
link |
01:22:34.640
And exactly that, not be dogmatic to a particular theory.
link |
01:22:39.040
It'll also allow us to build better tools,
link |
01:22:41.960
experimental tools eventually,
link |
01:22:44.400
that can then test certain theories
link |
01:22:46.280
that may not be testable today.
link |
01:22:48.080
Things about like what we spoke about at the beginning
link |
01:22:51.240
about the computational nature of the universe.
link |
01:22:53.520
How one might, if that was true,
link |
01:22:55.320
how one might go about testing that, right?
link |
01:22:57.360
And how much, you know, there are people
link |
01:22:59.840
who've conjectured people like Scott Aaronson and others
link |
01:23:02.520
about, you know, how much information
link |
01:23:04.720
can a specific plank unit of space and time
link |
01:23:08.040
contain, right?
link |
01:23:09.200
So one might be able to think about testing those ideas
link |
01:23:11.960
if you had AI helping you build
link |
01:23:15.360
some new exquisite experimental tools.
link |
01:23:19.400
This is what I imagine that, you know,
link |
01:23:20.960
many decades from now we'll be able to do.
link |
01:23:23.120
And what kind of questions can be answered
link |
01:23:25.840
through running a simulation of them?
link |
01:23:28.840
So there's a bunch of physics simulations
link |
01:23:30.760
you can imagine that could be run
link |
01:23:32.600
in some kind of efficient way,
link |
01:23:35.760
much like you're doing in the quantum simulation work.
link |
01:23:40.320
And perhaps even the origin of life.
link |
01:23:42.160
So figuring out how going even back
link |
01:23:45.160
before the work of AlphaFold begins
link |
01:23:47.640
of how this whole thing emerges from a rock.
link |
01:23:52.640
Yes.
link |
01:23:53.480
From a static thing.
link |
01:23:54.320
What do you think AI will allow us to,
link |
01:23:57.040
is that something you have your eye on?
link |
01:23:58.920
It's trying to understand the origin of life.
link |
01:24:01.560
First of all, yourself, what do you think,
link |
01:24:06.320
how the heck did life originate on Earth?
link |
01:24:08.760
Yeah, well, maybe I'll come to that in a second,
link |
01:24:11.120
but I think the ultimate use of AI
link |
01:24:13.800
is to kind of use it to accelerate science to the maximum.
link |
01:24:18.120
So I think of it a little bit
link |
01:24:21.040
like the tree of all knowledge.
link |
01:24:22.600
If you imagine that's all the knowledge there is
link |
01:24:24.160
in the universe to attain.
link |
01:24:25.840
And we sort of barely scratched the surface of that so far.
link |
01:24:29.320
And even though we've done pretty well
link |
01:24:31.960
since the enlightenment, right, as humanity.
link |
01:24:34.320
And I think AI will turbocharge all of that,
link |
01:24:36.840
like we've seen with AlphaFold.
link |
01:24:38.600
And I want to explore as much of that tree of knowledge
link |
01:24:41.400
as is possible to do.
link |
01:24:42.920
And I think that involves AI helping us
link |
01:24:46.400
with understanding or finding patterns,
link |
01:24:49.680
but also potentially designing and building new tools,
link |
01:24:52.200
experimental tools.
link |
01:24:53.600
So I think that's all,
link |
01:24:56.040
and also running simulations and learning simulations,
link |
01:24:58.920
all of that we're sort of doing at a baby steps level here.
link |
01:25:05.000
But I can imagine that in the decades to come
link |
01:25:08.560
as what's the full flourishing of that line of thinking.
link |
01:25:12.920
It's gonna be truly incredible, I would say.
link |
01:25:15.160
If I visualized this tree of knowledge,
link |
01:25:17.320
something tells me that that tree of knowledge for humans
link |
01:25:20.840
is much smaller in the set of all possible trees
link |
01:25:24.440
of knowledge, it's actually quite small
link |
01:25:26.600
given our cognitive limitations,
link |
01:25:31.480
limited cognitive capabilities,
link |
01:25:33.680
that even with the tools we build,
link |
01:25:35.720
we still won't be able to understand a lot of things.
link |
01:25:38.120
And that's perhaps what nonhuman systems
link |
01:25:41.160
might be able to reach farther, not just as tools,
link |
01:25:44.920
but in themselves understanding something
link |
01:25:47.200
that they can bring back.
link |
01:25:48.480
Yeah, it could well be.
link |
01:25:50.200
So, I mean, there's so many things
link |
01:25:51.800
that are sort of encapsulated in what you just said there.
link |
01:25:55.000
I think first of all, there's two different things.
link |
01:25:58.320
There's like, what do we understand today?
link |
01:26:00.560
What could the human mind understand?
link |
01:26:02.680
And what is the totality of what is there to be understood?
link |
01:26:06.400
And so there's three concentric,
link |
01:26:08.640
you can think of them as three larger and larger trees
link |
01:26:10.720
or exploring more branches of that tree.
link |
01:26:12.880
And I think with AI, we're gonna explore that whole lot.
link |
01:26:15.960
Now, the question is, if you think about
link |
01:26:19.120
what is the totality of what could be understood,
link |
01:26:22.680
there may be some fundamental physics reasons
link |
01:26:24.800
why certain things can't be understood,
link |
01:26:26.280
like what's outside a simulation or outside the universe.
link |
01:26:29.000
Maybe it's not understandable from within the universe.
link |
01:26:32.320
So there may be some hard constraints like that.
link |
01:26:34.840
It could be smaller constraints,
link |
01:26:36.000
like we think of space time as fundamental.
link |
01:26:40.520
Our human brains are really used to this idea
link |
01:26:42.880
of a three dimensional world with time, maybe.
link |
01:26:46.040
But our tools could go beyond that.
link |
01:26:47.760
They wouldn't have that limitation necessarily.
link |
01:26:49.760
They could think in 11 dimensions, 12 dimensions,
link |
01:26:51.760
whatever is needed.
link |
01:26:52.920
But we could still maybe understand that
link |
01:26:55.640
in several different ways.
link |
01:26:56.720
The example I always give is,
link |
01:26:59.040
when I play Garry Kasparov for speed chess,
link |
01:27:01.400
or we've talked about chess and these kinds of things,
link |
01:27:04.400
you know, if you're reasonably good at chess,
link |
01:27:07.520
you can't come up with the move Garry comes up with
link |
01:27:11.200
in his move, but he can explain it to you.
link |
01:27:13.320
And you can understand.
link |
01:27:14.160
And you can understand post hoc the reasoning.
link |
01:27:16.720
So I think there's an even further level of like,
link |
01:27:19.400
well, maybe you couldn't have invented that thing,
link |
01:27:21.640
but going back to using language again,
link |
01:27:24.320
perhaps you can understand and appreciate that.
link |
01:27:27.040
Same way that you can appreciate, you know,
link |
01:27:28.920
Vivaldi or Mozart or something without,
link |
01:27:31.120
you can appreciate the beauty of that
link |
01:27:32.680
without being able to construct it yourself, right?
link |
01:27:35.800
Invent the music yourself.
link |
01:27:37.400
So I think we see this in all forms of life.
link |
01:27:39.280
So it will be that times, you know, a million,
link |
01:27:42.440
but you can imagine also one sign of intelligence
link |
01:27:45.800
is the ability to explain things clearly and simply, right?
link |
01:27:49.320
You know, people like Richard Feynman,
link |
01:27:50.400
another one of my old time heroes used to say that, right?
link |
01:27:52.400
If you can't, you know, if you can explain it
link |
01:27:54.480
something simply, then that's the best sign,
link |
01:27:57.360
a complex topic simply,
link |
01:27:58.640
then that's one of the best signs of you understanding it.
link |
01:28:00.680
Yeah.
link |
01:28:01.520
I can see myself talking trash in the AI system in that way.
link |
01:28:04.600
Yes.
link |
01:28:05.680
It gets frustrated how dumb I am
link |
01:28:07.800
and trying to explain something to me.
link |
01:28:09.880
I was like, well, that means you're not intelligent
link |
01:28:11.600
because if you were intelligent,
link |
01:28:12.720
you'd be able to explain it simply.
link |
01:28:14.440
Yeah, of course, you know, there's also the other option.
link |
01:28:16.720
Of course, we could enhance ourselves and with our devices,
link |
01:28:19.560
we are already sort of symbiotic with our compute devices,
link |
01:28:23.120
right, with our phones and other things.
link |
01:28:24.600
And, you know, there's stuff like Neuralink and Xceptra
link |
01:28:27.120
that could advance that further.
link |
01:28:30.000
So I think there's lots of really amazing possibilities
link |
01:28:33.880
that I could foresee from here.
link |
01:28:35.360
Well, let me ask you some wild questions.
link |
01:28:37.040
So out there looking for friends,
link |
01:28:39.920
do you think there's a lot of alien civilizations out there?
link |
01:28:43.120
So I guess this also goes back
link |
01:28:44.960
to your origin of life question too,
link |
01:28:46.640
because I think that that's key.
link |
01:28:48.240
My personal opinion, looking at all this,
link |
01:28:51.360
and, you know, it's one of my hobbies, physics, I guess.
link |
01:28:53.680
So, you know, it's something I think about a lot
link |
01:28:56.880
and talk to a lot of experts on and read a lot of books on.
link |
01:29:00.760
And I think my feeling currently is that we are alone.
link |
01:29:05.280
I think that's the most likely scenario
link |
01:29:07.160
given what evidence we have.
link |
01:29:08.800
So, and the reasoning is I think that, you know,
link |
01:29:13.160
we've tried since things like SETI program
link |
01:29:16.120
and I guess since the dawning of the space age,
link |
01:29:19.840
we've, you know, had telescopes,
link |
01:29:21.240
open radio telescopes and other things.
link |
01:29:23.280
And if you think about and try to detect signals,
link |
01:29:27.280
now, if you think about the evolution of humans on earth,
link |
01:29:30.120
we could have easily been a million years ahead
link |
01:29:33.960
of our time now or million years behind,
link |
01:29:36.280
right, easily with just some slightly different quirk
link |
01:29:39.440
thing happening hundreds of thousands of years ago.
link |
01:29:42.120
You know, things could have been slightly different
link |
01:29:43.640
if the meteor would hit the dinosaurs a million years earlier,
link |
01:29:46.200
maybe things would have evolved.
link |
01:29:48.080
We'd be a million years ahead of where we are now.
link |
01:29:50.920
So what that means is if you imagine where humanity will be
link |
01:29:54.080
in a few hundred years, let alone a million years,
link |
01:29:56.720
especially if we hopefully, you know,
link |
01:29:59.840
solve things like climate change and other things,
link |
01:30:02.200
and we continue to flourish and we build things like AI
link |
01:30:05.640
and we do space traveling and all of the stuff
link |
01:30:07.920
that humans have dreamed of forever, right?
link |
01:30:10.800
And sci fi is talked about forever.
link |
01:30:14.360
We will be spreading across the stars, right?
link |
01:30:16.760
And von Neumann famously calculated, you know,
link |
01:30:19.240
it would only take about a million years
link |
01:30:20.800
if you sent out von Neumann probes to the nearest,
link |
01:30:23.240
you know, the nearest other solar systems.
link |
01:30:26.200
And then all they did was build two more versions
link |
01:30:29.040
of themselves and sent those two out
link |
01:30:30.440
to the next nearest systems.
link |
01:30:32.240
You know, within a million years,
link |
01:30:33.480
I think you would have one of these probes
link |
01:30:35.040
in every system in the galaxy.
link |
01:30:36.920
So it's not actually in cosmological time.
link |
01:30:40.040
That's actually a very short amount of time.
link |
01:30:42.080
So, and you know, people like Dyson have thought
link |
01:30:44.600
about constructing Dyson spheres around stars
link |
01:30:47.280
to collect all the energy coming out of the star.
link |
01:30:49.800
You know, there would be constructions like that
link |
01:30:51.800
would be visible across space,
link |
01:30:54.120
probably even across a galaxy.
link |
01:30:56.000
So, and then, you know, if you think about
link |
01:30:57.920
all of our radio, television emissions
link |
01:31:00.760
that have gone out since the, you know, 30s and 40s,
link |
01:31:05.120
imagine a million years of that.
link |
01:31:06.720
And now hundreds of civilizations doing that.
link |
01:31:10.000
When we opened our ears at the point
link |
01:31:12.200
we got technologically sophisticated enough
link |
01:31:14.840
in the space age,
link |
01:31:15.880
we should have heard a cacophony of voices.
link |
01:31:19.120
We should have joined that cacophony of voices.
link |
01:31:20.920
And what we did, we opened our ears and we heard nothing.
link |
01:31:24.480
And many people who argue that there are aliens
link |
01:31:27.120
would say, well, we haven't really done
link |
01:31:28.800
exhaustive search yet.
link |
01:31:29.920
And maybe we're looking in the wrong bands
link |
01:31:31.880
and we've got the wrong devices
link |
01:31:33.760
and we wouldn't notice what an alien form was like
link |
01:31:36.080
because it'd be so different to what we're used to.
link |
01:31:38.280
But, you know, I don't really buy that,
link |
01:31:40.640
that it shouldn't be as difficult as that.
link |
01:31:42.640
Like, I think we've searched enough.
link |
01:31:44.320
There should be everywhere.
link |
01:31:45.680
If it was, yeah, it should be everywhere.
link |
01:31:47.280
We should see Dyson spheres being put up,
link |
01:31:49.240
sun's blinking in and out.
link |
01:31:50.600
You know, there should be a lot of evidence
link |
01:31:52.000
for those things.
link |
01:31:52.920
And then there are other people who argue,
link |
01:31:54.160
well, the sort of safari view of like,
link |
01:31:56.000
well, we're a primitive species still
link |
01:31:57.840
because we're not space faring yet.
link |
01:31:59.400
And we're, you know, there's some kind of global,
link |
01:32:01.400
like universal rule not to interfere,
link |
01:32:03.360
you know, Star Trek rule.
link |
01:32:04.600
But like, look, we can't even coordinate humans
link |
01:32:07.360
to deal with climate change and we're one species.
link |
01:32:10.040
What is the chance that of all of these different
link |
01:32:12.400
human civilization, you know, alien civilizations,
link |
01:32:14.800
they would have the same priorities
link |
01:32:16.760
and agree across these kinds of matters.
link |
01:32:20.200
And even if that was true
link |
01:32:21.840
and we were in some sort of safari for our own good,
link |
01:32:25.040
to me, that's not much different
link |
01:32:26.360
from the simulation hypothesis
link |
01:32:27.640
because what does it mean, the simulation hypothesis?
link |
01:32:29.880
I think in its most fundamental level,
link |
01:32:31.360
it means what we're seeing is not quite reality, right?
link |
01:32:34.960
It's something, there's something more deeper underlying it,
link |
01:32:37.760
maybe computational.
link |
01:32:39.120
Now, if we were in a sort of safari park
link |
01:32:42.600
and everything we were seeing was a hologram
link |
01:32:44.440
and it was projected by the aliens or whatever,
link |
01:32:46.520
that to me is not much different
link |
01:32:47.840
than thinking we're inside of another universe
link |
01:32:50.280
because we still can't see true reality, right?
link |
01:32:53.160
I mean, there's other explanations.
link |
01:32:55.120
It could be that the way they're communicating
link |
01:32:58.000
is just fundamentally different,
link |
01:32:59.280
that we're too dumb to understand the much better methods
link |
01:33:02.440
of communication they have.
link |
01:33:03.840
It could be, I mean, it's silly to say,
link |
01:33:06.600
but our own thoughts could be the methods
link |
01:33:09.960
by which they're communicating.
link |
01:33:11.200
Like the place from which our ideas,
link |
01:33:13.240
writers talk about this, like the muse.
link |
01:33:15.160
Yeah.
link |
01:33:17.120
I mean, it sounds like very kind of wild,
link |
01:33:20.880
but it could be thoughts.
link |
01:33:22.160
It could be some interactions with our mind
link |
01:33:24.600
that we think are originating from us
link |
01:33:27.840
is actually something that is coming
link |
01:33:31.440
from other life forms elsewhere.
link |
01:33:33.040
Consciousness itself might be that.
link |
01:33:34.880
It could be, but I don't see any sensible argument
link |
01:33:37.360
to the why would all of the alien species
link |
01:33:40.560
behave in this way?
link |
01:33:41.600
Yeah, some of them will be more primitive.
link |
01:33:43.200
They will be close to our level.
link |
01:33:44.920
There should be a whole sort of normal distribution
link |
01:33:47.760
of these things, right?
link |
01:33:48.680
Some would be aggressive.
link |
01:33:49.640
Some would be curious.
link |
01:33:52.120
Others would be very historical and philosophical
link |
01:33:55.560
because maybe they're a million years older than us,
link |
01:33:58.080
but it's not, it shouldn't be like,
link |
01:34:00.160
I mean, one alien civilization might be like that,
link |
01:34:03.000
communicating thoughts and others,
link |
01:34:04.200
but I don't see why potentially the hundreds there should be
link |
01:34:07.720
would be uniform in this way, right?
link |
01:34:10.040
It could be a violent dictatorship that the people,
link |
01:34:13.040
the alien civilizations that become successful
link |
01:34:20.560
gain the ability to be destructive,
link |
01:34:23.080
an order of magnitude more destructive,
link |
01:34:26.000
but of course the sad thought,
link |
01:34:29.880
well, either humans are very special.
link |
01:34:32.640
We took a lot of leaps that arrived
link |
01:34:35.480
at what it means to be human.
link |
01:34:38.600
There's a question there, which was the hardest,
link |
01:34:41.160
which was the most special,
link |
01:34:42.720
but also if others have reached this level
link |
01:34:45.200
and maybe many others have reached this level,
link |
01:34:47.680
the great filter that prevented them from going farther
link |
01:34:52.680
to becoming a multi planetary species
link |
01:34:54.800
or reaching out into the stars.
link |
01:34:57.520
And those are really important questions for us,
link |
01:34:59.960
whether there's other alien civilizations out there or not,
link |
01:35:04.720
this is very useful for us to think about.
link |
01:35:06.960
If we destroy ourselves, how will we do it?
link |
01:35:10.240
And how easy is it to do?
link |
01:35:11.960
Yeah, well, these are big questions
link |
01:35:14.160
and I've thought about these a lot,
link |
01:35:15.320
but the interesting thing is that if we're alone,
link |
01:35:19.600
that's somewhat comforting from the great filter perspective
link |
01:35:22.000
because it probably means the great filters were passed us.
link |
01:35:25.240
And I'm pretty sure they are.
link |
01:35:26.240
So going back to your origin of life question,
link |
01:35:29.040
there are some incredible things
link |
01:35:30.560
that no one knows how happened,
link |
01:35:31.760
like obviously the first life form from chemical soup,
link |
01:35:35.240
that seems pretty hard,
link |
01:35:36.800
but I would guess the multicellular,
link |
01:35:38.720
I wouldn't be that surprised if we saw single cell
link |
01:35:42.120
sort of life forms elsewhere, bacteria type things,
link |
01:35:45.440
but multicellular life seems incredibly hard,
link |
01:35:48.000
that step of capturing mitochondria
link |
01:35:50.200
and then sort of using that as part of yourself,
link |
01:35:53.120
you know, when you've just eaten it.
link |
01:35:53.960
Would you say that's the biggest, the most,
link |
01:35:57.560
like if you had to choose one sort of,
link |
01:36:01.400
Hitchhiker's Galaxy, one sentence summary of like,
link |
01:36:04.400
oh, those clever creatures did this,
link |
01:36:07.280
that would be the multicellular.
link |
01:36:08.280
I think that was probably the one that's the biggest.
link |
01:36:10.600
I mean, there's a great book
link |
01:36:11.440
called The 10 Great Inventions of Evolution by Nick Lane,
link |
01:36:14.760
and he speculates on 10 of these, you know,
link |
01:36:17.440
what could be great filters.
link |
01:36:19.800
I think that's one.
link |
01:36:21.000
I think the advent of intelligence
link |
01:36:23.880
and conscious intelligence and in order, you know,
link |
01:36:26.360
to us to be able to do science and things like that
link |
01:36:28.600
is huge as well.
link |
01:36:29.880
I mean, it's only evolved once as far as, you know,
link |
01:36:32.840
in Earth history.
link |
01:36:34.880
So that would be a later candidate,
link |
01:36:37.160
but there's certainly for the early candidates,
link |
01:36:39.160
I think multicellular life forms is huge.
link |
01:36:41.440
By the way, what it's interesting to ask you,
link |
01:36:43.560
if you can hypothesize about
link |
01:36:45.760
what is the origin of intelligence?
link |
01:36:48.000
Is it that we started cooking meat over fire?
link |
01:36:53.640
Is it that we somehow figured out
link |
01:36:55.520
that we could be very powerful when we started collaborating?
link |
01:36:58.120
So cooperation between our ancestors
link |
01:37:03.560
so that we can overthrow the alpha male.
link |
01:37:07.040
What is it, Richard?
link |
01:37:07.880
I talked to Richard Ranham,
link |
01:37:08.920
who thinks we're all just beta males
link |
01:37:10.760
who figured out how to collaborate to defeat the one,
link |
01:37:13.840
the dictator, the authoritarian alpha male
link |
01:37:16.360
that controlled the tribe.
link |
01:37:18.360
Is there other explanation?
link |
01:37:20.120
Was there 2001 Space Odyssey type of monolith
link |
01:37:24.080
that came down to Earth?
link |
01:37:25.280
Well, I think all of those things
link |
01:37:27.480
you suggested are good candidates,
link |
01:37:28.640
fire and cooking, right?
link |
01:37:30.680
So that's clearly important for energy efficiency,
link |
01:37:35.520
cooking our meat and then being able to be more efficient
link |
01:37:39.600
about eating it and consuming the energy.
link |
01:37:42.840
I think that's huge and then utilizing fire and tools
link |
01:37:45.720
I think you're right about the tribal cooperation aspects
link |
01:37:48.640
and probably language is part of that
link |
01:37:51.040
because probably that's what allowed us
link |
01:37:52.400
to outcompete Neanderthals
link |
01:37:53.680
and perhaps less cooperative species.
link |
01:37:56.160
So that may be the case.
link |
01:37:58.760
Tool making, spears, axes, I think that let us,
link |
01:38:02.400
I mean, I think it's pretty clear now
link |
01:38:03.920
that humans were responsible
link |
01:38:05.080
for a lot of the extinctions of megafauna,
link |
01:38:07.840
especially in the Americas when humans arrived.
link |
01:38:10.840
So you can imagine once you discover tool usage
link |
01:38:14.440
how powerful that would have been
link |
01:38:15.800
and how scary for animals.
link |
01:38:17.520
So I think all of those could have been explanations for it.
link |
01:38:20.720
The interesting thing is that it's a bit
link |
01:38:22.760
like general intelligence too,
link |
01:38:24.080
is it's very costly to begin with to have a brain
link |
01:38:28.040
and especially a general purpose brain
link |
01:38:29.520
rather than a special purpose one
link |
01:38:30.920
because the amount of energy our brains use,
link |
01:38:32.320
I think it's like 20% of the body's energy
link |
01:38:34.400
and it's massive and even your thinking chest,
link |
01:38:36.680
one of the funny things that we used to say
link |
01:38:39.000
is it's as much as a racing driver uses
link |
01:38:41.560
for a whole Formula One race,
link |
01:38:43.560
just playing a game of serious high level chess,
link |
01:38:46.360
which you wouldn't think just sitting there
link |
01:38:49.280
because the brain's using so much energy.
link |
01:38:52.040
So in order for an animal, an organism to justify that,
link |
01:38:54.760
there has to be a huge payoff.
link |
01:38:57.840
And the problem with half a brain
link |
01:39:00.280
or half intelligence, say an IQs of like a monkey brain,
link |
01:39:06.720
it's not clear you can justify that evolutionary
link |
01:39:10.240
until you get to the human level brain.
link |
01:39:12.440
And so, but how do you do that jump?
link |
01:39:14.720
It's very difficult,
link |
01:39:15.560
which is why I think it has only been done once
link |
01:39:17.120
from the sort of specialized brains that you see in animals
link |
01:39:19.800
to this sort of general purpose,
link |
01:39:22.480
chewing powerful brains that humans have
link |
01:39:26.200
and which allows us to invent the modern world.
link |
01:39:29.800
And it takes a lot to cross that barrier.
link |
01:39:33.600
And I think we've seen the same with AI systems,
link |
01:39:35.600
which is that maybe until very recently,
link |
01:39:38.160
it's always been easier to craft a specific solution
link |
01:39:40.880
to a problem like chess than it has been
link |
01:39:43.040
to build a general learning system
link |
01:39:44.480
that could potentially do many things.
link |
01:39:46.280
Cause initially that system will be way worse
link |
01:39:49.480
than less efficient than the specialized system.
link |
01:39:52.120
So one of the interesting quirks of the human mind
link |
01:39:55.880
of this evolved system is that it appears to be conscious.
link |
01:40:01.320
This thing that we don't quite understand,
link |
01:40:02.920
but it seems very special is ability
link |
01:40:07.360
to have a subjective experience
link |
01:40:08.760
that it feels like something to eat a cookie,
link |
01:40:12.280
the deliciousness of it or see a color
link |
01:40:14.320
and that kind of stuff.
link |
01:40:15.560
Do you think in order to solve intelligence,
link |
01:40:17.960
we also need to solve consciousness along the way?
link |
01:40:20.680
Do you think AGI systems need to have consciousness
link |
01:40:23.920
in order to be truly intelligent?
link |
01:40:28.000
Yeah, we thought about this a lot actually.
link |
01:40:29.640
And I think that my guess is that consciousness
link |
01:40:33.440
and intelligence are double dissociable.
link |
01:40:35.800
So you can have one without the other both ways.
link |
01:40:38.360
And I think you can see that with consciousness
link |
01:40:40.920
in that I think some animals and pets,
link |
01:40:44.160
if you have a pet dog or something like that,
link |
01:40:46.240
you can see some of the higher animals and dolphins,
link |
01:40:48.560
things like that have self awareness
link |
01:40:51.680
and are very sociable, seem to dream.
link |
01:40:57.360
A lot of the traits one would regard
link |
01:40:59.000
as being kind of conscious and self aware,
link |
01:41:02.800
but yet they're not that smart, right?
link |
01:41:05.080
So they're not that intelligent
link |
01:41:06.320
by say IQ standards or something like that.
link |
01:41:08.920
Yeah, it's also possible that our understanding
link |
01:41:11.080
of intelligence is flawed, like putting an IQ to it.
link |
01:41:14.920
Maybe the thing that a dog can do
link |
01:41:17.360
is actually gone very far along the path of intelligence
link |
01:41:20.640
and we humans are just able to play chess
link |
01:41:23.240
and maybe write poems.
link |
01:41:24.840
Right, but if we go back to the idea of AGI
link |
01:41:27.040
and general intelligence, dogs are very specialized, right?
link |
01:41:29.480
Most animals are pretty specialized.
link |
01:41:30.920
They can be amazing at what they do,
link |
01:41:32.360
but they're like kind of elite sports people or something,
link |
01:41:35.600
right, so they do one thing extremely well
link |
01:41:38.040
because their entire brain is optimized.
link |
01:41:40.080
They have somehow convinced the entirety
link |
01:41:41.880
of the human population to feed them and service them.
link |
01:41:44.520
So in some way they're controlling.
link |
01:41:46.400
Yes, exactly.
link |
01:41:47.240
Well, we co evolved to some crazy degree, right?
link |
01:41:50.120
Including the way the dogs even wag their tails
link |
01:41:53.800
and twitch their noses, right?
link |
01:41:55.160
We find inextricably cute.
link |
01:41:58.640
But I think you can also see intelligence on the other side.
link |
01:42:01.840
So systems like artificial systems
link |
01:42:03.800
that are amazingly smart at certain things
link |
01:42:07.240
like maybe playing go and chess and other things,
link |
01:42:09.800
but they don't feel at all in any shape or form conscious
link |
01:42:13.440
in the way that you do to me or I do to you.
link |
01:42:17.240
And I think actually building AI
link |
01:42:21.440
is these intelligent constructs
link |
01:42:24.200
is one of the best ways to explore
link |
01:42:25.920
the mystery of consciousness, to break it down
link |
01:42:28.000
because we're gonna have devices
link |
01:42:31.200
that are pretty smart at certain things
link |
01:42:34.440
or capable at certain things,
link |
01:42:36.200
but potentially won't have any semblance
link |
01:42:39.160
of self awareness or other things.
link |
01:42:40.800
And in fact, I would advocate if there's a choice,
link |
01:42:43.880
building systems in the first place,
link |
01:42:45.680
AI systems that are not conscious to begin with
link |
01:42:48.640
are just tools until we understand them better
link |
01:42:52.440
and the capabilities better.
link |
01:42:53.960
So on that topic, just not as the CEO of DeepMind,
link |
01:42:58.320
just as a human being, let me ask you
link |
01:43:00.880
about this one particular anecdotal evidence
link |
01:43:03.480
of the Google engineer who made a comment
link |
01:43:07.080
or believed that there's some aspect of a language model,
link |
01:43:11.800
the Lambda language model that exhibited sentience.
link |
01:43:15.960
So you said you believe there might be a responsibility
link |
01:43:18.440
to build systems that are not sentient.
link |
01:43:21.120
And this experience of a particular engineer,
link |
01:43:23.560
I think I'd love to get your general opinion
link |
01:43:25.880
on this kind of thing, but I think it will happen
link |
01:43:28.000
more and more and more, which not when engineers,
link |
01:43:31.480
but when people out there that don't have
link |
01:43:33.120
an engineering background start interacting
link |
01:43:34.760
with increasingly intelligent systems,
link |
01:43:37.120
we anthropomorphize them.
link |
01:43:38.960
They start to have deep, impactful interactions with us
link |
01:43:44.680
in a way that we miss them when they're gone.
link |
01:43:47.920
And we sure as heck feel like they're living entities,
link |
01:43:51.960
self aware entities, and maybe even
link |
01:43:54.200
we project sentience onto them.
link |
01:43:55.960
So what's your thought about this particular system?
link |
01:44:01.320
Have you ever met a language model that's sentient?
link |
01:44:04.600
No, no.
link |
01:44:06.320
What do you make of the case of when you kind of feel
link |
01:44:10.200
that there's some elements of sentience to the system?
link |
01:44:12.920
Yeah, so this is an interesting question
link |
01:44:15.040
and obviously a very fundamental one.
link |
01:44:17.760
So the first thing to say is I think that none
link |
01:44:20.280
of the systems we have today, I would say,
link |
01:44:22.200
even have one iota of semblance
link |
01:44:25.080
of consciousness or sentience.
link |
01:44:26.320
That's my personal feeling interacting with them every day.
link |
01:44:29.720
So I think this way premature to be discussing
link |
01:44:32.400
what that engineer talked about.
link |
01:44:34.160
I think at the moment it's more of a projection
link |
01:44:36.480
of the way our own minds work,
link |
01:44:37.840
which is to see sort of purpose and direction
link |
01:44:43.120
in almost anything that we, you know,
link |
01:44:44.600
our brains are trained to interpret agency,
link |
01:44:48.200
basically in things, even inanimate things sometimes.
link |
01:44:52.280
And of course with a language system,
link |
01:44:54.880
because language is so fundamental to intelligence,
link |
01:44:57.080
that's going to be easy for us to anthropomorphize that.
link |
01:45:00.440
I mean, back in the day, even the first, you know,
link |
01:45:03.840
the dumbest sort of template chatbots ever,
link |
01:45:05.800
Eliza and the ilk of the original chatbots
link |
01:45:09.200
back in the sixties fooled some people
link |
01:45:11.160
under certain circumstances, right?
link |
01:45:12.600
It pretended to be a psychologist.
link |
01:45:14.040
So just basically rabbit back to you
link |
01:45:16.080
the same question you asked it back to you.
link |
01:45:19.240
And some people believe that.
link |
01:45:21.320
So I don't think we can, this is why I think
link |
01:45:23.280
the Turing test is a little bit flawed as a formal test
link |
01:45:25.440
because it depends on the sophistication of the judge,
link |
01:45:29.240
whether or not they are qualified to make that distinction.
link |
01:45:33.280
So I think we should talk to, you know,
link |
01:45:36.800
the top philosophers about this,
link |
01:45:38.320
people like Daniel Dennett and David Chalmers and others
link |
01:45:41.160
who've obviously thought deeply about consciousness.
link |
01:45:43.680
Of course, consciousness itself hasn't been well,
link |
01:45:46.040
there's no agreed definition.
link |
01:45:47.760
If I was to, you know, speculate about that, you know,
link |
01:45:52.160
I kind of, the working definition I like is
link |
01:45:55.120
it's the way information feels when it gets processed.
link |
01:45:58.080
I think maybe Max Tegmark came up with that.
link |
01:46:00.160
I like that idea.
link |
01:46:01.040
I don't know if it helps us get towards
link |
01:46:02.280
any more operational thing,
link |
01:46:03.920
but I think it's a nice way of viewing it.
link |
01:46:07.800
I think we can obviously see from neuroscience
link |
01:46:10.000
certain prerequisites that are required,
link |
01:46:11.720
like self awareness, I think is necessary,
link |
01:46:14.440
but not sufficient component.
link |
01:46:16.080
This idea of a self and other
link |
01:46:18.160
and set of coherent preferences
link |
01:46:20.520
that are coherent over time.
link |
01:46:22.480
You know, these things are maybe memory.
link |
01:46:24.800
These things are probably needed
link |
01:46:26.200
for a sentient or conscious being.
link |
01:46:29.320
But the reason, the difficult thing,
link |
01:46:31.160
I think for us when we get,
link |
01:46:32.240
and I think this is a really interesting
link |
01:46:33.400
philosophical debate is when we get closer to AGI
link |
01:46:37.280
and, you know, and much more powerful systems
link |
01:46:40.680
than we have today,
link |
01:46:42.240
how are we going to make this judgment?
link |
01:46:44.440
And one way, which is the Turing test
link |
01:46:46.960
is sort of a behavioral judgment,
link |
01:46:48.640
is the system exhibiting all the behaviors
link |
01:46:52.080
that a human sentient or a sentient being would exhibit?
link |
01:46:56.880
Is it answering the right questions?
link |
01:46:58.160
Is it saying the right things?
link |
01:46:59.160
Is it indistinguishable from a human?
link |
01:47:01.960
And so on.
link |
01:47:03.360
But I think there's a second thing
link |
01:47:05.760
that makes us as humans regard each other as sentient,
link |
01:47:09.040
right?
link |
01:47:09.880
Why do we think this?
link |
01:47:10.920
And I debated this with Daniel Dennett.
link |
01:47:12.720
And I think there's a second reason
link |
01:47:13.880
that's often overlooked,
link |
01:47:15.600
which is that we're running on the same substrate, right?
link |
01:47:18.280
So if we're exhibiting the same behavior,
link |
01:47:21.120
more or less as humans,
link |
01:47:22.680
and we're running on the same, you know,
link |
01:47:24.400
carbon based biological substrate,
link |
01:47:26.200
the squishy, you know, few pounds of flesh in our skulls,
link |
01:47:29.560
then the most parsimonious, I think, explanation
link |
01:47:32.800
is that you're feeling the same thing as I'm feeling, right?
link |
01:47:35.520
But we will never have that second part,
link |
01:47:37.840
the substrate equivalence with a machine, right?
link |
01:47:41.200
So we will have to only judge based on the behavior.
link |
01:47:43.880
And I think the substrate equivalence
link |
01:47:45.920
is a critical part of why we make assumptions
link |
01:47:48.200
that we're conscious.
link |
01:47:49.080
And in fact, even with animals, high level animals,
link |
01:47:51.680
why we think they might be,
link |
01:47:52.680
because they're exhibiting some of the behaviors
link |
01:47:54.160
we would expect from a sentient animal.
link |
01:47:55.880
And we know they're made of the same things,
link |
01:47:57.600
biological neurons.
link |
01:47:58.640
So we're gonna have to come up with explanations
link |
01:48:02.880
or models of the gap between substrate differences,
link |
01:48:06.320
between machines and humans
link |
01:48:08.040
to get anywhere beyond the behavioral.
link |
01:48:10.840
But to me, sort of the practical question
link |
01:48:12.920
is very interesting and very important.
link |
01:48:16.040
When you have millions, perhaps billions of people
link |
01:48:18.640
believing that you have a sentient AI,
link |
01:48:20.800
believing what that Google engineer believed,
link |
01:48:24.040
which I just see as an obvious, very near term future thing,
link |
01:48:28.760
certainly on the path to AGI,
link |
01:48:31.160
how does that change the world?
link |
01:48:33.160
What's the responsibility of the AI system
link |
01:48:35.240
to help those millions of people?
link |
01:48:38.160
And also what's the ethical thing?
link |
01:48:39.760
Because you can make a lot of people happy
link |
01:48:44.760
by creating a meaningful, deep experience
link |
01:48:48.040
with a system that's faking it before it makes it.
link |
01:48:52.800
And I don't, are we the right,
link |
01:48:56.120
who is to say what's the right thing to do?
link |
01:48:59.720
Should AI always be tools?
link |
01:49:01.920
Why are we constraining AI to always be tools
link |
01:49:05.880
as opposed to friends?
link |
01:49:07.680
Yeah, I think, well, I mean, these are fantastic questions
link |
01:49:11.800
and also critical ones.
link |
01:49:13.840
And we've been thinking about this
link |
01:49:16.240
since the start of DeepMind and before that,
link |
01:49:18.080
because we plan for success
link |
01:49:19.560
and however remote that looked like back in 2010.
link |
01:49:24.640
And we've always had sort of these ethical considerations
link |
01:49:26.960
as fundamental at DeepMind.
link |
01:49:29.400
And my current thinking on the language models
link |
01:49:32.000
and large models is they're not ready,
link |
01:49:33.920
we don't understand them well enough yet.
link |
01:49:36.480
And in terms of analysis tools and guard rails,
link |
01:49:40.240
what they can and can't do and so on,
link |
01:49:42.080
to deploy them at scale, because I think,
link |
01:49:45.440
there are big, still ethical questions
link |
01:49:46.840
like should an AI system always announce
link |
01:49:48.640
that it is an AI system to begin with?
link |
01:49:50.600
Probably yes.
link |
01:49:52.800
What do you do about answering those philosophical questions
link |
01:49:55.520
about the feelings people may have about AI systems,
link |
01:49:58.800
perhaps incorrectly attributed?
link |
01:50:00.760
So I think there's a whole bunch of research
link |
01:50:02.840
that needs to be done first to responsibly,
link |
01:50:06.040
before you can responsibly deploy these systems at scale.
link |
01:50:09.120
That will be at least be my current position.
link |
01:50:12.080
Over time, I'm very confident we'll have those tools
link |
01:50:15.080
like interpretability questions and analysis questions.
link |
01:50:20.680
And then with the ethical quandary,
link |
01:50:23.200
I think there it's important to look beyond just science.
link |
01:50:28.520
That's why I think philosophy, social sciences,
link |
01:50:31.440
even theology, other things like that come into it,
link |
01:50:34.440
where arts and humanities,
link |
01:50:37.120
what does it mean to be human and the spirit of being human
link |
01:50:40.320
and to enhance that and the human condition, right?
link |
01:50:43.680
And allow us to experience things
link |
01:50:45.080
we could never experience before
link |
01:50:46.400
and improve the overall human condition
link |
01:50:49.080
and humanity overall, get radical abundance,
link |
01:50:51.640
solve many scientific problems, solve disease.
link |
01:50:54.120
So this is the era I think, this is the amazing era
link |
01:50:56.560
I think we're heading into if we do it right.
link |
01:50:59.480
But we've got to be careful.
link |
01:51:00.800
We've already seen with things like social media,
link |
01:51:02.680
how dual use technologies can be misused by,
link |
01:51:05.920
firstly, by bad actors or naive actors or crazy actors,
link |
01:51:12.040
right, so there's that set of just the common
link |
01:51:14.120
or garden misuse of existing dual use technology.
link |
01:51:18.000
And then of course, there's an additional thing
link |
01:51:20.960
that has to be overcome with AI
link |
01:51:21.960
that eventually it may have its own agency.
link |
01:51:24.480
So it could be good or bad in and of itself.
link |
01:51:28.720
So I think these questions have to be approached
link |
01:51:31.480
very carefully using the scientific method, I would say,
link |
01:51:35.360
in terms of hypothesis generation, careful control testing,
link |
01:51:38.680
not live A, B testing out in the world,
link |
01:51:40.680
because with powerful technologies like AI,
link |
01:51:44.400
if something goes wrong, it may cause a lot of harm
link |
01:51:47.640
before you can fix it.
link |
01:51:49.120
It's not like an imaging app or game app
link |
01:51:52.000
where if something goes wrong, it's relatively easy to fix
link |
01:51:56.160
and the harm is relatively small.
link |
01:51:57.960
So I think it comes with the usual cliche of,
link |
01:52:02.720
like with a lot of power comes a lot of responsibility.
link |
01:52:05.240
And I think that's the case here with things like AI,
link |
01:52:07.800
given the enormous opportunity in front of us.
link |
01:52:11.040
And I think we need a lot of voices
link |
01:52:14.040
and as many inputs into things like the design
link |
01:52:17.160
of the systems and the values they should have
link |
01:52:19.880
and what goals should they be put to.
link |
01:52:22.400
I think as wide a group of voices as possible
link |
01:52:24.560
beyond just the technologists is needed to input into that
link |
01:52:27.720
and to have a say in that,
link |
01:52:29.080
especially when it comes to deployment of these systems,
link |
01:52:31.840
which is when the rubber really hits the road,
link |
01:52:33.440
it really affects the general person in the street
link |
01:52:35.440
rather than fundamental research.
link |
01:52:37.400
And that's why I say, I think as a first step,
link |
01:52:40.240
it would be better if we have the choice
link |
01:52:42.360
to build these systems as tools to give,
link |
01:52:45.120
and I'm not saying that they should never go beyond tools
link |
01:52:47.960
because of course the potential is there
link |
01:52:50.360
for it to go way beyond just tools.
link |
01:52:52.960
But I think that would be a good first step
link |
01:52:55.800
in order for us to allow us to carefully experiment
link |
01:52:58.880
and understand what these things can do.
link |
01:53:01.000
So the leap between tool, the sentient entity being
link |
01:53:05.800
is one we should take very careful of.
link |
01:53:08.280
Let me ask a dark personal question.
link |
01:53:11.120
So you're one of the most brilliant people
link |
01:53:13.480
in the AI community, you're also one of the most kind
link |
01:53:16.800
and if I may say sort of loved people in the community.
link |
01:53:20.880
That said, creation of a super intelligent AI system
link |
01:53:25.880
would be one of the most powerful things in the world,
link |
01:53:32.720
tools or otherwise.
link |
01:53:34.840
And again, as the old saying goes, power corrupts
link |
01:53:38.400
and absolute power corrupts absolutely.
link |
01:53:41.640
You are likely to be one of the people,
link |
01:53:47.280
I would say probably the most likely person
link |
01:53:50.320
to be in the control of such a system.
link |
01:53:53.280
Do you think about the corrupting nature of power
link |
01:53:57.120
when you talk about these kinds of systems
link |
01:53:59.560
that as all dictators and people have caused atrocities
link |
01:54:04.920
in the past, always think they're doing good,
link |
01:54:07.760
but they don't do good because the power
link |
01:54:10.400
has polluted their mind about what is good
link |
01:54:12.560
and what is evil.
link |
01:54:13.720
Do you think about this stuff
link |
01:54:14.840
or are we just focused on language model?
link |
01:54:16.440
No, I think about them all the time
link |
01:54:18.760
and I think what are the defenses against that?
link |
01:54:22.360
I think one thing is to remain very grounded
link |
01:54:24.840
and sort of humble, no matter what you do or achieve.
link |
01:54:28.800
And I try to do that, my best friends
link |
01:54:31.160
are still my set of friends
link |
01:54:32.200
from my undergraduate Cambridge days,
link |
01:54:34.680
my family's and friends are very important.
link |
01:54:39.280
I've always, I think trying to be a multidisciplinary person,
link |
01:54:42.360
it helps to keep you humble
link |
01:54:43.760
because no matter how good you are at one topic,
link |
01:54:45.880
someone will be better than you at that.
link |
01:54:47.560
And always relearning a new topic again from scratch
link |
01:54:50.920
is a new field is very humbling, right?
link |
01:54:53.320
So for me, that's been biology over the last five years,
link |
01:54:56.400
huge area topic and I just love doing that,
link |
01:55:00.200
but it helps to keep you grounded
link |
01:55:01.600
like it keeps you open minded.
link |
01:55:04.320
And then the other important thing
link |
01:55:06.360
is to have a really good, amazing set of people around you
link |
01:55:10.040
at your company or your organization
link |
01:55:11.840
who are also very ethical and grounded themselves
link |
01:55:14.920
and help to keep you that way.
link |
01:55:16.840
And then ultimately just to answer your question,
link |
01:55:18.880
I hope we're gonna be a big part of birthing AI
link |
01:55:22.000
and that being the greatest benefit to humanity
link |
01:55:24.440
of any tool or technology ever,
link |
01:55:26.800
and getting us into a world of radical abundance
link |
01:55:29.560
and curing diseases and solving many of the big challenges
link |
01:55:33.960
we have in front of us.
link |
01:55:34.840
And then ultimately help the ultimate flourishing
link |
01:55:37.560
of humanity to travel the stars
link |
01:55:39.240
and find those aliens if they are there.
link |
01:55:41.160
And if they're not there, find out why they're not there,
link |
01:55:43.480
what is going on here in the universe.
link |
01:55:46.520
This is all to come.
link |
01:55:47.360
And that's what I've always dreamed about.
link |
01:55:50.720
But I think AI is too big an idea.
link |
01:55:53.000
It's not going to be,
link |
01:55:54.760
there'll be a certain set of pioneers who get there first.
link |
01:55:57.000
I hope we're in the vanguard
link |
01:55:58.600
so we can influence how that goes.
link |
01:56:00.400
And I think it matters who builds,
link |
01:56:02.480
which cultures they come from and what values they have,
link |
01:56:06.480
the builders of AI systems.
link |
01:56:07.840
Cause I think even though the AI system
link |
01:56:09.280
is gonna learn for itself most of its knowledge,
link |
01:56:11.560
there'll be a residue in the system of the culture
link |
01:56:14.760
and the values of the creators of that system.
link |
01:56:17.680
And there's interesting questions
link |
01:56:18.720
to discuss about that geopolitically.
link |
01:56:21.600
Different cultures,
link |
01:56:22.440
we're in a more fragmented world than ever, unfortunately.
link |
01:56:24.920
I think in terms of global cooperation,
link |
01:56:27.480
we see that in things like climate
link |
01:56:29.240
where we can't seem to get our act together globally
link |
01:56:32.000
to cooperate on these pressing matters.
link |
01:56:34.080
I hope that will change over time.
link |
01:56:35.600
Perhaps if we get to an era of radical abundance,
link |
01:56:38.640
we don't have to be so competitive anymore.
link |
01:56:40.440
Maybe we can be more cooperative
link |
01:56:42.680
if resources aren't so scarce.
link |
01:56:44.360
It's true that in terms of power corrupting
link |
01:56:48.240
and leading to destructive things,
link |
01:56:50.040
it seems that some of the atrocities of the past happen
link |
01:56:53.160
when there's a significant constraint on resources.
link |
01:56:56.680
I think that's the first thing.
link |
01:56:57.560
I don't think that's enough.
link |
01:56:58.400
I think scarcity is one thing that's led to competition,
link |
01:57:01.560
sort of zero sum game thinking.
link |
01:57:03.960
I would like us to all be in a positive sum world.
link |
01:57:06.080
And I think for that, you have to remove scarcity.
link |
01:57:08.480
I don't think that's enough, unfortunately,
link |
01:57:09.840
to get world peace
link |
01:57:10.800
because there's also other corrupting things
link |
01:57:12.800
like wanting power over people and this kind of stuff,
link |
01:57:15.520
which is not necessarily satisfied by just abundance.
link |
01:57:19.040
But I think it will help.
link |
01:57:22.400
But I think ultimately, AI is not gonna be run
link |
01:57:24.920
by any one person or one organization.
link |
01:57:26.800
I think it should belong to the world, belong to humanity.
link |
01:57:29.600
And I think there'll be many ways this will happen.
link |
01:57:33.120
And ultimately, everybody should have a say in that.
link |
01:57:36.840
Do you have advice for young people in high school,
link |
01:57:42.000
in college, maybe if they're interested in AI
link |
01:57:45.800
or interested in having a big impact on the world,
link |
01:57:50.640
what they should do to have a career they can be proud of
link |
01:57:53.200
or to have a life they can be proud of?
link |
01:57:55.000
I love giving talks to the next generation.
link |
01:57:57.400
What I say to them is actually two things.
link |
01:57:59.120
I think the most important things to learn about
link |
01:58:02.160
and to find out about when you're young
link |
01:58:04.520
is what are your true passions is first of all,
link |
01:58:07.080
as two things.
link |
01:58:07.920
One is find your true passions.
link |
01:58:09.720
And I think you can do that by,
link |
01:58:11.720
the way to do that is to explore as many things as possible
link |
01:58:14.600
when you're young and you have the time
link |
01:58:16.520
and you can take those risks.
link |
01:58:19.160
I would also encourage people to look at
link |
01:58:21.080
finding the connections between things in a unique way.
link |
01:58:24.600
I think that's a really great way to find a passion.
link |
01:58:27.280
Second thing I would say, advise is know yourself.
link |
01:58:30.600
So spend a lot of time understanding
link |
01:58:33.920
how you work best.
link |
01:58:35.600
Like what are the optimal times to work?
link |
01:58:37.680
What are the optimal ways that you study?
link |
01:58:39.880
What are your, how do you deal with pressure?
link |
01:58:42.240
Sort of test yourself in various scenarios
link |
01:58:44.560
and try and improve your weaknesses,
link |
01:58:47.240
but also find out what your unique skills and strengths are
link |
01:58:50.720
and then hone those.
link |
01:58:52.160
So then that's what will be your super value
link |
01:58:54.520
in the world later on.
link |
01:58:55.880
And if you can then combine those two things
link |
01:58:57.840
and find passions that you're genuinely excited about
link |
01:59:01.200
that intersect with what your unique strong skills are,
link |
01:59:05.360
then you're onto something incredible
link |
01:59:07.880
and I think you can make a huge difference in the world.
link |
01:59:10.920
So let me ask about know yourself.
link |
01:59:12.760
This is fun.
link |
01:59:13.600
This is fun.
link |
01:59:14.440
Quick questions about day in the life, the perfect day,
link |
01:59:18.120
the perfect productive day in the life of Demis's Hub.
link |
01:59:21.200
Maybe these days you're, there's a lot involved.
link |
01:59:26.200
So maybe a slightly younger Demis's Hub
link |
01:59:29.000
where you could focus on a single project maybe.
link |
01:59:33.120
How early do you wake up?
link |
01:59:34.440
Are you a night owl?
link |
01:59:35.600
Do you wake up early in the morning?
link |
01:59:36.760
What are some interesting habits?
link |
01:59:39.160
How many dozens of cups of coffees do you drink a day?
link |
01:59:42.400
What's the computer that you use?
link |
01:59:46.320
What's the setup?
link |
01:59:47.160
How many screens?
link |
01:59:47.980
What kind of keyboard?
link |
01:59:49.120
Are we talking Emacs Vim
link |
01:59:51.400
or are we talking something more modern?
link |
01:59:53.320
So there's a bunch of those questions.
link |
01:59:54.480
So maybe day in the life, what's the perfect day involved?
link |
01:59:58.960
Well, these days it's quite different
link |
02:00:00.880
from say 10, 20 years ago.
link |
02:00:02.680
Back 10, 20 years ago, it would have been
link |
02:00:05.480
a whole day of research, individual research or programming,
link |
02:00:10.900
doing some experiment, neuroscience,
link |
02:00:12.580
computer science experiment,
link |
02:00:14.080
reading lots of research papers.
link |
02:00:16.640
And then perhaps at nighttime,
link |
02:00:19.720
reading science fiction books or playing some games.
link |
02:00:25.440
But lots of focus, so like deep focused work
link |
02:00:28.360
on whether it's programming or reading research papers.
link |
02:00:32.440
Yes, so that would be lots of deep focus work.
link |
02:00:35.300
These days for the last sort of, I guess, five to 10 years,
link |
02:00:39.560
I've actually got quite a structure
link |
02:00:41.020
that works very well for me now,
link |
02:00:42.360
which is that I'm a complete night owl, always have been.
link |
02:00:46.140
So I optimize for that.
link |
02:00:47.680
So I'll basically do a normal day's work,
link |
02:00:50.760
get into work about 11 o clock
link |
02:00:52.560
and sort of do work to about seven in the office.
link |
02:00:56.400
And I will arrange back to back meetings
link |
02:00:58.960
for the entire time of that.
link |
02:01:00.920
And with as many, meet as many people as possible.
link |
02:01:03.200
So that's my collaboration management part of the day.
link |
02:01:06.500
Then I go home, spend time with the family and friends,
link |
02:01:10.680
have dinner, relax a little bit.
link |
02:01:13.600
And then I start a second day of work.
link |
02:01:15.240
I call it my second day of work around 10 p.m., 11 p.m.
link |
02:01:18.500
And that's the time to about the small hours of the morning,
link |
02:01:21.260
four or five in the morning, where I will do my thinking
link |
02:01:24.760
and reading and research, writing research papers.
link |
02:01:29.000
Sadly, I don't have time to code anymore,
link |
02:01:30.960
but it's not efficient to do that these days,
link |
02:01:34.900
given the amount of time I have.
link |
02:01:37.120
But that's when I do, you know,
link |
02:01:38.360
maybe do the long kind of stretches
link |
02:01:40.760
of thinking and planning.
link |
02:01:42.440
And then probably, you know, using email, other things,
link |
02:01:45.280
I would set, I would fire off a lot of things to my team
link |
02:01:47.880
to deal with the next morning.
link |
02:01:49.360
But actually thinking about this overnight,
link |
02:01:51.640
we should go for this project
link |
02:01:53.200
or arrange this meeting the next day.
link |
02:01:54.880
When you're thinking through a problem,
link |
02:01:56.120
are you talking about a sheet of paper with a pen?
link |
02:01:58.160
Is there some structured process?
link |
02:02:01.040
I still like pencil and paper best for working out things,
link |
02:02:04.360
but these days it's just so efficient
link |
02:02:06.720
to read research papers just on the screen.
link |
02:02:08.720
I still often print them out, actually.
link |
02:02:10.220
I still prefer to mark out things.
link |
02:02:12.540
And I find it goes into the brain better
link |
02:02:14.880
and sticks in the brain better
link |
02:02:16.000
when you're still using physical pen and pencil and paper.
link |
02:02:19.440
So you take notes with the...
link |
02:02:20.800
I have lots of notes, electronic ones,
link |
02:02:22.440
and also whole stacks of notebooks that I use at home, yeah.
link |
02:02:27.640
On some of these most challenging next steps, for example,
link |
02:02:30.320
stuff none of us know about that you're working on,
link |
02:02:33.800
you're thinking,
link |
02:02:35.580
there's some deep thinking required there, right?
link |
02:02:37.640
Like what is the right problem?
link |
02:02:39.420
What is the right approach?
link |
02:02:41.280
Because you're gonna have to invest a huge amount of time
link |
02:02:43.920
for the whole team.
link |
02:02:44.800
They're going to have to pursue this thing.
link |
02:02:46.760
What's the right way to do it?
link |
02:02:48.560
Is RL gonna work here or not?
link |
02:02:50.040
Yes.
link |
02:02:50.880
What's the right thing to try?
link |
02:02:53.120
What's the right benchmark to use?
link |
02:02:55.120
Do we need to construct a benchmark from scratch?
link |
02:02:57.320
All those kinds of things.
link |
02:02:58.200
Yes.
link |
02:02:59.040
So I think of all those kinds of things
link |
02:03:00.200
in the nighttime phase, but also much more,
link |
02:03:03.480
I find I've always found the quiet hours of the morning
link |
02:03:07.660
when everyone's asleep, it's super quiet outside.
link |
02:03:11.420
I love that time.
link |
02:03:12.280
It's the golden hours,
link |
02:03:13.360
like between one and three in the morning.
link |
02:03:16.480
Put some music on, some inspiring music on,
link |
02:03:18.880
and then think these deep thoughts.
link |
02:03:21.600
So that's when I would read my philosophy books
link |
02:03:24.240
and Spinoza's, my recent favorite can, all these things.
link |
02:03:28.820
And I read about a great scientist of history,
link |
02:03:33.660
how they did things, how they thought things.
link |
02:03:35.640
So that's when you do all your creative,
link |
02:03:37.240
that's when I do all my creative thinking.
link |
02:03:39.160
And it's good, I think people recommend
link |
02:03:41.840
you do your sort of creative thinking in one block.
link |
02:03:45.120
And the way I organize the day,
link |
02:03:47.160
that way I don't get interrupted.
link |
02:03:48.560
There's obviously no one else is up at those times.
link |
02:03:51.460
So I can go, I can sort of get super deep
link |
02:03:55.880
and super into flow.
link |
02:03:57.560
The other nice thing about doing it nighttime wise
link |
02:03:59.640
is if I'm really onto something
link |
02:04:02.760
or I've got really deep into something,
link |
02:04:04.940
I can choose to extend it
link |
02:04:06.840
and I'll go into six in the morning, whatever.
link |
02:04:09.000
And then I'll just pay for it the next day.
link |
02:04:10.760
So I'll be a bit tired and I won't be my best,
link |
02:04:12.960
but that's fine.
link |
02:04:13.900
I can decide looking at my schedule the next day
link |
02:04:16.840
and given where I'm at with this particular thought
link |
02:04:19.360
or creative idea that I'm gonna pay that cost the next day.
link |
02:04:22.840
So I think that's more flexible than morning people
link |
02:04:26.220
who do that, they get up at four in the morning.
link |
02:04:28.780
They can also do those golden hours then,
link |
02:04:31.000
but then their start of their scheduled day
link |
02:04:32.640
starts at breakfast, 8 a.m.,
link |
02:04:34.440
whatever they have their first meeting.
link |
02:04:36.040
And then it's hard, you have to reschedule a day
link |
02:04:37.880
if you're in flow.
link |
02:04:38.960
So I don't have to do that.
link |
02:04:39.800
So that could be a true special thread of thoughts
link |
02:04:41.880
that you're too passionate about.
link |
02:04:45.160
This is where some of the greatest ideas
link |
02:04:46.740
could potentially come is when you just lose yourself
link |
02:04:49.320
late into the night.
link |
02:04:51.360
And for the meetings, I mean, you're loading in
link |
02:04:53.860
really hard problems in a very short amount of time.
link |
02:04:56.520
So you have to do some kind of first principles thinking
link |
02:04:58.800
here, it's like, what's the problem?
link |
02:05:00.160
What's the state of things?
link |
02:05:01.360
What's the right next steps?
link |
02:05:03.120
You have to get really good at context switching,
link |
02:05:05.120
which is one of the hardest things,
link |
02:05:07.200
because especially as we do so many things,
link |
02:05:09.020
if you include all the scientific things we do,
link |
02:05:10.800
scientific fields we're working in,
link |
02:05:12.600
these are complex fields in themselves.
link |
02:05:15.380
And you have to sort of keep abreast of that.
link |
02:05:18.960
But I enjoy it.
link |
02:05:20.000
I've always been a sort of generalist in a way.
link |
02:05:23.840
And that's actually what happened in my games career
link |
02:05:25.600
after chess.
link |
02:05:27.880
One of the reasons I stopped playing chess
link |
02:05:29.260
was because I got into computers,
link |
02:05:30.320
but also I started realizing there were many other
link |
02:05:32.280
great games out there to play too.
link |
02:05:33.880
So I've always been that way inclined, multidisciplinary.
link |
02:05:36.920
And there's too many interesting things in the world
link |
02:05:39.120
to spend all your time just on one thing.
link |
02:05:41.680
So you mentioned Spinoza, gotta ask the big, ridiculously
link |
02:05:45.640
big question about life.
link |
02:05:47.640
What do you think is the meaning of this whole thing?
link |
02:05:50.480
Why are we humans here?
link |
02:05:52.560
You've already mentioned that perhaps the universe
link |
02:05:55.120
created us.
link |
02:05:56.720
Is that why you think we're here?
link |
02:05:58.920
To understand how the universe works?
link |
02:06:00.120
Yeah, I think my answer to that would be,
link |
02:06:02.080
and at least the life I'm living,
link |
02:06:03.960
is to gain and understand the knowledge,
link |
02:06:08.120
to gain knowledge and understand the universe.
link |
02:06:10.600
That's what I think, I can't see any higher purpose
link |
02:06:13.560
than that if you think back to the classical Greeks,
link |
02:06:15.720
the virtue of gaining knowledge.
link |
02:06:17.560
It's, I think it's one of the few true virtues
link |
02:06:20.440
is to understand the world around us
link |
02:06:23.600
and the context and humanity better.
link |
02:06:25.680
And I think if you do that, you become more compassionate
link |
02:06:29.140
and more understanding yourself and more tolerant
link |
02:06:32.080
and all these, I think all these other things
link |
02:06:33.580
may flow from that.
link |
02:06:34.760
And to me, understanding the nature of reality,
link |
02:06:37.640
that is the biggest question.
link |
02:06:38.760
What is going on here is sometimes the colloquial way I say.
link |
02:06:41.400
What is really going on here?
link |
02:06:43.600
It's so mysterious.
link |
02:06:44.900
I feel like we're in some huge puzzle.
link |
02:06:47.040
And it's, but the world is also seems to be,
link |
02:06:49.960
the universe seems to be structured in a way.
link |
02:06:52.880
You know, why is it structured in a way
link |
02:06:54.280
that science is even possible?
link |
02:06:55.840
That, you know, methods, the scientific method works,
link |
02:06:58.160
things are repeatable.
link |
02:07:00.240
It feels like it's almost structured in a way
link |
02:07:02.560
to be conducive to gaining knowledge.
link |
02:07:05.000
So I feel like, and you know,
link |
02:07:06.480
why should computers be even possible?
link |
02:07:07.960
Wasn't that amazing that computational electronic devices
link |
02:07:11.880
can be possible, and they're made of sand,
link |
02:07:15.300
our most common element that we have,
link |
02:07:17.280
you know, silicon on the Earth's crust.
link |
02:07:19.960
It could have been made of diamond or something,
link |
02:07:21.480
then we would have only had one computer.
link |
02:07:23.800
So a lot of things are kind of slightly suspicious to me.
link |
02:07:26.560
It sure as heck sounds, this puzzle sure as heck sounds
link |
02:07:29.220
like something we talked about earlier,
link |
02:07:30.760
what it takes to design a game that's really fun to play
link |
02:07:35.120
for prolonged periods of time.
link |
02:07:36.620
And it does seem like this puzzle, like you mentioned,
link |
02:07:40.420
the more you learn about it,
link |
02:07:42.280
the more you realize how little you know.
link |
02:07:44.860
So it humbles you, but excites you
link |
02:07:46.820
by the possibility of learning more.
link |
02:07:49.020
It's one heck of a puzzle we got going on here.
link |
02:07:53.560
So like I mentioned, of all the people in the world,
link |
02:07:56.420
you're very likely to be the one who creates the AGI system
link |
02:08:02.580
that achieves human level intelligence and goes beyond it.
link |
02:08:06.320
So if you got a chance and very well,
link |
02:08:08.360
you could be the person that goes into the room
link |
02:08:10.340
with the system and have a conversation.
link |
02:08:13.140
Maybe you only get to ask one question.
link |
02:08:15.260
If you do, what question would you ask her?
link |
02:08:19.460
I would probably ask, what is the true nature of reality?
link |
02:08:23.660
I think that's the question.
link |
02:08:24.560
I don't know if I'd understand the answer
link |
02:08:25.980
because maybe it would be 42 or something like that,
link |
02:08:28.540
but that's the question I would ask.
link |
02:08:32.420
And then there'll be a deep sigh from the systems,
link |
02:08:34.820
like, all right, how do I explain to this human?
link |
02:08:37.460
All right, let me, I don't have time to explain.
link |
02:08:41.860
Maybe I'll draw you a picture that it is.
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02:08:44.660
I mean, how do you even begin to answer that question?
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02:08:51.280
Well, I think it would.
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02:08:52.780
What would you think the answer could possibly look like?
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02:08:55.680
I think it could start looking like
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02:08:59.940
more fundamental explanations of physics
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02:09:02.060
would be the beginning.
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02:09:03.900
More careful specification of that,
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02:09:05.740
taking you, walking us through by the hand
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02:09:07.700
as to what one would do to maybe prove those things out.
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02:09:10.620
Maybe giving you glimpses of what things
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02:09:13.700
you totally miss in the physics of today.
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02:09:15.740
Exactly, exactly.
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02:09:16.700
Just here's glimpses of, no, like there's a much,
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02:09:22.260
a much more elaborate world
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02:09:23.640
or a much simpler world or something.
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02:09:26.780
A much deeper, maybe simpler explanation of things,
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02:09:30.260
right, than the standard model of physics,
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02:09:31.900
which we know doesn't work, but we still keep adding to.
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02:09:34.860
So, and that's how I think the beginning
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02:09:37.940
of an explanation would look.
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02:09:38.940
And it would start encompassing many of the mysteries
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02:09:41.260
that we have wondered about for thousands of years,
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02:09:43.380
like consciousness, dreaming, life, and gravity,
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02:09:47.900
all of these things.
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02:09:48.820
Yeah, giving us glimpses of explanations for those things.
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02:09:52.620
Well, Damasir, one of the special human beings
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02:09:57.180
in this giant puzzle of ours,
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02:09:59.080
and it's a huge honor that you would take a pause
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02:10:01.020
from the bigger puzzle to solve this small puzzle
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02:10:03.260
of a conversation with me today.
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02:10:04.780
It's truly an honor and a pleasure.
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02:10:06.300
Thank you so much.
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02:10:07.140
Thank you, I really enjoyed it.
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02:10:07.960
Thanks, Lex.
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02:10:09.100
Thanks for listening to this conversation
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02:10:10.580
with Damas Ashabis.
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02:10:11.980
To support this podcast,
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02:10:13.180
please check out our sponsors in the description.
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02:10:15.820
And now, let me leave you with some words
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02:10:17.900
from Edgar Dykstra.
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02:10:20.380
Computer science is no more about computers
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02:10:23.500
than astronomy is about telescopes.
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02:10:26.260
Thank you for listening, and hope to see you next time.